The Inflammatory Aspect of Male and Female Pattern Hair Loss

Nadia Peyravian,1 Sapna Deo,1 Sylvia Daunert,1 Joaquin J Jimenez1,2 1Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, USA; 2Dr. Phillip Frost Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicin...

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Autores principales:	Peyravian N, Deo S, Daunert S, Jimenez JJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	hair loss inflammation male pattern baldness female pattern baldness Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/ff21c52805654d0ba0840dd9a07365b6
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spelling	oai:doaj.org-article:ff21c52805654d0ba0840dd9a07365b62021-12-02T12:58:44ZThe Inflammatory Aspect of Male and Female Pattern Hair Loss1178-7031https://doaj.org/article/ff21c52805654d0ba0840dd9a07365b62020-11-01T00:00:00Zhttps://www.dovepress.com/the-inflammatory-aspect-of-male-and-female-pattern-hair-loss-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Nadia Peyravian,1 Sapna Deo,1 Sylvia Daunert,1 Joaquin J Jimenez1,2 1Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, USA; 2Dr. Phillip Frost Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USACorrespondence: Joaquin J JimenezDepartment of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, 1011 NW 15th Street, Miami, FL 33136, USATel +1 305 243 6586Email j.jimenez@med.miami.eduAbstract: Male and female pattern hair loss (MPHL and FPHL, respectively), is the most common cause of hair loss affecting nearly 80 million people in the US, yet treatment options remain limited and lacking. As the need for more effective therapeutics remains unmet, this perspective offers a unique angle by directing attention to the inflammatory aspect of MPHL and FPHL. Evidence and implications of inflammation as a characteristic feature of MPHL and FPHL are highlighted through evaluation of clinical and quantitative data. Comparable results suggest the presence of significant perifollicular inflammatory infiltrates, such as lymphocytes and histiocytes, as well as the involvement of inflammatory genes, such as CASP7 and TNF, in the presentation of MPHL and FPHL. Resurfacing of the inflammatory aspect in MPHL and FPHL pathogenesis will advance future developments in MPHL and FPHL therapeutic options.Keywords: hair loss, inflammation, male pattern baldness, female pattern baldnessPeyravian NDeo SDaunert SJimenez JJDove Medical Pressarticlehair lossinflammationmale pattern baldnessfemale pattern baldnessPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 13, Pp 879-881 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	hair loss inflammation male pattern baldness female pattern baldness Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	hair loss inflammation male pattern baldness female pattern baldness Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Peyravian N Deo S Daunert S Jimenez JJ The Inflammatory Aspect of Male and Female Pattern Hair Loss
description	Nadia Peyravian,1 Sapna Deo,1 Sylvia Daunert,1 Joaquin J Jimenez1,2 1Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, USA; 2Dr. Phillip Frost Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USACorrespondence: Joaquin J JimenezDepartment of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, 1011 NW 15th Street, Miami, FL 33136, USATel +1 305 243 6586Email j.jimenez@med.miami.eduAbstract: Male and female pattern hair loss (MPHL and FPHL, respectively), is the most common cause of hair loss affecting nearly 80 million people in the US, yet treatment options remain limited and lacking. As the need for more effective therapeutics remains unmet, this perspective offers a unique angle by directing attention to the inflammatory aspect of MPHL and FPHL. Evidence and implications of inflammation as a characteristic feature of MPHL and FPHL are highlighted through evaluation of clinical and quantitative data. Comparable results suggest the presence of significant perifollicular inflammatory infiltrates, such as lymphocytes and histiocytes, as well as the involvement of inflammatory genes, such as CASP7 and TNF, in the presentation of MPHL and FPHL. Resurfacing of the inflammatory aspect in MPHL and FPHL pathogenesis will advance future developments in MPHL and FPHL therapeutic options.Keywords: hair loss, inflammation, male pattern baldness, female pattern baldness
format	article
author	Peyravian N Deo S Daunert S Jimenez JJ
author_facet	Peyravian N Deo S Daunert S Jimenez JJ
author_sort	Peyravian N
title	The Inflammatory Aspect of Male and Female Pattern Hair Loss
title_short	The Inflammatory Aspect of Male and Female Pattern Hair Loss
title_full	The Inflammatory Aspect of Male and Female Pattern Hair Loss
title_fullStr	The Inflammatory Aspect of Male and Female Pattern Hair Loss
title_full_unstemmed	The Inflammatory Aspect of Male and Female Pattern Hair Loss
title_sort	inflammatory aspect of male and female pattern hair loss
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/ff21c52805654d0ba0840dd9a07365b6
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The Inflammatory Aspect of Male and Female Pattern Hair Loss

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