Correlation between sarcopenia and nailfold microcirculation, serum 25-hydroxycholecalciferol (vitamin D3) and IL-17 levels in female patients with rheumatoid arthritis

Aims. To investigate the correlation between sarcopenia and nailfold microcirculation and serum 25-hydroxycholecalciferol [25 (OH) D3] (instead of 25-hydroxyvitamin D) and IL-17 levels in female rheumatoid arthritis (RA) patients. Methods. 130 female rheumatoid arthritis (RA) patients and 80 healthy...

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Autores principales:	Lei Zhang, Dongmei Mao, Qi Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Palacký University Olomouc, Faculty of Medicine and Dentistry 2021
Materias:	sarcopenia arthritis rheumatoid arthritis nailfold microcirculation 25-hydroxycholecalciferol interleukin 17 correlation study Medicine R
Acceso en línea:	https://doaj.org/article/ff177584236a49479048fcb74647746d
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spelling	oai:doaj.org-article:ff177584236a49479048fcb74647746d2021-11-29T08:47:12ZCorrelation between sarcopenia and nailfold microcirculation, serum 25-hydroxycholecalciferol (vitamin D3) and IL-17 levels in female patients with rheumatoid arthritis1213-81181804-752110.5507/bp.2020.036https://doaj.org/article/ff177584236a49479048fcb74647746d2021-09-01T00:00:00Zhttps://biomed.papers.upol.cz/artkey/bio-202103-0005_correlation-between-sarcopenia-and-nailfold-microcirculation-serum-25-hydroxycholecalciferol-vitamin-d3-and.phphttps://doaj.org/toc/1213-8118https://doaj.org/toc/1804-7521Aims. To investigate the correlation between sarcopenia and nailfold microcirculation and serum 25-hydroxycholecalciferol [25 (OH) D3] (instead of 25-hydroxyvitamin D) and IL-17 levels in female rheumatoid arthritis (RA) patients. Methods. 130 female rheumatoid arthritis (RA) patients and 80 healthy controls were tested. Nailfold capillaroscopic scores (NFCS) were measured. Bioimpedance analysis (BIA) was used to measure skeletal muscle mass. Enzyme-linked immunosorbant assay (ELISA) was used to detect the levels of IL-17, IL-6 and TNF-α. Serum 25 (OH) D3 concentration was determined by photochemical immunoassay. The correlation was analyzed by Pearson's correlation, and the influencing factors were analyzed by binary logistic regression. Results. (1) Compared with the control group, NFCS and serum IL-17 levels were higher in the RA group, while the serum 25 (OH) D3 and skeletal mass index (SMI) were lower. (2) Pearson correlation analysis found: SMI was positively correlated with 25 (OH) D3 (r=0.515, P<0.001), SMI was negatively correlated with IL-17 (r=-0.468, P<0.001), SMI was negatively correlated with NFS (r = -0.229, P=0.009); (3) Logistic regression analysis: serum 25 (OH) D3 was a protective factor for sarcopenia (OR=0.392, P=0.016); IL-17, C-reactive protein, and NFS were risk factors for sarcopenia (OR=1.516, P=0.049; OR=1.469, P=0.045; OR=3.497, P=0.002). Conclusion. Secondary sarcopenia in RA is common and is closely related to microcirculation abnormalities. Increased NFCS is a risk factor for sarcopenia. Decreased serum 25 (OH) D3 levels and increased IL-17 are also risk factors for sarcopenia, but the mechanisms involved in sarcopenia and microcirculation abnormalities need further investigation.Lei ZhangDongmei MaoQi ZhangPalacký University Olomouc, Faculty of Medicine and Dentistryarticlesarcopeniaarthritisrheumatoid arthritisnailfold microcirculation25-hydroxycholecalciferolinterleukin 17correlation studyMedicineRENBiomedical Papers, Vol 165, Iss 3, Pp 264-269 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sarcopenia arthritis rheumatoid arthritis nailfold microcirculation 25-hydroxycholecalciferol interleukin 17 correlation study Medicine R
spellingShingle	sarcopenia arthritis rheumatoid arthritis nailfold microcirculation 25-hydroxycholecalciferol interleukin 17 correlation study Medicine R Lei Zhang Dongmei Mao Qi Zhang Correlation between sarcopenia and nailfold microcirculation, serum 25-hydroxycholecalciferol (vitamin D3) and IL-17 levels in female patients with rheumatoid arthritis
description	Aims. To investigate the correlation between sarcopenia and nailfold microcirculation and serum 25-hydroxycholecalciferol [25 (OH) D3] (instead of 25-hydroxyvitamin D) and IL-17 levels in female rheumatoid arthritis (RA) patients. Methods. 130 female rheumatoid arthritis (RA) patients and 80 healthy controls were tested. Nailfold capillaroscopic scores (NFCS) were measured. Bioimpedance analysis (BIA) was used to measure skeletal muscle mass. Enzyme-linked immunosorbant assay (ELISA) was used to detect the levels of IL-17, IL-6 and TNF-α. Serum 25 (OH) D3 concentration was determined by photochemical immunoassay. The correlation was analyzed by Pearson's correlation, and the influencing factors were analyzed by binary logistic regression. Results. (1) Compared with the control group, NFCS and serum IL-17 levels were higher in the RA group, while the serum 25 (OH) D3 and skeletal mass index (SMI) were lower. (2) Pearson correlation analysis found: SMI was positively correlated with 25 (OH) D3 (r=0.515, P<0.001), SMI was negatively correlated with IL-17 (r=-0.468, P<0.001), SMI was negatively correlated with NFS (r = -0.229, P=0.009); (3) Logistic regression analysis: serum 25 (OH) D3 was a protective factor for sarcopenia (OR=0.392, P=0.016); IL-17, C-reactive protein, and NFS were risk factors for sarcopenia (OR=1.516, P=0.049; OR=1.469, P=0.045; OR=3.497, P=0.002). Conclusion. Secondary sarcopenia in RA is common and is closely related to microcirculation abnormalities. Increased NFCS is a risk factor for sarcopenia. Decreased serum 25 (OH) D3 levels and increased IL-17 are also risk factors for sarcopenia, but the mechanisms involved in sarcopenia and microcirculation abnormalities need further investigation.
format	article
author	Lei Zhang Dongmei Mao Qi Zhang
author_facet	Lei Zhang Dongmei Mao Qi Zhang
author_sort	Lei Zhang
title	Correlation between sarcopenia and nailfold microcirculation, serum 25-hydroxycholecalciferol (vitamin D3) and IL-17 levels in female patients with rheumatoid arthritis
title_short	Correlation between sarcopenia and nailfold microcirculation, serum 25-hydroxycholecalciferol (vitamin D3) and IL-17 levels in female patients with rheumatoid arthritis
title_full	Correlation between sarcopenia and nailfold microcirculation, serum 25-hydroxycholecalciferol (vitamin D3) and IL-17 levels in female patients with rheumatoid arthritis
title_fullStr	Correlation between sarcopenia and nailfold microcirculation, serum 25-hydroxycholecalciferol (vitamin D3) and IL-17 levels in female patients with rheumatoid arthritis
title_full_unstemmed	Correlation between sarcopenia and nailfold microcirculation, serum 25-hydroxycholecalciferol (vitamin D3) and IL-17 levels in female patients with rheumatoid arthritis
title_sort	correlation between sarcopenia and nailfold microcirculation, serum 25-hydroxycholecalciferol (vitamin d3) and il-17 levels in female patients with rheumatoid arthritis
publisher	Palacký University Olomouc, Faculty of Medicine and Dentistry
publishDate	2021
url	https://doaj.org/article/ff177584236a49479048fcb74647746d
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Correlation between sarcopenia and nailfold microcirculation, serum 25-hydroxycholecalciferol (vitamin D3) and IL-17 levels in female patients with rheumatoid arthritis

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