DISTURBANCE OF THE PROGESTERONE AND ITS METABOLITES SYNTHESIS IN THE DEVELOPMENT OF NEUROLOGICAL DISORDERS IN CHILDREN AFTER CYTOMEGALOVIRUS INFECTION DURING PREGNANCY

Cytomegalovirus (CMV) infection is one of the causes of congenital neurological disorders and the virus itself is the most common viral agent causing an imbalance in the production of placenta progesterone and its neuroactive metabolites – allopregnenolone and 5α-dihydroprogesterone. The aim was t...

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Autores principales:	I. V. Dovzhikova, I. A. Andrievskaya, N. A. Ishutina, I. N. Gorikov, S. V. Medvedeva, M. T. Lutsenko
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2018
Materias:	cytomegalovirus infection placenta pregnancy progesterone 5-dihydroprogesterone allopregnenolone neonatal infants perinatal central nerv ous system lesions Science Q
Acceso en línea:	https://doaj.org/article/ff0306a607874c6cab0a7945912aa6d5
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spelling	oai:doaj.org-article:ff0306a607874c6cab0a7945912aa6d52021-11-23T06:14:41ZDISTURBANCE OF THE PROGESTERONE AND ITS METABOLITES SYNTHESIS IN THE DEVELOPMENT OF NEUROLOGICAL DISORDERS IN CHILDREN AFTER CYTOMEGALOVIRUS INFECTION DURING PREGNANCY2541-94202587-959610.29413/ABS.2018-3.4.12https://doaj.org/article/ff0306a607874c6cab0a7945912aa6d52018-07-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/653https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Cytomegalovirus (CMV) infection is one of the causes of congenital neurological disorders and the virus itself is the most common viral agent causing an imbalance in the production of placenta progesterone and its neuroactive metabolites – allopregnenolone and 5α-dihydroprogesterone. The aim was to evaluate the concentration of progesterone and its metabolites – 5α-dihydroprogesterone and allopregnenolone – in placenta during exacerbation of CMV infection in the first trimester of pregnancy, and the impact of these disturbances on the development of neurological disorders in children. We examined 30 pregnant women with exacerbation of CMV infection in the first trimester of pregnancy and 30 pregnant women with latent disease; and later their newborns. The enzyme immunoassay was used to determine concentration of progesterone in placenta; the histochemical method – to determine 5α-dihydroprogesterone and allopregnenolone. Newborns underwent neurosonography studies. Exacerbation of CMV infection in the first trimester of pregnancy decreased progesterone in placenta by 1.3 times, 5α-dihydroprogesterone – by 1.73 times and allopregnenolone – by 2 times. Ultrasound examination of the brain showed ventriculomegaly, periventricular ischemia, and pseudocysts in newborns up to one year from mothers with exacerbation of CMV during pregnancy. Later, minimal brain dysfunctions were manifested by motor disorders, increased general, vegetative excitability, and a tendency to digestive and sleep disorders. The data obtained indicate that the exacerbation of CMV infection in the first trimester of pregnancy is interrelated with a decrease in the concentration of progesterone and its metabolites (5α-dihydroprogesterone, allopregnenolone) in the placenta and development of neurological dysfunction in newborns.I. V. DovzhikovaI. A. AndrievskayaN. A. IshutinaI. N. GorikovS. V. MedvedevaM. T. LutsenkoScientific Сentre for Family Health and Human Reproduction Problemsarticlecytomegalovirus infectionplacentapregnancyprogesterone5-dihydroprogesteroneallopregnenoloneneonatal infantsperinatal central nerv ous system lesionsScienceQRUActa Biomedica Scientifica, Vol 3, Iss 4, Pp 78-84 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	cytomegalovirus infection placenta pregnancy progesterone 5-dihydroprogesterone allopregnenolone neonatal infants perinatal central nerv ous system lesions Science Q
spellingShingle	cytomegalovirus infection placenta pregnancy progesterone 5-dihydroprogesterone allopregnenolone neonatal infants perinatal central nerv ous system lesions Science Q I. V. Dovzhikova I. A. Andrievskaya N. A. Ishutina I. N. Gorikov S. V. Medvedeva M. T. Lutsenko DISTURBANCE OF THE PROGESTERONE AND ITS METABOLITES SYNTHESIS IN THE DEVELOPMENT OF NEUROLOGICAL DISORDERS IN CHILDREN AFTER CYTOMEGALOVIRUS INFECTION DURING PREGNANCY
description	Cytomegalovirus (CMV) infection is one of the causes of congenital neurological disorders and the virus itself is the most common viral agent causing an imbalance in the production of placenta progesterone and its neuroactive metabolites – allopregnenolone and 5α-dihydroprogesterone. The aim was to evaluate the concentration of progesterone and its metabolites – 5α-dihydroprogesterone and allopregnenolone – in placenta during exacerbation of CMV infection in the first trimester of pregnancy, and the impact of these disturbances on the development of neurological disorders in children. We examined 30 pregnant women with exacerbation of CMV infection in the first trimester of pregnancy and 30 pregnant women with latent disease; and later their newborns. The enzyme immunoassay was used to determine concentration of progesterone in placenta; the histochemical method – to determine 5α-dihydroprogesterone and allopregnenolone. Newborns underwent neurosonography studies. Exacerbation of CMV infection in the first trimester of pregnancy decreased progesterone in placenta by 1.3 times, 5α-dihydroprogesterone – by 1.73 times and allopregnenolone – by 2 times. Ultrasound examination of the brain showed ventriculomegaly, periventricular ischemia, and pseudocysts in newborns up to one year from mothers with exacerbation of CMV during pregnancy. Later, minimal brain dysfunctions were manifested by motor disorders, increased general, vegetative excitability, and a tendency to digestive and sleep disorders. The data obtained indicate that the exacerbation of CMV infection in the first trimester of pregnancy is interrelated with a decrease in the concentration of progesterone and its metabolites (5α-dihydroprogesterone, allopregnenolone) in the placenta and development of neurological dysfunction in newborns.
format	article
author	I. V. Dovzhikova I. A. Andrievskaya N. A. Ishutina I. N. Gorikov S. V. Medvedeva M. T. Lutsenko
author_facet	I. V. Dovzhikova I. A. Andrievskaya N. A. Ishutina I. N. Gorikov S. V. Medvedeva M. T. Lutsenko
author_sort	I. V. Dovzhikova
title	DISTURBANCE OF THE PROGESTERONE AND ITS METABOLITES SYNTHESIS IN THE DEVELOPMENT OF NEUROLOGICAL DISORDERS IN CHILDREN AFTER CYTOMEGALOVIRUS INFECTION DURING PREGNANCY
title_short	DISTURBANCE OF THE PROGESTERONE AND ITS METABOLITES SYNTHESIS IN THE DEVELOPMENT OF NEUROLOGICAL DISORDERS IN CHILDREN AFTER CYTOMEGALOVIRUS INFECTION DURING PREGNANCY
title_full	DISTURBANCE OF THE PROGESTERONE AND ITS METABOLITES SYNTHESIS IN THE DEVELOPMENT OF NEUROLOGICAL DISORDERS IN CHILDREN AFTER CYTOMEGALOVIRUS INFECTION DURING PREGNANCY
title_fullStr	DISTURBANCE OF THE PROGESTERONE AND ITS METABOLITES SYNTHESIS IN THE DEVELOPMENT OF NEUROLOGICAL DISORDERS IN CHILDREN AFTER CYTOMEGALOVIRUS INFECTION DURING PREGNANCY
title_full_unstemmed	DISTURBANCE OF THE PROGESTERONE AND ITS METABOLITES SYNTHESIS IN THE DEVELOPMENT OF NEUROLOGICAL DISORDERS IN CHILDREN AFTER CYTOMEGALOVIRUS INFECTION DURING PREGNANCY
title_sort	disturbance of the progesterone and its metabolites synthesis in the development of neurological disorders in children after cytomegalovirus infection during pregnancy
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2018
url	https://doaj.org/article/ff0306a607874c6cab0a7945912aa6d5
work_keys_str_mv	AT ivdovzhikova disturbanceoftheprogesteroneanditsmetabolitessynthesisinthedevelopmentofneurologicaldisordersinchildrenaftercytomegalovirusinfectionduringpregnancy AT iaandrievskaya disturbanceoftheprogesteroneanditsmetabolitessynthesisinthedevelopmentofneurologicaldisordersinchildrenaftercytomegalovirusinfectionduringpregnancy AT naishutina disturbanceoftheprogesteroneanditsmetabolitessynthesisinthedevelopmentofneurologicaldisordersinchildrenaftercytomegalovirusinfectionduringpregnancy AT ingorikov disturbanceoftheprogesteroneanditsmetabolitessynthesisinthedevelopmentofneurologicaldisordersinchildrenaftercytomegalovirusinfectionduringpregnancy AT svmedvedeva disturbanceoftheprogesteroneanditsmetabolitessynthesisinthedevelopmentofneurologicaldisordersinchildrenaftercytomegalovirusinfectionduringpregnancy AT mtlutsenko disturbanceoftheprogesteroneanditsmetabolitessynthesisinthedevelopmentofneurologicaldisordersinchildrenaftercytomegalovirusinfectionduringpregnancy
_version_	1718416986939064320

DISTURBANCE OF THE PROGESTERONE AND ITS METABOLITES SYNTHESIS IN THE DEVELOPMENT OF NEUROLOGICAL DISORDERS IN CHILDREN AFTER CYTOMEGALOVIRUS INFECTION DURING PREGNANCY

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