Stabilizing the closed SARS-CoV-2 spike trimer

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Stabilizing the closed SARS-CoV-2 spike trimer

SARS-CoV-2 S protein prematurely refolds to the post-fusion conformation, compromising immunogenic properties and prefusion trimer yield. Here, Juraszek et al. present a stable SARS-CoV-2 S-closed protein variant with increased expression and correct folding, predominantly in closed prefusion confor...

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Détails bibliographiques
Auteurs principaux:	Jarek Juraszek, Lucy Rutten, Sven Blokland, Pascale Bouchier, Richard Voorzaat, Tina Ritschel, Mark J. G. Bakkers, Ludovic L. R. Renault, Johannes P. M. Langedijk
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/fef6c96d1aae41d7a61ebeb8f94b38a6
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

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