Role of central noradrenergic system on FSH secretion induced by excitatory Amino acids

Objective: Excitatory amino acids (EAA) and noradrenaline are known as a neurotransmitter, which stimulate gonadotropin secretion in female and male animals. This study was designed to evaluate the involvement of central noradrenaline system on FSH secretion induced by EAA in adult rats. Methods: Ra...

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Autores principales:	S Shahabi, AA Moghadam Nia
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2001
Materias:	central noradrenergic system locus coeruleus nucleus excitatory amino acid follicle stimulating hormone (fsh) rat Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ff11b5f5a9e34b21969a1911ddd78f3d
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spelling	oai:doaj.org-article:ff11b5f5a9e34b21969a1911ddd78f3d2021-11-10T09:20:53ZRole of central noradrenergic system on FSH secretion induced by excitatory Amino acids1561-41072251-7170https://doaj.org/article/ff11b5f5a9e34b21969a1911ddd78f3d2001-01-01T00:00:00Zhttp://jbums.org/article-1-2880-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170Objective: Excitatory amino acids (EAA) and noradrenaline are known as a neurotransmitter, which stimulate gonadotropin secretion in female and male animals. This study was designed to evaluate the involvement of central noradrenaline system on FSH secretion induced by EAA in adult rats. Methods: Rats were implanted with monolateral cannula through the LC-SC (Locus Coeruleus-Sub Coeruleus) by stereotaxy. Then saline or glutamate (2 mg/ml) was injected into the cannula. Blood samples were drawn just 10 min after injection and were prepared for IRMA (Immunoradiometric Assay). For investigating the involvement of LC-SC in noradrenergic system, DSP-4 was used as an injection bilaterally one week before glutamate. Findings: Microinjection of glutamate significantly increased the plasma level of FSH in comparison to saline in control group. Pretreatment with DSP-4 significantly decreased the plasma level of FSH before glutamate injection. Conclusion: The results indicated that LC-SC in adult rats is one of the major sites affected by EAAs on FSH secretion by noradrenergic neurons.S ShahabiAA Moghadam NiaBabol University of Medical Sciencesarticlecentral noradrenergic systemlocus coeruleus nucleusexcitatory amino acidfollicle stimulating hormone (fsh)ratMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 3, Iss 1, Pp 14-20 (2001)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	central noradrenergic system locus coeruleus nucleus excitatory amino acid follicle stimulating hormone (fsh) rat Medicine R Medicine (General) R5-920
spellingShingle	central noradrenergic system locus coeruleus nucleus excitatory amino acid follicle stimulating hormone (fsh) rat Medicine R Medicine (General) R5-920 S Shahabi AA Moghadam Nia Role of central noradrenergic system on FSH secretion induced by excitatory Amino acids
description	Objective: Excitatory amino acids (EAA) and noradrenaline are known as a neurotransmitter, which stimulate gonadotropin secretion in female and male animals. This study was designed to evaluate the involvement of central noradrenaline system on FSH secretion induced by EAA in adult rats. Methods: Rats were implanted with monolateral cannula through the LC-SC (Locus Coeruleus-Sub Coeruleus) by stereotaxy. Then saline or glutamate (2 mg/ml) was injected into the cannula. Blood samples were drawn just 10 min after injection and were prepared for IRMA (Immunoradiometric Assay). For investigating the involvement of LC-SC in noradrenergic system, DSP-4 was used as an injection bilaterally one week before glutamate. Findings: Microinjection of glutamate significantly increased the plasma level of FSH in comparison to saline in control group. Pretreatment with DSP-4 significantly decreased the plasma level of FSH before glutamate injection. Conclusion: The results indicated that LC-SC in adult rats is one of the major sites affected by EAAs on FSH secretion by noradrenergic neurons.
format	article
author	S Shahabi AA Moghadam Nia
author_facet	S Shahabi AA Moghadam Nia
author_sort	S Shahabi
title	Role of central noradrenergic system on FSH secretion induced by excitatory Amino acids
title_short	Role of central noradrenergic system on FSH secretion induced by excitatory Amino acids
title_full	Role of central noradrenergic system on FSH secretion induced by excitatory Amino acids
title_fullStr	Role of central noradrenergic system on FSH secretion induced by excitatory Amino acids
title_full_unstemmed	Role of central noradrenergic system on FSH secretion induced by excitatory Amino acids
title_sort	role of central noradrenergic system on fsh secretion induced by excitatory amino acids
publisher	Babol University of Medical Sciences
publishDate	2001
url	https://doaj.org/article/ff11b5f5a9e34b21969a1911ddd78f3d
work_keys_str_mv	AT sshahabi roleofcentralnoradrenergicsystemonfshsecretioninducedbyexcitatoryaminoacids AT aamoghadamnia roleofcentralnoradrenergicsystemonfshsecretioninducedbyexcitatoryaminoacids
_version_	1718440158016045056

Role of central noradrenergic system on FSH secretion induced by excitatory Amino acids

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