A MST1–FOXO1 cascade establishes endothelial tip cell polarity and facilitates sprouting angiogenesis

Angiogenesis is driven by the directed migration of tip endothelial cells towards hypoxic tissues. Here, Kim et al. show that the generation of reactive oxygen species in endothelial cells upon hypoxia activates MST1, which subsequently promotes the nuclear translocation of FOXO1, and thus activates...

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Autores principales:	Yoo Hyung Kim, Jeongwoon Choi, Myung Jin Yang, Seon Pyo Hong, Choong-kun Lee, Yoshiaki Kubota, Dae-Sik Lim, Gou Young Koh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ff05290b95594556b9afa965bdd2d71b
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spelling	oai:doaj.org-article:ff05290b95594556b9afa965bdd2d71b2021-12-02T16:58:05ZA MST1–FOXO1 cascade establishes endothelial tip cell polarity and facilitates sprouting angiogenesis10.1038/s41467-019-08773-22041-1723https://doaj.org/article/ff05290b95594556b9afa965bdd2d71b2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08773-2https://doaj.org/toc/2041-1723Angiogenesis is driven by the directed migration of tip endothelial cells towards hypoxic tissues. Here, Kim et al. show that the generation of reactive oxygen species in endothelial cells upon hypoxia activates MST1, which subsequently promotes the nuclear translocation of FOXO1, and thus activates a pro-migratory transcriptional programme in endothelial tip cells.Yoo Hyung KimJeongwoon ChoiMyung Jin YangSeon Pyo HongChoong-kun LeeYoshiaki KubotaDae-Sik LimGou Young KohNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yoo Hyung Kim Jeongwoon Choi Myung Jin Yang Seon Pyo Hong Choong-kun Lee Yoshiaki Kubota Dae-Sik Lim Gou Young Koh A MST1–FOXO1 cascade establishes endothelial tip cell polarity and facilitates sprouting angiogenesis
description	Angiogenesis is driven by the directed migration of tip endothelial cells towards hypoxic tissues. Here, Kim et al. show that the generation of reactive oxygen species in endothelial cells upon hypoxia activates MST1, which subsequently promotes the nuclear translocation of FOXO1, and thus activates a pro-migratory transcriptional programme in endothelial tip cells.
format	article
author	Yoo Hyung Kim Jeongwoon Choi Myung Jin Yang Seon Pyo Hong Choong-kun Lee Yoshiaki Kubota Dae-Sik Lim Gou Young Koh
author_facet	Yoo Hyung Kim Jeongwoon Choi Myung Jin Yang Seon Pyo Hong Choong-kun Lee Yoshiaki Kubota Dae-Sik Lim Gou Young Koh
author_sort	Yoo Hyung Kim
title	A MST1–FOXO1 cascade establishes endothelial tip cell polarity and facilitates sprouting angiogenesis
title_short	A MST1–FOXO1 cascade establishes endothelial tip cell polarity and facilitates sprouting angiogenesis
title_full	A MST1–FOXO1 cascade establishes endothelial tip cell polarity and facilitates sprouting angiogenesis
title_fullStr	A MST1–FOXO1 cascade establishes endothelial tip cell polarity and facilitates sprouting angiogenesis
title_full_unstemmed	A MST1–FOXO1 cascade establishes endothelial tip cell polarity and facilitates sprouting angiogenesis
title_sort	mst1–foxo1 cascade establishes endothelial tip cell polarity and facilitates sprouting angiogenesis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ff05290b95594556b9afa965bdd2d71b
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A MST1–FOXO1 cascade establishes endothelial tip cell polarity and facilitates sprouting angiogenesis

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