Hydroxyapatite/nifuroxazide conjugate: Characterization, drug release and antimicrobial activity

Synthetic hydroxyapatite (Ca10(PO4)6(OH)2, HAp) is very similar to the inorganic part of the bones and teeth of mammals. It is a well-known biomaterial with good biocompatibility, osteoconductivity and bioactivity. Nifuroxazide (C12H9N3O5, NFX) is a broad-spectrum antibacterial drug and poorly solub...

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Autores principales:	Radovanović Željko, Mihajlovski Katarina, Radovanović Lidija, Janaćković Đorđe, Petrović Rada
Formato:	article
Lenguaje:	EN
Publicado:	Serbian Chemical Society 2021
Materias:	biomaterials nanomaterials drug delivery antimicrobial properties Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/ff13d54332ae4d6fb01c806b89adf6da
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spelling	oai:doaj.org-article:ff13d54332ae4d6fb01c806b89adf6da2021-11-22T11:03:40ZHydroxyapatite/nifuroxazide conjugate: Characterization, drug release and antimicrobial activity0352-51391820-742110.2298/JSC210420040Rhttps://doaj.org/article/ff13d54332ae4d6fb01c806b89adf6da2021-01-01T00:00:00Zhttp://www.doiserbia.nb.rs/img/doi/0352-5139/2021/0352-51392100040R.pdfhttps://doaj.org/toc/0352-5139https://doaj.org/toc/1820-7421Synthetic hydroxyapatite (Ca10(PO4)6(OH)2, HAp) is very similar to the inorganic part of the bones and teeth of mammals. It is a well-known biomaterial with good biocompatibility, osteoconductivity and bioactivity. Nifuroxazide (C12H9N3O5, NFX) is a broad-spectrum antibacterial drug and poorly soluble in water. In order to increase the solubility of NFX, nano-sized HAp powder and raw NFX drug were mixed giving, as a result, a HAp/NFX conjugate. Characterization of the raw materials and the obtained conjugate confirmed the integration of NFX on the HAp surface. An in vitro study of drug release in simulated stomach acid and intestinal fluid showed a much faster release of NFX from HAp surface than those of the raw drug. The HAp/NFX conjugate showed excellent inhibitory effects against Gram-positive bacterium Staphylococcus aureus, Gram-negative bacterium Escherichia coli and yeast Candida albicans, proving the nano-sized HAp powder as a promising drug carrier.Radovanović ŽeljkoMihajlovski KatarinaRadovanović LidijaJanaćković ĐorđePetrović RadaSerbian Chemical Society articlebiomaterialsnanomaterialsdrug deliveryantimicrobial propertiesChemistryQD1-999ENJournal of the Serbian Chemical Society, Vol 86, Iss 11, Pp 1103-1112 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biomaterials nanomaterials drug delivery antimicrobial properties Chemistry QD1-999
spellingShingle	biomaterials nanomaterials drug delivery antimicrobial properties Chemistry QD1-999 Radovanović Željko Mihajlovski Katarina Radovanović Lidija Janaćković Đorđe Petrović Rada Hydroxyapatite/nifuroxazide conjugate: Characterization, drug release and antimicrobial activity
description	Synthetic hydroxyapatite (Ca10(PO4)6(OH)2, HAp) is very similar to the inorganic part of the bones and teeth of mammals. It is a well-known biomaterial with good biocompatibility, osteoconductivity and bioactivity. Nifuroxazide (C12H9N3O5, NFX) is a broad-spectrum antibacterial drug and poorly soluble in water. In order to increase the solubility of NFX, nano-sized HAp powder and raw NFX drug were mixed giving, as a result, a HAp/NFX conjugate. Characterization of the raw materials and the obtained conjugate confirmed the integration of NFX on the HAp surface. An in vitro study of drug release in simulated stomach acid and intestinal fluid showed a much faster release of NFX from HAp surface than those of the raw drug. The HAp/NFX conjugate showed excellent inhibitory effects against Gram-positive bacterium Staphylococcus aureus, Gram-negative bacterium Escherichia coli and yeast Candida albicans, proving the nano-sized HAp powder as a promising drug carrier.
format	article
author	Radovanović Željko Mihajlovski Katarina Radovanović Lidija Janaćković Đorđe Petrović Rada
author_facet	Radovanović Željko Mihajlovski Katarina Radovanović Lidija Janaćković Đorđe Petrović Rada
author_sort	Radovanović Željko
title	Hydroxyapatite/nifuroxazide conjugate: Characterization, drug release and antimicrobial activity
title_short	Hydroxyapatite/nifuroxazide conjugate: Characterization, drug release and antimicrobial activity
title_full	Hydroxyapatite/nifuroxazide conjugate: Characterization, drug release and antimicrobial activity
title_fullStr	Hydroxyapatite/nifuroxazide conjugate: Characterization, drug release and antimicrobial activity
title_full_unstemmed	Hydroxyapatite/nifuroxazide conjugate: Characterization, drug release and antimicrobial activity
title_sort	hydroxyapatite/nifuroxazide conjugate: characterization, drug release and antimicrobial activity
publisher	Serbian Chemical Society
publishDate	2021
url	https://doaj.org/article/ff13d54332ae4d6fb01c806b89adf6da
work_keys_str_mv	AT radovanoviczeljko hydroxyapatitenifuroxazideconjugatecharacterizationdrugreleaseandantimicrobialactivity AT mihajlovskikatarina hydroxyapatitenifuroxazideconjugatecharacterizationdrugreleaseandantimicrobialactivity AT radovanoviclidija hydroxyapatitenifuroxazideconjugatecharacterizationdrugreleaseandantimicrobialactivity AT janackovicđorđe hydroxyapatitenifuroxazideconjugatecharacterizationdrugreleaseandantimicrobialactivity AT petrovicrada hydroxyapatitenifuroxazideconjugatecharacterizationdrugreleaseandantimicrobialactivity
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Hydroxyapatite/nifuroxazide conjugate: Characterization, drug release and antimicrobial activity

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