Golgi organization is regulated by proteasomal degradation
Correct Golgi assembly is important to cellular homeostasis but regulation of its structure under stress remains unclear. Here, the authors identify stress-induced degradation of GM130 by Golgi-localized 26S proteasomes, leading to Golgi dispersal.
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Nature Portfolio
2020
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oai:doaj.org-article:ff1a3445dde44826a238fff8d76ba3652021-12-02T14:40:50ZGolgi organization is regulated by proteasomal degradation10.1038/s41467-019-14038-92041-1723https://doaj.org/article/ff1a3445dde44826a238fff8d76ba3652020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14038-9https://doaj.org/toc/2041-1723Correct Golgi assembly is important to cellular homeostasis but regulation of its structure under stress remains unclear. Here, the authors identify stress-induced degradation of GM130 by Golgi-localized 26S proteasomes, leading to Golgi dispersal.Avital Eisenberg-LernerRon BenyairNoa HizkiahouNeta NudelRoey MaorMatthias P. KramerMerav D. ShmueliInbal ZigdonMarina Cherniavsky LevAdi UlmanJitka Yehudith SagivMolly DayanBareket DassaMercedes RosenwaldIdit ShacharJie LiYanzhuang WangNili DezorellaSuman KhanZiv PoratEyal ShimoniOri AvinoamYifat MerblNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Avital Eisenberg-Lerner Ron Benyair Noa Hizkiahou Neta Nudel Roey Maor Matthias P. Kramer Merav D. Shmueli Inbal Zigdon Marina Cherniavsky Lev Adi Ulman Jitka Yehudith Sagiv Molly Dayan Bareket Dassa Mercedes Rosenwald Idit Shachar Jie Li Yanzhuang Wang Nili Dezorella Suman Khan Ziv Porat Eyal Shimoni Ori Avinoam Yifat Merbl Golgi organization is regulated by proteasomal degradation |
| description |
Correct Golgi assembly is important to cellular homeostasis but regulation of its structure under stress remains unclear. Here, the authors identify stress-induced degradation of GM130 by Golgi-localized 26S proteasomes, leading to Golgi dispersal. |
| format |
article |
| author |
Avital Eisenberg-Lerner Ron Benyair Noa Hizkiahou Neta Nudel Roey Maor Matthias P. Kramer Merav D. Shmueli Inbal Zigdon Marina Cherniavsky Lev Adi Ulman Jitka Yehudith Sagiv Molly Dayan Bareket Dassa Mercedes Rosenwald Idit Shachar Jie Li Yanzhuang Wang Nili Dezorella Suman Khan Ziv Porat Eyal Shimoni Ori Avinoam Yifat Merbl |
| author_facet |
Avital Eisenberg-Lerner Ron Benyair Noa Hizkiahou Neta Nudel Roey Maor Matthias P. Kramer Merav D. Shmueli Inbal Zigdon Marina Cherniavsky Lev Adi Ulman Jitka Yehudith Sagiv Molly Dayan Bareket Dassa Mercedes Rosenwald Idit Shachar Jie Li Yanzhuang Wang Nili Dezorella Suman Khan Ziv Porat Eyal Shimoni Ori Avinoam Yifat Merbl |
| author_sort |
Avital Eisenberg-Lerner |
| title |
Golgi organization is regulated by proteasomal degradation |
| title_short |
Golgi organization is regulated by proteasomal degradation |
| title_full |
Golgi organization is regulated by proteasomal degradation |
| title_fullStr |
Golgi organization is regulated by proteasomal degradation |
| title_full_unstemmed |
Golgi organization is regulated by proteasomal degradation |
| title_sort |
golgi organization is regulated by proteasomal degradation |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/ff1a3445dde44826a238fff8d76ba365 |
| work_keys_str_mv |
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1718390150641221632 |