The importance of fasciculation and elongation protein zeta-1 in neural circuit establishment and neurological disorders

The human brain contains an estimated 100 billion neurons that must be systematically organized into functional neural circuits for it to function properly. These circuits range from short-range local signaling networks between neighboring neurons to long-range networks formed between various brain...

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Autores principales:	Rafhanah Banu Bte Abdul Razar, Yinghua Qu, Saravanan Gunaseelan, John Jia En Chua
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2022
Materias:	fasciculation and elongation protein zeta-1; neurological disorder; neuronal development; neuronal differentiation; neuronal networks; synapse formation; synaptic function Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/ff187ed575b24280a73ef6f6a62b3a80
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spelling	oai:doaj.org-article:ff187ed575b24280a73ef6f6a62b3a802021-11-19T12:16:44ZThe importance of fasciculation and elongation protein zeta-1 in neural circuit establishment and neurological disorders1673-537410.4103/1673-5374.327327https://doaj.org/article/ff187ed575b24280a73ef6f6a62b3a802022-01-01T00:00:00Zhttp://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=6;spage=1165;epage=1171;aulast=Razarhttps://doaj.org/toc/1673-5374The human brain contains an estimated 100 billion neurons that must be systematically organized into functional neural circuits for it to function properly. These circuits range from short-range local signaling networks between neighboring neurons to long-range networks formed between various brain regions. Compelling converging evidence indicates that alterations in neural circuits arising from abnormalities during early neuronal development or neurodegeneration contribute significantly to the etiology of neurological disorders. Supporting this notion, efforts to identify genetic causes of these disorders have uncovered an over-representation of genes encoding proteins involved in the processes of neuronal differentiation, maturation, synaptogenesis and synaptic function. Fasciculation and elongation protein zeta-1, a Kinesin-1 adapter, has emerged as a key central player involved in many of these processes. Fasciculation and elongation protein zeta-1-dependent transport of synaptic cargoes and mitochondria is essential for neuronal development and synapse establishment. Furthermore, it acts downstream of guidance cue pathways to regulate axo-dendritic development. Significantly, perturbing its function causes abnormalities in neuronal development and synapse formation both in the brain as well as the peripheral nervous system. Mutations and deletions of the fasciculation and elongation protein zeta-1 gene are linked to neurodevelopmental disorders. Moreover, altered phosphorylation of the protein contributes to neurodegenerative disorders. Together, these findings strongly implicate the importance of fasciculation and elongation protein zeta-1 in the establishment of neuronal circuits and its maintenance.Rafhanah Banu Bte Abdul RazarYinghua QuSaravanan GunaseelanJohn Jia En ChuaWolters Kluwer Medknow Publicationsarticlefasciculation and elongation protein zeta-1; neurological disorder; neuronal development; neuronal differentiation; neuronal networks; synapse formation; synaptic functionNeurology. Diseases of the nervous systemRC346-429ENNeural Regeneration Research, Vol 17, Iss 6, Pp 1165-1171 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	fasciculation and elongation protein zeta-1; neurological disorder; neuronal development; neuronal differentiation; neuronal networks; synapse formation; synaptic function Neurology. Diseases of the nervous system RC346-429
spellingShingle	fasciculation and elongation protein zeta-1; neurological disorder; neuronal development; neuronal differentiation; neuronal networks; synapse formation; synaptic function Neurology. Diseases of the nervous system RC346-429 Rafhanah Banu Bte Abdul Razar Yinghua Qu Saravanan Gunaseelan John Jia En Chua The importance of fasciculation and elongation protein zeta-1 in neural circuit establishment and neurological disorders
description	The human brain contains an estimated 100 billion neurons that must be systematically organized into functional neural circuits for it to function properly. These circuits range from short-range local signaling networks between neighboring neurons to long-range networks formed between various brain regions. Compelling converging evidence indicates that alterations in neural circuits arising from abnormalities during early neuronal development or neurodegeneration contribute significantly to the etiology of neurological disorders. Supporting this notion, efforts to identify genetic causes of these disorders have uncovered an over-representation of genes encoding proteins involved in the processes of neuronal differentiation, maturation, synaptogenesis and synaptic function. Fasciculation and elongation protein zeta-1, a Kinesin-1 adapter, has emerged as a key central player involved in many of these processes. Fasciculation and elongation protein zeta-1-dependent transport of synaptic cargoes and mitochondria is essential for neuronal development and synapse establishment. Furthermore, it acts downstream of guidance cue pathways to regulate axo-dendritic development. Significantly, perturbing its function causes abnormalities in neuronal development and synapse formation both in the brain as well as the peripheral nervous system. Mutations and deletions of the fasciculation and elongation protein zeta-1 gene are linked to neurodevelopmental disorders. Moreover, altered phosphorylation of the protein contributes to neurodegenerative disorders. Together, these findings strongly implicate the importance of fasciculation and elongation protein zeta-1 in the establishment of neuronal circuits and its maintenance.
format	article
author	Rafhanah Banu Bte Abdul Razar Yinghua Qu Saravanan Gunaseelan John Jia En Chua
author_facet	Rafhanah Banu Bte Abdul Razar Yinghua Qu Saravanan Gunaseelan John Jia En Chua
author_sort	Rafhanah Banu Bte Abdul Razar
title	The importance of fasciculation and elongation protein zeta-1 in neural circuit establishment and neurological disorders
title_short	The importance of fasciculation and elongation protein zeta-1 in neural circuit establishment and neurological disorders
title_full	The importance of fasciculation and elongation protein zeta-1 in neural circuit establishment and neurological disorders
title_fullStr	The importance of fasciculation and elongation protein zeta-1 in neural circuit establishment and neurological disorders
title_full_unstemmed	The importance of fasciculation and elongation protein zeta-1 in neural circuit establishment and neurological disorders
title_sort	importance of fasciculation and elongation protein zeta-1 in neural circuit establishment and neurological disorders
publisher	Wolters Kluwer Medknow Publications
publishDate	2022
url	https://doaj.org/article/ff187ed575b24280a73ef6f6a62b3a80
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The importance of fasciculation and elongation protein zeta-1 in neural circuit establishment and neurological disorders

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