An inner activation gate controls TMEM16F phospholipid scrambling
TMEM16F is an enigmatic Ca2 + -activated phospholipid scramblase (CaPLSase) that passively transports phospholipids. Here authors identify an inner activation gate and its disruption profoundly alters TMEM16F phospholipid permeation.
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Autores principales: | Trieu Le, Zhiguang Jia, Son C. Le, Yang Zhang, Jianhan Chen, Huanghe Yang |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2019
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Materias: | |
Acceso en línea: | https://doaj.org/article/ff04ecc72037485988bec5dbf32407c6 |
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