Factors affecting resolution of subretinal fluid after selective retina therapy for central serous chorioretinopathy

Abstract The purpose of this study was to investigate the factors of clinical outcome of selective retina therapy (SRT) for central serous chorioretinopathy (CSC). This retrospective study included 77 eyes of 77 patients, who were treated with SRT for CSC and observed at least 6 months after the tre...

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Autores principales:	Akika Kyo, Manabu Yamamoto, Kumiko Hirayama, Takeya Kohno, Dirk Theisen-Kunde, Ralf Brinkmann, Yoko Miura, Shigeru Honda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fef701fd04bc46548b9cbe3414e5a110
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spelling	oai:doaj.org-article:fef701fd04bc46548b9cbe3414e5a1102021-12-02T17:39:23ZFactors affecting resolution of subretinal fluid after selective retina therapy for central serous chorioretinopathy10.1038/s41598-021-88372-82045-2322https://doaj.org/article/fef701fd04bc46548b9cbe3414e5a1102021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88372-8https://doaj.org/toc/2045-2322Abstract The purpose of this study was to investigate the factors of clinical outcome of selective retina therapy (SRT) for central serous chorioretinopathy (CSC). This retrospective study included 77 eyes of 77 patients, who were treated with SRT for CSC and observed at least 6 months after the treatment. SRT laser (527 nm, 1.7 µs, 100 Hz) was used for treatment. The mean best-corrected visual acuity (logMAR), central macular thickness (CMT) and central choroidal thickness were changed from baseline to at 6-months follow-up with significant difference. The multivariate analyses found that the rate of change (reduction) in CMT was associated with focal leakage type on fluorescein angiography (FA) (p = 0.03, coefficient 15.26, 95% confidence interval 1.72–28.79) and larger baseline CMT (p < 0.01, coefficient − 0.13, 95% confidence interval − 0.13 to − 0.05). Complete resolution of subretinal fluid was associated with nonsmoking history (p = 0.03, odds ratio 0.276, 95% confidence interval 0.086–0.887) and focal leakage type on FA (p < 0.01, odds ratio 0.136, 95% confidence interval 0.042–0.437). These results may be useful for predicting the therapeutic effectiveness of SRT.Akika KyoManabu YamamotoKumiko HirayamaTakeya KohnoDirk Theisen-KundeRalf BrinkmannYoko MiuraShigeru HondaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Akika Kyo Manabu Yamamoto Kumiko Hirayama Takeya Kohno Dirk Theisen-Kunde Ralf Brinkmann Yoko Miura Shigeru Honda Factors affecting resolution of subretinal fluid after selective retina therapy for central serous chorioretinopathy
description	Abstract The purpose of this study was to investigate the factors of clinical outcome of selective retina therapy (SRT) for central serous chorioretinopathy (CSC). This retrospective study included 77 eyes of 77 patients, who were treated with SRT for CSC and observed at least 6 months after the treatment. SRT laser (527 nm, 1.7 µs, 100 Hz) was used for treatment. The mean best-corrected visual acuity (logMAR), central macular thickness (CMT) and central choroidal thickness were changed from baseline to at 6-months follow-up with significant difference. The multivariate analyses found that the rate of change (reduction) in CMT was associated with focal leakage type on fluorescein angiography (FA) (p = 0.03, coefficient 15.26, 95% confidence interval 1.72–28.79) and larger baseline CMT (p < 0.01, coefficient − 0.13, 95% confidence interval − 0.13 to − 0.05). Complete resolution of subretinal fluid was associated with nonsmoking history (p = 0.03, odds ratio 0.276, 95% confidence interval 0.086–0.887) and focal leakage type on FA (p < 0.01, odds ratio 0.136, 95% confidence interval 0.042–0.437). These results may be useful for predicting the therapeutic effectiveness of SRT.
format	article
author	Akika Kyo Manabu Yamamoto Kumiko Hirayama Takeya Kohno Dirk Theisen-Kunde Ralf Brinkmann Yoko Miura Shigeru Honda
author_facet	Akika Kyo Manabu Yamamoto Kumiko Hirayama Takeya Kohno Dirk Theisen-Kunde Ralf Brinkmann Yoko Miura Shigeru Honda
author_sort	Akika Kyo
title	Factors affecting resolution of subretinal fluid after selective retina therapy for central serous chorioretinopathy
title_short	Factors affecting resolution of subretinal fluid after selective retina therapy for central serous chorioretinopathy
title_full	Factors affecting resolution of subretinal fluid after selective retina therapy for central serous chorioretinopathy
title_fullStr	Factors affecting resolution of subretinal fluid after selective retina therapy for central serous chorioretinopathy
title_full_unstemmed	Factors affecting resolution of subretinal fluid after selective retina therapy for central serous chorioretinopathy
title_sort	factors affecting resolution of subretinal fluid after selective retina therapy for central serous chorioretinopathy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fef701fd04bc46548b9cbe3414e5a110
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Factors affecting resolution of subretinal fluid after selective retina therapy for central serous chorioretinopathy

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