The cyclooxygenase-1/mPGES-1/endothelial prostaglandin EP4 receptor pathway constrains myocardial ischemia-reperfusion injury

The cyclooxygenase-1/mPGES-1/endothelial prostaglandin EP4 receptor pathway constrains myocardial ischemia-reperfusion injury

The use of nonsteroidal anti-inflammatory drugs inhibiting COX-1/2 is associated with an increased risk of heart failure. Here the authors show that mPGES-1, a therapeutic target downstream of COX enzymes, protects from cardiac ischemia/reperfusion injury, limiting leukocyte-endothelial interactions...

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Autores principales: Liyuan Zhu, Chuansheng Xu, Xingyu Huo, Huifeng Hao, Qing Wan, Hong Chen, Xu Zhang, Richard M. Breyer, Yu Huang, Xuetao Cao, De-Pei Liu, Garret A. FitzGerald, Miao Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/fef88a14e9b647e0a6efff38e6e014ef
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spelling oai:doaj.org-article:fef88a14e9b647e0a6efff38e6e014ef2021-12-02T15:35:10ZThe cyclooxygenase-1/mPGES-1/endothelial prostaglandin EP4 receptor pathway constrains myocardial ischemia-reperfusion injury10.1038/s41467-019-09492-42041-1723https://doaj.org/article/fef88a14e9b647e0a6efff38e6e014ef2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09492-4https://doaj.org/toc/2041-1723The use of nonsteroidal anti-inflammatory drugs inhibiting COX-1/2 is associated with an increased risk of heart failure. Here the authors show that mPGES-1, a therapeutic target downstream of COX enzymes, protects from cardiac ischemia/reperfusion injury, limiting leukocyte-endothelial interactions and preserving microvascular perfusion partly via the endothelial EP4 receptor.Liyuan ZhuChuansheng XuXingyu HuoHuifeng HaoQing WanHong ChenXu ZhangRichard M. BreyerYu HuangXuetao CaoDe-Pei LiuGarret A. FitzGeraldMiao WangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Liyuan Zhu
Chuansheng Xu
Xingyu Huo
Huifeng Hao
Qing Wan
Hong Chen
Xu Zhang
Richard M. Breyer
Yu Huang
Xuetao Cao
De-Pei Liu
Garret A. FitzGerald
Miao Wang
The cyclooxygenase-1/mPGES-1/endothelial prostaglandin EP4 receptor pathway constrains myocardial ischemia-reperfusion injury
description The use of nonsteroidal anti-inflammatory drugs inhibiting COX-1/2 is associated with an increased risk of heart failure. Here the authors show that mPGES-1, a therapeutic target downstream of COX enzymes, protects from cardiac ischemia/reperfusion injury, limiting leukocyte-endothelial interactions and preserving microvascular perfusion partly via the endothelial EP4 receptor.
format article
author Liyuan Zhu
Chuansheng Xu
Xingyu Huo
Huifeng Hao
Qing Wan
Hong Chen
Xu Zhang
Richard M. Breyer
Yu Huang
Xuetao Cao
De-Pei Liu
Garret A. FitzGerald
Miao Wang
author_facet Liyuan Zhu
Chuansheng Xu
Xingyu Huo
Huifeng Hao
Qing Wan
Hong Chen
Xu Zhang
Richard M. Breyer
Yu Huang
Xuetao Cao
De-Pei Liu
Garret A. FitzGerald
Miao Wang
author_sort Liyuan Zhu
title The cyclooxygenase-1/mPGES-1/endothelial prostaglandin EP4 receptor pathway constrains myocardial ischemia-reperfusion injury
title_short The cyclooxygenase-1/mPGES-1/endothelial prostaglandin EP4 receptor pathway constrains myocardial ischemia-reperfusion injury
title_full The cyclooxygenase-1/mPGES-1/endothelial prostaglandin EP4 receptor pathway constrains myocardial ischemia-reperfusion injury
title_fullStr The cyclooxygenase-1/mPGES-1/endothelial prostaglandin EP4 receptor pathway constrains myocardial ischemia-reperfusion injury
title_full_unstemmed The cyclooxygenase-1/mPGES-1/endothelial prostaglandin EP4 receptor pathway constrains myocardial ischemia-reperfusion injury
title_sort cyclooxygenase-1/mpges-1/endothelial prostaglandin ep4 receptor pathway constrains myocardial ischemia-reperfusion injury
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/fef88a14e9b647e0a6efff38e6e014ef
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