A MST1–FOXO1 cascade establishes endothelial tip cell polarity and facilitates sprouting angiogenesis

A MST1–FOXO1 cascade establishes endothelial tip cell polarity and facilitates sprouting angiogenesis

Angiogenesis is driven by the directed migration of tip endothelial cells towards hypoxic tissues. Here, Kim et al. show that the generation of reactive oxygen species in endothelial cells upon hypoxia activates MST1, which subsequently promotes the nuclear translocation of FOXO1, and thus activates...

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Autores principales: Yoo Hyung Kim, Jeongwoon Choi, Myung Jin Yang, Seon Pyo Hong, Choong-kun Lee, Yoshiaki Kubota, Dae-Sik Lim, Gou Young Koh
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/ff05290b95594556b9afa965bdd2d71b
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