Successful treatment of syphilitic uveitis in HIV-positive patients

Mohd-Jamil Nurfahzura,1–3 Hashim Hanizasurana,1 Embong Zunaina,2,3 Hussein Adil2,3 1Department of Ophthalmology, Hospital Selayang, Lebuhraya Selayang-Kepong, Selangor, Malaysia; 2Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia; 3Hospi...

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Autores principales:	Nurfahzura MJ, Hanizasurana H, Zunaina E, Adil H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/ff0f6ed7c84a4a6caa68c46e5a8f6767
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spelling	oai:doaj.org-article:ff0f6ed7c84a4a6caa68c46e5a8f67672021-12-02T08:38:00ZSuccessful treatment of syphilitic uveitis in HIV-positive patients1177-54671177-5483https://doaj.org/article/ff0f6ed7c84a4a6caa68c46e5a8f67672013-08-01T00:00:00Zhttp://www.dovepress.com/successful-treatment-of-syphilitic-uveitis-in-hiv-positive-patients-a14094https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Mohd-Jamil Nurfahzura,1–3 Hashim Hanizasurana,1 Embong Zunaina,2,3 Hussein Adil2,3 1Department of Ophthalmology, Hospital Selayang, Lebuhraya Selayang-Kepong, Selangor, Malaysia; 2Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia; 3Hospital Universiti Sains Malaysia, Jalan Raja Perempuan Zainab II, Kelantan, Malaysia Abstract: We report successful treatment of syphilitic uveitis in a case series of three Human immunodeficiency virus (HIV)-positive patients at Malaysia's Selayang Hospital eye clinic. All three patients with syphilitic uveitis were male, aged from 23 to 35 years old, with a history of high-risk behaviors. Of the patients, two presented with blurring of vision and only one patient presented with floaters in the affected eye. Ocular examination revealed intermediate uveitis (case 1 and case 3) and panuveitis (case 2). Each patient showed a high Venereal Disease Research Laboratory (VDRL) titer at presentation and they were also newly diagnosed as HIV positive with variable CD4 counts. All three patients responded well to a neurosyphilis regimen of intravenous penicillin G. At 3 months posttreatment, there was reduction in VDRL titer with improvement of vision in the affected eye. Diagnosis of syphilis needs to be ruled out in all cases of uveitis. All syphilitic uveitis cases should have HIV screening and vice versa, as syphilis is one of the most common infectious diseases associated with HIV-positive patients. Early detection and treatment are important for a good visual outcome. Keywords: syphilitic uveitis, penicillin, neurosyphilis, HIV-positive patientNurfahzura MJHanizasurana HZunaina EAdil HDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 1651-1654 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Nurfahzura MJ Hanizasurana H Zunaina E Adil H Successful treatment of syphilitic uveitis in HIV-positive patients
description	Mohd-Jamil Nurfahzura,1–3 Hashim Hanizasurana,1 Embong Zunaina,2,3 Hussein Adil2,3 1Department of Ophthalmology, Hospital Selayang, Lebuhraya Selayang-Kepong, Selangor, Malaysia; 2Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia; 3Hospital Universiti Sains Malaysia, Jalan Raja Perempuan Zainab II, Kelantan, Malaysia Abstract: We report successful treatment of syphilitic uveitis in a case series of three Human immunodeficiency virus (HIV)-positive patients at Malaysia's Selayang Hospital eye clinic. All three patients with syphilitic uveitis were male, aged from 23 to 35 years old, with a history of high-risk behaviors. Of the patients, two presented with blurring of vision and only one patient presented with floaters in the affected eye. Ocular examination revealed intermediate uveitis (case 1 and case 3) and panuveitis (case 2). Each patient showed a high Venereal Disease Research Laboratory (VDRL) titer at presentation and they were also newly diagnosed as HIV positive with variable CD4 counts. All three patients responded well to a neurosyphilis regimen of intravenous penicillin G. At 3 months posttreatment, there was reduction in VDRL titer with improvement of vision in the affected eye. Diagnosis of syphilis needs to be ruled out in all cases of uveitis. All syphilitic uveitis cases should have HIV screening and vice versa, as syphilis is one of the most common infectious diseases associated with HIV-positive patients. Early detection and treatment are important for a good visual outcome. Keywords: syphilitic uveitis, penicillin, neurosyphilis, HIV-positive patient
format	article
author	Nurfahzura MJ Hanizasurana H Zunaina E Adil H
author_facet	Nurfahzura MJ Hanizasurana H Zunaina E Adil H
author_sort	Nurfahzura MJ
title	Successful treatment of syphilitic uveitis in HIV-positive patients
title_short	Successful treatment of syphilitic uveitis in HIV-positive patients
title_full	Successful treatment of syphilitic uveitis in HIV-positive patients
title_fullStr	Successful treatment of syphilitic uveitis in HIV-positive patients
title_full_unstemmed	Successful treatment of syphilitic uveitis in HIV-positive patients
title_sort	successful treatment of syphilitic uveitis in hiv-positive patients
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/ff0f6ed7c84a4a6caa68c46e5a8f6767
work_keys_str_mv	AT nurfahzuramj successfultreatmentofsyphiliticuveitisinhivpositivepatients AT hanizasuranah successfultreatmentofsyphiliticuveitisinhivpositivepatients AT zunainae successfultreatmentofsyphiliticuveitisinhivpositivepatients AT adilh successfultreatmentofsyphiliticuveitisinhivpositivepatients
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Successful treatment of syphilitic uveitis in HIV-positive patients

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