Significance of baseline and change in neutrophil-to-lymphocyte ratio in predicting prognosis: a retrospective analysis in advanced pancreatic ductal adenocarcinoma

Abstract The neutrophil-lymphocyte ratio (NLR) has been reported to be associated with prognosis in several cancers. The objective of our study was to evaluate the prognostic role of baseline NLR and change in NLR (ΔNLR) in advanced pancreatic cancer underwent chemotherapy. Between January 2010 and...

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Autores principales:	Yang Chen, Huan Yan, YanRong Wang, Yan Shi, GuangHai Dai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fef74e5cbe314d4fa8dd3bfc0f7f4e9b
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spelling	oai:doaj.org-article:fef74e5cbe314d4fa8dd3bfc0f7f4e9b2021-12-02T12:32:43ZSignificance of baseline and change in neutrophil-to-lymphocyte ratio in predicting prognosis: a retrospective analysis in advanced pancreatic ductal adenocarcinoma10.1038/s41598-017-00859-52045-2322https://doaj.org/article/fef74e5cbe314d4fa8dd3bfc0f7f4e9b2017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00859-5https://doaj.org/toc/2045-2322Abstract The neutrophil-lymphocyte ratio (NLR) has been reported to be associated with prognosis in several cancers. The objective of our study was to evaluate the prognostic role of baseline NLR and change in NLR (ΔNLR) in advanced pancreatic cancer underwent chemotherapy. Between January 2010 and June 2015, 132 patients underwent chemotherapy were eligible for assessment. Based on our patients’ data, the cut-off value of NLR was 2.78 according to receiver operating characteristic curve. We observed that a high level of baseline NLR (NLR > 2.78) was a poor prognostic factor for overall survival (multivariable hazard ratio [HR] = 2.648, P < 0.001). Increased NLR (ΔNLR > 0) after 2 cycles of chemotherapy was associated with higher risk compared to ΔNLR ≤ 0 (multivariable HR = 1.894, P = 0.007). Combining both NLR and ΔNLR factors, multivariate analysis showed a significant higher risk (HR = 5.817, P < 0.001) for patients with high baseline NLR and increased NLR after 2 cycles of chemotherapy compared to patients with low baseline NLR and ΔNLR ≤ 0. In conclusion, both baseline NLR and ΔNLR are independent prognostic predictors for patients with advanced pancreatic cancer underwent chemotherapy.Yang ChenHuan YanYanRong WangYan ShiGuangHai DaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yang Chen Huan Yan YanRong Wang Yan Shi GuangHai Dai Significance of baseline and change in neutrophil-to-lymphocyte ratio in predicting prognosis: a retrospective analysis in advanced pancreatic ductal adenocarcinoma
description	Abstract The neutrophil-lymphocyte ratio (NLR) has been reported to be associated with prognosis in several cancers. The objective of our study was to evaluate the prognostic role of baseline NLR and change in NLR (ΔNLR) in advanced pancreatic cancer underwent chemotherapy. Between January 2010 and June 2015, 132 patients underwent chemotherapy were eligible for assessment. Based on our patients’ data, the cut-off value of NLR was 2.78 according to receiver operating characteristic curve. We observed that a high level of baseline NLR (NLR > 2.78) was a poor prognostic factor for overall survival (multivariable hazard ratio [HR] = 2.648, P < 0.001). Increased NLR (ΔNLR > 0) after 2 cycles of chemotherapy was associated with higher risk compared to ΔNLR ≤ 0 (multivariable HR = 1.894, P = 0.007). Combining both NLR and ΔNLR factors, multivariate analysis showed a significant higher risk (HR = 5.817, P < 0.001) for patients with high baseline NLR and increased NLR after 2 cycles of chemotherapy compared to patients with low baseline NLR and ΔNLR ≤ 0. In conclusion, both baseline NLR and ΔNLR are independent prognostic predictors for patients with advanced pancreatic cancer underwent chemotherapy.
format	article
author	Yang Chen Huan Yan YanRong Wang Yan Shi GuangHai Dai
author_facet	Yang Chen Huan Yan YanRong Wang Yan Shi GuangHai Dai
author_sort	Yang Chen
title	Significance of baseline and change in neutrophil-to-lymphocyte ratio in predicting prognosis: a retrospective analysis in advanced pancreatic ductal adenocarcinoma
title_short	Significance of baseline and change in neutrophil-to-lymphocyte ratio in predicting prognosis: a retrospective analysis in advanced pancreatic ductal adenocarcinoma
title_full	Significance of baseline and change in neutrophil-to-lymphocyte ratio in predicting prognosis: a retrospective analysis in advanced pancreatic ductal adenocarcinoma
title_fullStr	Significance of baseline and change in neutrophil-to-lymphocyte ratio in predicting prognosis: a retrospective analysis in advanced pancreatic ductal adenocarcinoma
title_full_unstemmed	Significance of baseline and change in neutrophil-to-lymphocyte ratio in predicting prognosis: a retrospective analysis in advanced pancreatic ductal adenocarcinoma
title_sort	significance of baseline and change in neutrophil-to-lymphocyte ratio in predicting prognosis: a retrospective analysis in advanced pancreatic ductal adenocarcinoma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/fef74e5cbe314d4fa8dd3bfc0f7f4e9b
work_keys_str_mv	AT yangchen significanceofbaselineandchangeinneutrophiltolymphocyteratioinpredictingprognosisaretrospectiveanalysisinadvancedpancreaticductaladenocarcinoma AT huanyan significanceofbaselineandchangeinneutrophiltolymphocyteratioinpredictingprognosisaretrospectiveanalysisinadvancedpancreaticductaladenocarcinoma AT yanrongwang significanceofbaselineandchangeinneutrophiltolymphocyteratioinpredictingprognosisaretrospectiveanalysisinadvancedpancreaticductaladenocarcinoma AT yanshi significanceofbaselineandchangeinneutrophiltolymphocyteratioinpredictingprognosisaretrospectiveanalysisinadvancedpancreaticductaladenocarcinoma AT guanghaidai significanceofbaselineandchangeinneutrophiltolymphocyteratioinpredictingprognosisaretrospectiveanalysisinadvancedpancreaticductaladenocarcinoma
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Significance of baseline and change in neutrophil-to-lymphocyte ratio in predicting prognosis: a retrospective analysis in advanced pancreatic ductal adenocarcinoma

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