A pilot study of cystic fibrosis exacerbation response phenotypes reveals contrasting serum and sputum iron trends

Abstract The cystic fibrosis (CF) community seeks to explain heterogeneous outcomes of pulmonary exacerbation (PEX) treatment. Serum and sputum inflammatory mediators may identify people with CF (PwCF) at risk for suboptimal responses. However, lack of an established association between response phe...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Alex H. Gifford, Deepika Polineni, Jianghua He, Jessica L. D’Amico, Dana B. Dorman, Molly A. Williams, Amanda B. Nymon, Akshu Balwan, Theodore Budden, Jonathan B. Zuckerman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ff206a3200c9407398acb1339e5aa7c6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ff206a3200c9407398acb1339e5aa7c6
record_format	dspace
spelling	oai:doaj.org-article:ff206a3200c9407398acb1339e5aa7c62021-12-02T15:53:59ZA pilot study of cystic fibrosis exacerbation response phenotypes reveals contrasting serum and sputum iron trends10.1038/s41598-021-84041-y2045-2322https://doaj.org/article/ff206a3200c9407398acb1339e5aa7c62021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84041-yhttps://doaj.org/toc/2045-2322Abstract The cystic fibrosis (CF) community seeks to explain heterogeneous outcomes of pulmonary exacerbation (PEX) treatment. Serum and sputum inflammatory mediators may identify people with CF (PwCF) at risk for suboptimal responses. However, lack of an established association between response phenotypes and these mediators limits clinical application. In this pilot study, we prospectively characterized treatment response phenotypes by assessing health-related quality-of-life (HRQoL) during PEX. We also measured lung function and iron-related biochemical parameters in serum and sputum. We classified subjects as sustained symptom-responders (SRs) or non-sustained symptom-responders (NSRs) based on the absence or presence, respectively, of worsened symptom scores after initial improvement. We used linear mixed models (LMMs) to determine whether trends in lung function, hematologic, serum, and sputum indices of inflammation differed between response cohorts. In 20 PwCF, we identified 10 SRs and 10 NSRs with no significant differences in lung function at PEX onset and treatment durations. SRs had better model-predicted trends in lung function than NSRs during PEX. Non-linear trends in serum and sputum iron levels significantly differed between SRs and NSRs. In adults with cystic fibrosis, PEX treatment response phenotypes may be correlated with distinctive trends in serum and sputum iron concentrations.Alex H. GiffordDeepika PolineniJianghua HeJessica L. D’AmicoDana B. DormanMolly A. WilliamsAmanda B. NymonAkshu BalwanTheodore BuddenJonathan B. ZuckermanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alex H. Gifford Deepika Polineni Jianghua He Jessica L. D’Amico Dana B. Dorman Molly A. Williams Amanda B. Nymon Akshu Balwan Theodore Budden Jonathan B. Zuckerman A pilot study of cystic fibrosis exacerbation response phenotypes reveals contrasting serum and sputum iron trends
description	Abstract The cystic fibrosis (CF) community seeks to explain heterogeneous outcomes of pulmonary exacerbation (PEX) treatment. Serum and sputum inflammatory mediators may identify people with CF (PwCF) at risk for suboptimal responses. However, lack of an established association between response phenotypes and these mediators limits clinical application. In this pilot study, we prospectively characterized treatment response phenotypes by assessing health-related quality-of-life (HRQoL) during PEX. We also measured lung function and iron-related biochemical parameters in serum and sputum. We classified subjects as sustained symptom-responders (SRs) or non-sustained symptom-responders (NSRs) based on the absence or presence, respectively, of worsened symptom scores after initial improvement. We used linear mixed models (LMMs) to determine whether trends in lung function, hematologic, serum, and sputum indices of inflammation differed between response cohorts. In 20 PwCF, we identified 10 SRs and 10 NSRs with no significant differences in lung function at PEX onset and treatment durations. SRs had better model-predicted trends in lung function than NSRs during PEX. Non-linear trends in serum and sputum iron levels significantly differed between SRs and NSRs. In adults with cystic fibrosis, PEX treatment response phenotypes may be correlated with distinctive trends in serum and sputum iron concentrations.
format	article
author	Alex H. Gifford Deepika Polineni Jianghua He Jessica L. D’Amico Dana B. Dorman Molly A. Williams Amanda B. Nymon Akshu Balwan Theodore Budden Jonathan B. Zuckerman
author_facet	Alex H. Gifford Deepika Polineni Jianghua He Jessica L. D’Amico Dana B. Dorman Molly A. Williams Amanda B. Nymon Akshu Balwan Theodore Budden Jonathan B. Zuckerman
author_sort	Alex H. Gifford
title	A pilot study of cystic fibrosis exacerbation response phenotypes reveals contrasting serum and sputum iron trends
title_short	A pilot study of cystic fibrosis exacerbation response phenotypes reveals contrasting serum and sputum iron trends
title_full	A pilot study of cystic fibrosis exacerbation response phenotypes reveals contrasting serum and sputum iron trends
title_fullStr	A pilot study of cystic fibrosis exacerbation response phenotypes reveals contrasting serum and sputum iron trends
title_full_unstemmed	A pilot study of cystic fibrosis exacerbation response phenotypes reveals contrasting serum and sputum iron trends
title_sort	pilot study of cystic fibrosis exacerbation response phenotypes reveals contrasting serum and sputum iron trends
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ff206a3200c9407398acb1339e5aa7c6
work_keys_str_mv	AT alexhgifford apilotstudyofcysticfibrosisexacerbationresponsephenotypesrevealscontrastingserumandsputumirontrends AT deepikapolineni apilotstudyofcysticfibrosisexacerbationresponsephenotypesrevealscontrastingserumandsputumirontrends AT jianghuahe apilotstudyofcysticfibrosisexacerbationresponsephenotypesrevealscontrastingserumandsputumirontrends AT jessicaldamico apilotstudyofcysticfibrosisexacerbationresponsephenotypesrevealscontrastingserumandsputumirontrends AT danabdorman apilotstudyofcysticfibrosisexacerbationresponsephenotypesrevealscontrastingserumandsputumirontrends AT mollyawilliams apilotstudyofcysticfibrosisexacerbationresponsephenotypesrevealscontrastingserumandsputumirontrends AT amandabnymon apilotstudyofcysticfibrosisexacerbationresponsephenotypesrevealscontrastingserumandsputumirontrends AT akshubalwan apilotstudyofcysticfibrosisexacerbationresponsephenotypesrevealscontrastingserumandsputumirontrends AT theodorebudden apilotstudyofcysticfibrosisexacerbationresponsephenotypesrevealscontrastingserumandsputumirontrends AT jonathanbzuckerman apilotstudyofcysticfibrosisexacerbationresponsephenotypesrevealscontrastingserumandsputumirontrends AT alexhgifford pilotstudyofcysticfibrosisexacerbationresponsephenotypesrevealscontrastingserumandsputumirontrends AT deepikapolineni pilotstudyofcysticfibrosisexacerbationresponsephenotypesrevealscontrastingserumandsputumirontrends AT jianghuahe pilotstudyofcysticfibrosisexacerbationresponsephenotypesrevealscontrastingserumandsputumirontrends AT jessicaldamico pilotstudyofcysticfibrosisexacerbationresponsephenotypesrevealscontrastingserumandsputumirontrends AT danabdorman pilotstudyofcysticfibrosisexacerbationresponsephenotypesrevealscontrastingserumandsputumirontrends AT mollyawilliams pilotstudyofcysticfibrosisexacerbationresponsephenotypesrevealscontrastingserumandsputumirontrends AT amandabnymon pilotstudyofcysticfibrosisexacerbationresponsephenotypesrevealscontrastingserumandsputumirontrends AT akshubalwan pilotstudyofcysticfibrosisexacerbationresponsephenotypesrevealscontrastingserumandsputumirontrends AT theodorebudden pilotstudyofcysticfibrosisexacerbationresponsephenotypesrevealscontrastingserumandsputumirontrends AT jonathanbzuckerman pilotstudyofcysticfibrosisexacerbationresponsephenotypesrevealscontrastingserumandsputumirontrends
_version_	1718385489124261888

A pilot study of cystic fibrosis exacerbation response phenotypes reveals contrasting serum and sputum iron trends

Ejemplares similares