TIGAR is correlated with maximal standardized uptake value on FDG-PET and survival in non-small cell lung cancer.

<h4>Objective</h4>Evaluation of (18)F-FDG uptake value via PET is central to current methods of diagnosis and staging of non-small cell lung cancer (NSCLC) due to its ability to evaluate expression levels of key regulators associated with glucose metabolism in tumor cells. Tp53-induced g...

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Autores principales:	Xiang Zhou, Wenhui Xie, Qian Li, Yifan Zhang, Jie Zhang, Xiaoping Zhao, Jianjun Liu, Gang Huang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fefbbebbcf2549c29896420c5c829451
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spelling	oai:doaj.org-article:fefbbebbcf2549c29896420c5c8294512021-11-18T08:42:34ZTIGAR is correlated with maximal standardized uptake value on FDG-PET and survival in non-small cell lung cancer.1932-620310.1371/journal.pone.0080576https://doaj.org/article/fefbbebbcf2549c29896420c5c8294512013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24363807/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>Evaluation of (18)F-FDG uptake value via PET is central to current methods of diagnosis and staging of non-small cell lung cancer (NSCLC) due to its ability to evaluate expression levels of key regulators associated with glucose metabolism in tumor cells. Tp53-induced glycolysis and apoptosis regulator (TIGAR) is an important P53-induced protein that can inhibit glycolysis; however, there have been few clinical studies on its mechanism. Here we have investigated the relationship between TIGAR expression and (18)F-FDG PET in tumors, along with its relationship with the clinical characteristics of NSCLC.<h4>Methods</h4>We analyzed SUVmax in 79 patients with NSCLC through immunohistochemical staining of TIGAR and five other biological markers associated with tumor cell glycolysis, in order to evaluate the correlation between their expression and SUVmax. We also plotted Kaplan-Meier survival curves to assess TIGAR expression with the prognosis and survival of patients with NSCLC.<h4>Results</h4>The key findings were as follows: SUVmax was negatively correlated with the expression of TIGAR (r = -0.31, p<0.01); TIGAR expression was correlated with tumor size (p = 0.01), histological type (p<0.01), differentiation degree (p<0.01) and lymph node metastasis(p<0.01) in patients with NSCLC; and the survival time of patients whose TIGAR was negatively expressed was significantly shorter than for those whose TIGAR was positively expressed (P = 0.023).<h4>Conclusions</h4>The expression of TIGAR in primary tumors is significantly correlated with SUVmax, and low expression of TIGAR may predict a worse clinical outcome in patients with NSCLC.Xiang ZhouWenhui XieQian LiYifan ZhangJie ZhangXiaoping ZhaoJianjun LiuGang HuangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e80576 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiang Zhou Wenhui Xie Qian Li Yifan Zhang Jie Zhang Xiaoping Zhao Jianjun Liu Gang Huang TIGAR is correlated with maximal standardized uptake value on FDG-PET and survival in non-small cell lung cancer.
description	<h4>Objective</h4>Evaluation of (18)F-FDG uptake value via PET is central to current methods of diagnosis and staging of non-small cell lung cancer (NSCLC) due to its ability to evaluate expression levels of key regulators associated with glucose metabolism in tumor cells. Tp53-induced glycolysis and apoptosis regulator (TIGAR) is an important P53-induced protein that can inhibit glycolysis; however, there have been few clinical studies on its mechanism. Here we have investigated the relationship between TIGAR expression and (18)F-FDG PET in tumors, along with its relationship with the clinical characteristics of NSCLC.<h4>Methods</h4>We analyzed SUVmax in 79 patients with NSCLC through immunohistochemical staining of TIGAR and five other biological markers associated with tumor cell glycolysis, in order to evaluate the correlation between their expression and SUVmax. We also plotted Kaplan-Meier survival curves to assess TIGAR expression with the prognosis and survival of patients with NSCLC.<h4>Results</h4>The key findings were as follows: SUVmax was negatively correlated with the expression of TIGAR (r = -0.31, p<0.01); TIGAR expression was correlated with tumor size (p = 0.01), histological type (p<0.01), differentiation degree (p<0.01) and lymph node metastasis(p<0.01) in patients with NSCLC; and the survival time of patients whose TIGAR was negatively expressed was significantly shorter than for those whose TIGAR was positively expressed (P = 0.023).<h4>Conclusions</h4>The expression of TIGAR in primary tumors is significantly correlated with SUVmax, and low expression of TIGAR may predict a worse clinical outcome in patients with NSCLC.
format	article
author	Xiang Zhou Wenhui Xie Qian Li Yifan Zhang Jie Zhang Xiaoping Zhao Jianjun Liu Gang Huang
author_facet	Xiang Zhou Wenhui Xie Qian Li Yifan Zhang Jie Zhang Xiaoping Zhao Jianjun Liu Gang Huang
author_sort	Xiang Zhou
title	TIGAR is correlated with maximal standardized uptake value on FDG-PET and survival in non-small cell lung cancer.
title_short	TIGAR is correlated with maximal standardized uptake value on FDG-PET and survival in non-small cell lung cancer.
title_full	TIGAR is correlated with maximal standardized uptake value on FDG-PET and survival in non-small cell lung cancer.
title_fullStr	TIGAR is correlated with maximal standardized uptake value on FDG-PET and survival in non-small cell lung cancer.
title_full_unstemmed	TIGAR is correlated with maximal standardized uptake value on FDG-PET and survival in non-small cell lung cancer.
title_sort	tigar is correlated with maximal standardized uptake value on fdg-pet and survival in non-small cell lung cancer.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/fefbbebbcf2549c29896420c5c829451
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TIGAR is correlated with maximal standardized uptake value on FDG-PET and survival in non-small cell lung cancer.

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