Perturbation of BRMS1 interactome reveals pathways that impact metastasis.
Breast Cancer Metastasis Suppressor 1 (BRMS1) expression is associated with longer patient survival in multiple cancer types. Understanding BRMS1 functionality will provide insights into both mechanism of action and will enhance potential therapeutic development. In this study, we confirmed that the...
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Public Library of Science (PLoS)
2021
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oai:doaj.org-article:fefc02ab41c149a6bc560619b23062322021-12-02T20:12:58ZPerturbation of BRMS1 interactome reveals pathways that impact metastasis.1932-620310.1371/journal.pone.0259128https://doaj.org/article/fefc02ab41c149a6bc560619b23062322021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0259128https://doaj.org/toc/1932-6203Breast Cancer Metastasis Suppressor 1 (BRMS1) expression is associated with longer patient survival in multiple cancer types. Understanding BRMS1 functionality will provide insights into both mechanism of action and will enhance potential therapeutic development. In this study, we confirmed that the C-terminus of BRMS1 is critical for metastasis suppression and hypothesized that critical protein interactions in this region would explain its function. Phosphorylation status at S237 regulates BRMS1 protein interactions related to a variety of biological processes, phenotypes [cell cycle (e.g., CDKN2A), DNA repair (e.g., BRCA1)], and metastasis [(e.g., TCF2 and POLE2)]. Presence of S237 also directly decreased MDA-MB-231 breast carcinoma migration in vitro and metastases in vivo. The results add significantly to our understanding of how BRMS1 interactions with Sin3/HDAC complexes regulate metastasis and expand insights into BRMS1's molecular role, as they demonstrate BRMS1 C-terminus involvement in distinct protein-protein interactions.Rosalyn C ZimmermannMihaela E SardiuChrista A MantonMd Sayem MiahCharles A S BanksMark K AdamsDevin C KoestlerDouglas R HurstMick D EdmondsMichael P WashburnDanny R WelchPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0259128 (2021) |
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EN |
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Medicine R Science Q |
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Medicine R Science Q Rosalyn C Zimmermann Mihaela E Sardiu Christa A Manton Md Sayem Miah Charles A S Banks Mark K Adams Devin C Koestler Douglas R Hurst Mick D Edmonds Michael P Washburn Danny R Welch Perturbation of BRMS1 interactome reveals pathways that impact metastasis. |
| description |
Breast Cancer Metastasis Suppressor 1 (BRMS1) expression is associated with longer patient survival in multiple cancer types. Understanding BRMS1 functionality will provide insights into both mechanism of action and will enhance potential therapeutic development. In this study, we confirmed that the C-terminus of BRMS1 is critical for metastasis suppression and hypothesized that critical protein interactions in this region would explain its function. Phosphorylation status at S237 regulates BRMS1 protein interactions related to a variety of biological processes, phenotypes [cell cycle (e.g., CDKN2A), DNA repair (e.g., BRCA1)], and metastasis [(e.g., TCF2 and POLE2)]. Presence of S237 also directly decreased MDA-MB-231 breast carcinoma migration in vitro and metastases in vivo. The results add significantly to our understanding of how BRMS1 interactions with Sin3/HDAC complexes regulate metastasis and expand insights into BRMS1's molecular role, as they demonstrate BRMS1 C-terminus involvement in distinct protein-protein interactions. |
| format |
article |
| author |
Rosalyn C Zimmermann Mihaela E Sardiu Christa A Manton Md Sayem Miah Charles A S Banks Mark K Adams Devin C Koestler Douglas R Hurst Mick D Edmonds Michael P Washburn Danny R Welch |
| author_facet |
Rosalyn C Zimmermann Mihaela E Sardiu Christa A Manton Md Sayem Miah Charles A S Banks Mark K Adams Devin C Koestler Douglas R Hurst Mick D Edmonds Michael P Washburn Danny R Welch |
| author_sort |
Rosalyn C Zimmermann |
| title |
Perturbation of BRMS1 interactome reveals pathways that impact metastasis. |
| title_short |
Perturbation of BRMS1 interactome reveals pathways that impact metastasis. |
| title_full |
Perturbation of BRMS1 interactome reveals pathways that impact metastasis. |
| title_fullStr |
Perturbation of BRMS1 interactome reveals pathways that impact metastasis. |
| title_full_unstemmed |
Perturbation of BRMS1 interactome reveals pathways that impact metastasis. |
| title_sort |
perturbation of brms1 interactome reveals pathways that impact metastasis. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2021 |
| url |
https://doaj.org/article/fefc02ab41c149a6bc560619b2306232 |
| work_keys_str_mv |
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