Predicting respiratory failure in patients infected by SARS-CoV-2 by admission sex-specific biomarkers
Abstract Background Several biomarkers have been identified to predict the outcome of COVID-19 severity, but few data are available regarding sex differences in their predictive role. Aim of this study was to identify sex-specific biomarkers of severity and progression of acute respiratory distress...
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BMC
2021
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oai:doaj.org-article:ff0e1e9b856b4ce7a4e9ce04fdd1dc062021-11-28T12:04:04ZPredicting respiratory failure in patients infected by SARS-CoV-2 by admission sex-specific biomarkers10.1186/s13293-021-00407-x2042-6410https://doaj.org/article/ff0e1e9b856b4ce7a4e9ce04fdd1dc062021-11-01T00:00:00Zhttps://doi.org/10.1186/s13293-021-00407-xhttps://doaj.org/toc/2042-6410Abstract Background Several biomarkers have been identified to predict the outcome of COVID-19 severity, but few data are available regarding sex differences in their predictive role. Aim of this study was to identify sex-specific biomarkers of severity and progression of acute respiratory distress syndrome (ARDS) in COVID-19. Methods Plasma levels of sex hormones (testosterone and 17β-estradiol), sex-hormone dependent circulating molecules (ACE2 and Angiotensin1-7) and other known biomarkers for COVID-19 severity were measured in male and female COVID-19 patients at admission to hospital. The association of plasma biomarker levels with ARDS severity at admission and with the occurrence of respiratory deterioration during hospitalization was analysed in aggregated and sex disaggregated form. Results Our data show that some biomarkers could be predictive both for males and female patients and others only for one sex. Angiotensin1-7 plasma levels and neutrophil count predicted the outcome of ARDS only in females, whereas testosterone plasma levels and lymphocytes counts only in males. Conclusions Sex is a biological variable affecting the choice of the correct biomarker that might predict worsening of COVID-19 to severe respiratory failure. The definition of sex specific biomarkers can be useful to alert patients to be safely discharged versus those who need respiratory monitoring.Maria Teresa PaganoDaniela PeruzzuLuca BusaniMarina PierdominiciAnna RuggieriAndrea AntinoriGianpiero D’OffiziNicola PetrosilloFabrizio PalmieriPierluca PiselliStefania CicaliniStefania NotariEmanuele NicastriChiara AgratiGiuseppe IppolitoFrancesco VaiaMaria Cristina GagliardiMaria Rosaria CapobianchiElena OrtonaINMI-ISS COVID-19 teamBMCarticleBiomarkersSexGenderCOVID-19TestosteroneEstrogenMedicineRPhysiologyQP1-981ENBiology of Sex Differences, Vol 12, Iss 1, Pp 1-12 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Biomarkers Sex Gender COVID-19 Testosterone Estrogen Medicine R Physiology QP1-981 |
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Biomarkers Sex Gender COVID-19 Testosterone Estrogen Medicine R Physiology QP1-981 Maria Teresa Pagano Daniela Peruzzu Luca Busani Marina Pierdominici Anna Ruggieri Andrea Antinori Gianpiero D’Offizi Nicola Petrosillo Fabrizio Palmieri Pierluca Piselli Stefania Cicalini Stefania Notari Emanuele Nicastri Chiara Agrati Giuseppe Ippolito Francesco Vaia Maria Cristina Gagliardi Maria Rosaria Capobianchi Elena Ortona INMI-ISS COVID-19 team Predicting respiratory failure in patients infected by SARS-CoV-2 by admission sex-specific biomarkers |
| description |
Abstract Background Several biomarkers have been identified to predict the outcome of COVID-19 severity, but few data are available regarding sex differences in their predictive role. Aim of this study was to identify sex-specific biomarkers of severity and progression of acute respiratory distress syndrome (ARDS) in COVID-19. Methods Plasma levels of sex hormones (testosterone and 17β-estradiol), sex-hormone dependent circulating molecules (ACE2 and Angiotensin1-7) and other known biomarkers for COVID-19 severity were measured in male and female COVID-19 patients at admission to hospital. The association of plasma biomarker levels with ARDS severity at admission and with the occurrence of respiratory deterioration during hospitalization was analysed in aggregated and sex disaggregated form. Results Our data show that some biomarkers could be predictive both for males and female patients and others only for one sex. Angiotensin1-7 plasma levels and neutrophil count predicted the outcome of ARDS only in females, whereas testosterone plasma levels and lymphocytes counts only in males. Conclusions Sex is a biological variable affecting the choice of the correct biomarker that might predict worsening of COVID-19 to severe respiratory failure. The definition of sex specific biomarkers can be useful to alert patients to be safely discharged versus those who need respiratory monitoring. |
| format |
article |
| author |
Maria Teresa Pagano Daniela Peruzzu Luca Busani Marina Pierdominici Anna Ruggieri Andrea Antinori Gianpiero D’Offizi Nicola Petrosillo Fabrizio Palmieri Pierluca Piselli Stefania Cicalini Stefania Notari Emanuele Nicastri Chiara Agrati Giuseppe Ippolito Francesco Vaia Maria Cristina Gagliardi Maria Rosaria Capobianchi Elena Ortona INMI-ISS COVID-19 team |
| author_facet |
Maria Teresa Pagano Daniela Peruzzu Luca Busani Marina Pierdominici Anna Ruggieri Andrea Antinori Gianpiero D’Offizi Nicola Petrosillo Fabrizio Palmieri Pierluca Piselli Stefania Cicalini Stefania Notari Emanuele Nicastri Chiara Agrati Giuseppe Ippolito Francesco Vaia Maria Cristina Gagliardi Maria Rosaria Capobianchi Elena Ortona INMI-ISS COVID-19 team |
| author_sort |
Maria Teresa Pagano |
| title |
Predicting respiratory failure in patients infected by SARS-CoV-2 by admission sex-specific biomarkers |
| title_short |
Predicting respiratory failure in patients infected by SARS-CoV-2 by admission sex-specific biomarkers |
| title_full |
Predicting respiratory failure in patients infected by SARS-CoV-2 by admission sex-specific biomarkers |
| title_fullStr |
Predicting respiratory failure in patients infected by SARS-CoV-2 by admission sex-specific biomarkers |
| title_full_unstemmed |
Predicting respiratory failure in patients infected by SARS-CoV-2 by admission sex-specific biomarkers |
| title_sort |
predicting respiratory failure in patients infected by sars-cov-2 by admission sex-specific biomarkers |
| publisher |
BMC |
| publishDate |
2021 |
| url |
https://doaj.org/article/ff0e1e9b856b4ce7a4e9ce04fdd1dc06 |
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