DISTINCTIVE FEATURES OF HORMONAL STATUS IN MALE ADOLESCENTS WITH ESSENTIAL HYPERTENSION AND OBSTRUCTIVE SLEEP APNEA

Background. It is known that obstructive sleep apnea (OSA) has been closely linked to essential hypertension (EH) and is considered as an important stressor. The hypothalamic-pituitary-adrenal axis (HPA) is a major component involved in stress response. However, the response of HPA axis to OSA effec...

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Autores principales:	O. N. Berdina, L. F. Sholokhov, L. V. Rychkova, I. M. Madaeva
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2017
Materias:	adolescents hypertension hormones sleep apnea Science Q
Acceso en línea:	https://doaj.org/article/ff1ed3f523d147a1a0c61f4ecb2a7886
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spelling	oai:doaj.org-article:ff1ed3f523d147a1a0c61f4ecb2a78862021-11-23T06:14:38ZDISTINCTIVE FEATURES OF HORMONAL STATUS IN MALE ADOLESCENTS WITH ESSENTIAL HYPERTENSION AND OBSTRUCTIVE SLEEP APNEA2541-94202587-959610.12737/article_59fad5149bcb24.36563455https://doaj.org/article/ff1ed3f523d147a1a0c61f4ecb2a78862017-07-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/412https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Background. It is known that obstructive sleep apnea (OSA) has been closely linked to essential hypertension (EH) and is considered as an important stressor. The hypothalamic-pituitary-adrenal axis (HPA) is a major component involved in stress response. However, the response of HPA axis to OSA effects may be variable. Aim: to estimate hormonal status in OSA and non-OSA adolescents with EH. Methods. We examined 38 male adolescents with EH (18 OSA patients - group A, 20 non-OSA patients - group B) aged 14-17 years. OSA was verified by polysomnography applying system GRASS-TeLeFACTOR Twin PSG (Comet, USA). EH was diagnosed with 24-h ambulatory blood pressure monitoring using monitor Oscar 2 for OXFORD Medilog Prima. Hormonal status, including thyroid-stimulating hormone (TSH), prolactin (PRL) and cortisol, were routinely collected using an automatic analyzer «Cobos ELL» (USA) and test-system «Alcor-bio» (Russia). All differences were considered significant at p < 0.05. Results. There were statistically significant differences in morning serum cortisol level of OSA adolescents (745.8 ± 6.4 nmol/L versus 493.2 ± 3.2 nmol/L in non-OSA participants; р < 0.05). Morning serum PRL and TSH levels in the both groups no statistically significant differences, but there is a trend towards its increasing in OSA adolescents with EH (482.8 ± 4.2 mME/L in the group A and 442.2 ± 4.1 mME/L in the group B, and 1.95 ± 0.9 mkME/ml versus 1.5 ± 0.2 mkME/ml, respectively, р < 0.05). Conclusion. The results of this study indicate for chronic stress if OSA in adolescents with EH is present. This is due to the influence of sleep fragmentation and intermittent hypoxia on HPA axis with compensatory stress-related hormones release.O. N. BerdinaL. F. SholokhovL. V. RychkovaI. M. MadaevaScientific Сentre for Family Health and Human Reproduction Problemsarticleadolescentshypertensionhormonessleep apneaScienceQRUActa Biomedica Scientifica, Vol 2, Iss 4, Pp 53-57 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	adolescents hypertension hormones sleep apnea Science Q
spellingShingle	adolescents hypertension hormones sleep apnea Science Q O. N. Berdina L. F. Sholokhov L. V. Rychkova I. M. Madaeva DISTINCTIVE FEATURES OF HORMONAL STATUS IN MALE ADOLESCENTS WITH ESSENTIAL HYPERTENSION AND OBSTRUCTIVE SLEEP APNEA
description	Background. It is known that obstructive sleep apnea (OSA) has been closely linked to essential hypertension (EH) and is considered as an important stressor. The hypothalamic-pituitary-adrenal axis (HPA) is a major component involved in stress response. However, the response of HPA axis to OSA effects may be variable. Aim: to estimate hormonal status in OSA and non-OSA adolescents with EH. Methods. We examined 38 male adolescents with EH (18 OSA patients - group A, 20 non-OSA patients - group B) aged 14-17 years. OSA was verified by polysomnography applying system GRASS-TeLeFACTOR Twin PSG (Comet, USA). EH was diagnosed with 24-h ambulatory blood pressure monitoring using monitor Oscar 2 for OXFORD Medilog Prima. Hormonal status, including thyroid-stimulating hormone (TSH), prolactin (PRL) and cortisol, were routinely collected using an automatic analyzer «Cobos ELL» (USA) and test-system «Alcor-bio» (Russia). All differences were considered significant at p < 0.05. Results. There were statistically significant differences in morning serum cortisol level of OSA adolescents (745.8 ± 6.4 nmol/L versus 493.2 ± 3.2 nmol/L in non-OSA participants; р < 0.05). Morning serum PRL and TSH levels in the both groups no statistically significant differences, but there is a trend towards its increasing in OSA adolescents with EH (482.8 ± 4.2 mME/L in the group A and 442.2 ± 4.1 mME/L in the group B, and 1.95 ± 0.9 mkME/ml versus 1.5 ± 0.2 mkME/ml, respectively, р < 0.05). Conclusion. The results of this study indicate for chronic stress if OSA in adolescents with EH is present. This is due to the influence of sleep fragmentation and intermittent hypoxia on HPA axis with compensatory stress-related hormones release.
format	article
author	O. N. Berdina L. F. Sholokhov L. V. Rychkova I. M. Madaeva
author_facet	O. N. Berdina L. F. Sholokhov L. V. Rychkova I. M. Madaeva
author_sort	O. N. Berdina
title	DISTINCTIVE FEATURES OF HORMONAL STATUS IN MALE ADOLESCENTS WITH ESSENTIAL HYPERTENSION AND OBSTRUCTIVE SLEEP APNEA
title_short	DISTINCTIVE FEATURES OF HORMONAL STATUS IN MALE ADOLESCENTS WITH ESSENTIAL HYPERTENSION AND OBSTRUCTIVE SLEEP APNEA
title_full	DISTINCTIVE FEATURES OF HORMONAL STATUS IN MALE ADOLESCENTS WITH ESSENTIAL HYPERTENSION AND OBSTRUCTIVE SLEEP APNEA
title_fullStr	DISTINCTIVE FEATURES OF HORMONAL STATUS IN MALE ADOLESCENTS WITH ESSENTIAL HYPERTENSION AND OBSTRUCTIVE SLEEP APNEA
title_full_unstemmed	DISTINCTIVE FEATURES OF HORMONAL STATUS IN MALE ADOLESCENTS WITH ESSENTIAL HYPERTENSION AND OBSTRUCTIVE SLEEP APNEA
title_sort	distinctive features of hormonal status in male adolescents with essential hypertension and obstructive sleep apnea
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2017
url	https://doaj.org/article/ff1ed3f523d147a1a0c61f4ecb2a7886
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DISTINCTIVE FEATURES OF HORMONAL STATUS IN MALE ADOLESCENTS WITH ESSENTIAL HYPERTENSION AND OBSTRUCTIVE SLEEP APNEA

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