Phenylalanine Butyramide Is a New Cosmetic Ingredient with Soothing and Anti-Reddening Potential

Human skin is colonized by diverse commensal microbes, making up the skin microbiota (SM), contributing to skin integrity and homeostasis. Many of the beneficial effects aroused by the SM are exerted by microbial metabolites such as short-chain fatty acids (SCFAs), including butyric acid. The SCFAs...

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Autores principales:	Ritamaria di Lorenzo, Antonietta Bernardi, Lucia Grumetto, Antonia Sacchi, Carmen Avagliano, Serena Coppola, Anna Fiorenza de Giovanni di Santa Severina, Cristina Bruno, Lorella Paparo, Sonia Laneri, Irene Dini
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	butyrate skin microbiota skin permeation erythema index soothing and anti-reddening effect Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/ff0593684a7d493bbc19daac95075d74
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spelling	oai:doaj.org-article:ff0593684a7d493bbc19daac95075d742021-11-11T18:34:57ZPhenylalanine Butyramide Is a New Cosmetic Ingredient with Soothing and Anti-Reddening Potential10.3390/molecules262166111420-3049https://doaj.org/article/ff0593684a7d493bbc19daac95075d742021-10-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6611https://doaj.org/toc/1420-3049Human skin is colonized by diverse commensal microbes, making up the skin microbiota (SM), contributing to skin integrity and homeostasis. Many of the beneficial effects aroused by the SM are exerted by microbial metabolites such as short-chain fatty acids (SCFAs), including butyric acid. The SCFAs can be used in cosmetic formulations against skin diseases to protect SM by preserving and/or restoring their natural balance. Unpleasant sensorial properties and unfavorable physico-chemical properties of butyrate strongly limit its cosmetic use. In contrast, some butyrate derivatives, including phenylalanine butyramide (C<sub>13</sub>H<sub>18</sub>N<sub>2</sub>O<sub>2</sub>, FBA), a solid form of butyric acid, are odorless while retaining the pharmacokinetic properties and safety profile of butyric acid. This study assessed the FBA’s permeation across the skin and its soothing and anti-reddening potential to estimate its cosmetic application. The dosage method used to estimate FBA’s levels was validated to be sure of analytical results. The FBA diffusion tests were estimated in vitro using a Franz-type vertical diffusion cell. The soothing action was evaluated in vivo by Colorimeter CL400, measuring the erythema index. The results suggest that the FBA represents an innovative way to exploit the benefits of butyric acid in the cosmetic fields since it cannot reach the bloodstream, is odorless, and has a significative soothing action (decrease the erythema index −15.7% after 30′, and −17.8% after 60′).Ritamaria di LorenzoAntonietta BernardiLucia GrumettoAntonia SacchiCarmen AvaglianoSerena CoppolaAnna Fiorenza de Giovanni di Santa SeverinaCristina BrunoLorella PaparoSonia LaneriIrene DiniMDPI AGarticlebutyrateskin microbiotaskin permeationerythema indexsoothing and anti-reddening effectOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6611, p 6611 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	butyrate skin microbiota skin permeation erythema index soothing and anti-reddening effect Organic chemistry QD241-441
spellingShingle	butyrate skin microbiota skin permeation erythema index soothing and anti-reddening effect Organic chemistry QD241-441 Ritamaria di Lorenzo Antonietta Bernardi Lucia Grumetto Antonia Sacchi Carmen Avagliano Serena Coppola Anna Fiorenza de Giovanni di Santa Severina Cristina Bruno Lorella Paparo Sonia Laneri Irene Dini Phenylalanine Butyramide Is a New Cosmetic Ingredient with Soothing and Anti-Reddening Potential
description	Human skin is colonized by diverse commensal microbes, making up the skin microbiota (SM), contributing to skin integrity and homeostasis. Many of the beneficial effects aroused by the SM are exerted by microbial metabolites such as short-chain fatty acids (SCFAs), including butyric acid. The SCFAs can be used in cosmetic formulations against skin diseases to protect SM by preserving and/or restoring their natural balance. Unpleasant sensorial properties and unfavorable physico-chemical properties of butyrate strongly limit its cosmetic use. In contrast, some butyrate derivatives, including phenylalanine butyramide (C<sub>13</sub>H<sub>18</sub>N<sub>2</sub>O<sub>2</sub>, FBA), a solid form of butyric acid, are odorless while retaining the pharmacokinetic properties and safety profile of butyric acid. This study assessed the FBA’s permeation across the skin and its soothing and anti-reddening potential to estimate its cosmetic application. The dosage method used to estimate FBA’s levels was validated to be sure of analytical results. The FBA diffusion tests were estimated in vitro using a Franz-type vertical diffusion cell. The soothing action was evaluated in vivo by Colorimeter CL400, measuring the erythema index. The results suggest that the FBA represents an innovative way to exploit the benefits of butyric acid in the cosmetic fields since it cannot reach the bloodstream, is odorless, and has a significative soothing action (decrease the erythema index −15.7% after 30′, and −17.8% after 60′).
format	article
author	Ritamaria di Lorenzo Antonietta Bernardi Lucia Grumetto Antonia Sacchi Carmen Avagliano Serena Coppola Anna Fiorenza de Giovanni di Santa Severina Cristina Bruno Lorella Paparo Sonia Laneri Irene Dini
author_facet	Ritamaria di Lorenzo Antonietta Bernardi Lucia Grumetto Antonia Sacchi Carmen Avagliano Serena Coppola Anna Fiorenza de Giovanni di Santa Severina Cristina Bruno Lorella Paparo Sonia Laneri Irene Dini
author_sort	Ritamaria di Lorenzo
title	Phenylalanine Butyramide Is a New Cosmetic Ingredient with Soothing and Anti-Reddening Potential
title_short	Phenylalanine Butyramide Is a New Cosmetic Ingredient with Soothing and Anti-Reddening Potential
title_full	Phenylalanine Butyramide Is a New Cosmetic Ingredient with Soothing and Anti-Reddening Potential
title_fullStr	Phenylalanine Butyramide Is a New Cosmetic Ingredient with Soothing and Anti-Reddening Potential
title_full_unstemmed	Phenylalanine Butyramide Is a New Cosmetic Ingredient with Soothing and Anti-Reddening Potential
title_sort	phenylalanine butyramide is a new cosmetic ingredient with soothing and anti-reddening potential
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ff0593684a7d493bbc19daac95075d74
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Phenylalanine Butyramide Is a New Cosmetic Ingredient with Soothing and Anti-Reddening Potential

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