A tripartite synapse model in Drosophila.

Tripartite (three-part) synapses are defined by physical and functional interactions of glia with pre- and post-synaptic elements. Although tripartite synapses are thought to be of widespread importance in neurological health and disease, we are only beginning to develop an understanding of glial co...

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Autores principales:	Rie Danjo, Fumiko Kawasaki, Richard W Ordway
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ff101e9e0f6c48d8ba654e01bd9da65d
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id	oai:doaj.org-article:ff101e9e0f6c48d8ba654e01bd9da65d
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spelling	oai:doaj.org-article:ff101e9e0f6c48d8ba654e01bd9da65d2021-11-18T06:58:43ZA tripartite synapse model in Drosophila.1932-620310.1371/journal.pone.0017131https://doaj.org/article/ff101e9e0f6c48d8ba654e01bd9da65d2011-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21359186/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Tripartite (three-part) synapses are defined by physical and functional interactions of glia with pre- and post-synaptic elements. Although tripartite synapses are thought to be of widespread importance in neurological health and disease, we are only beginning to develop an understanding of glial contributions to synaptic function. In contrast to studies of neuronal mechanisms, a significant limitation has been the lack of an invertebrate genetic model system in which conserved mechanisms of tripartite synapse function may be examined through large-scale application of forward genetics and genome-wide genetic tools. Here we report a Drosophila tripartite synapse model which exhibits morphological and functional properties similar to those of mammalian synapses, including glial regulation of extracellular glutamate, synaptically-induced glial calcium transients and glial coupling of synapses with tracheal structures mediating gas exchange. In combination with classical and cell-type specific genetic approaches in Drosophila, this model is expected to provide new insights into the molecular and cellular mechanisms of tripartite synapse function.Rie DanjoFumiko KawasakiRichard W OrdwayPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 2, p e17131 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rie Danjo Fumiko Kawasaki Richard W Ordway A tripartite synapse model in Drosophila.
description	Tripartite (three-part) synapses are defined by physical and functional interactions of glia with pre- and post-synaptic elements. Although tripartite synapses are thought to be of widespread importance in neurological health and disease, we are only beginning to develop an understanding of glial contributions to synaptic function. In contrast to studies of neuronal mechanisms, a significant limitation has been the lack of an invertebrate genetic model system in which conserved mechanisms of tripartite synapse function may be examined through large-scale application of forward genetics and genome-wide genetic tools. Here we report a Drosophila tripartite synapse model which exhibits morphological and functional properties similar to those of mammalian synapses, including glial regulation of extracellular glutamate, synaptically-induced glial calcium transients and glial coupling of synapses with tracheal structures mediating gas exchange. In combination with classical and cell-type specific genetic approaches in Drosophila, this model is expected to provide new insights into the molecular and cellular mechanisms of tripartite synapse function.
format	article
author	Rie Danjo Fumiko Kawasaki Richard W Ordway
author_facet	Rie Danjo Fumiko Kawasaki Richard W Ordway
author_sort	Rie Danjo
title	A tripartite synapse model in Drosophila.
title_short	A tripartite synapse model in Drosophila.
title_full	A tripartite synapse model in Drosophila.
title_fullStr	A tripartite synapse model in Drosophila.
title_full_unstemmed	A tripartite synapse model in Drosophila.
title_sort	tripartite synapse model in drosophila.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/ff101e9e0f6c48d8ba654e01bd9da65d
work_keys_str_mv	AT riedanjo atripartitesynapsemodelindrosophila AT fumikokawasaki atripartitesynapsemodelindrosophila AT richardwordway atripartitesynapsemodelindrosophila AT riedanjo tripartitesynapsemodelindrosophila AT fumikokawasaki tripartitesynapsemodelindrosophila AT richardwordway tripartitesynapsemodelindrosophila
_version_	1718424145510793216

A tripartite synapse model in Drosophila.

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