One-Step Fabrication of pH-Responsive Membranes and Microcapsules through Interfacial H-Bond Polymer Complexation

Abstract Biocompatible microencapsulation is of widespread interest for the targeted delivery of active species in fields such as pharmaceuticals, cosmetics and agro-chemistry. Capsules obtained by the self-assembly of polymers at interfaces enable the combination of responsiveness to stimuli, bioco...

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Autores principales:	Julien Dupré de Baubigny, Corentin Trégouët, Thomas Salez, Nadège Pantoustier, Patrick Perrin, Mathilde Reyssat, Cécile Monteux
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ff22ad3161f6442297375ea1571a8581
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spelling	oai:doaj.org-article:ff22ad3161f6442297375ea1571a85812021-12-02T12:31:55ZOne-Step Fabrication of pH-Responsive Membranes and Microcapsules through Interfacial H-Bond Polymer Complexation10.1038/s41598-017-01374-32045-2322https://doaj.org/article/ff22ad3161f6442297375ea1571a85812017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01374-3https://doaj.org/toc/2045-2322Abstract Biocompatible microencapsulation is of widespread interest for the targeted delivery of active species in fields such as pharmaceuticals, cosmetics and agro-chemistry. Capsules obtained by the self-assembly of polymers at interfaces enable the combination of responsiveness to stimuli, biocompatibility and scaled up production. Here, we present a one-step method to produce in situ membranes at oil-water interfaces, based on the hydrogen bond complexation of polymers between H-bond acceptor and donor in the oil and aqueous phases, respectively. This robust process is realized through different methods, to obtain capsules of various sizes, from the micrometer scale using microfluidics or rotor-stator emulsification up to the centimeter scale using drop dripping. The polymer layer exhibits unique self-healing and pH-responsive properties. The membrane is viscoelastic at pH = 3, softens as pH is progressively raised, and eventually dissolves above pH = 6 to release the oil phase. This one-step method of preparation paves the way to the production of large quantities of functional capsules.Julien Dupré de BaubignyCorentin TrégouëtThomas SalezNadège PantoustierPatrick PerrinMathilde ReyssatCécile MonteuxNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Julien Dupré de Baubigny Corentin Trégouët Thomas Salez Nadège Pantoustier Patrick Perrin Mathilde Reyssat Cécile Monteux One-Step Fabrication of pH-Responsive Membranes and Microcapsules through Interfacial H-Bond Polymer Complexation
description	Abstract Biocompatible microencapsulation is of widespread interest for the targeted delivery of active species in fields such as pharmaceuticals, cosmetics and agro-chemistry. Capsules obtained by the self-assembly of polymers at interfaces enable the combination of responsiveness to stimuli, biocompatibility and scaled up production. Here, we present a one-step method to produce in situ membranes at oil-water interfaces, based on the hydrogen bond complexation of polymers between H-bond acceptor and donor in the oil and aqueous phases, respectively. This robust process is realized through different methods, to obtain capsules of various sizes, from the micrometer scale using microfluidics or rotor-stator emulsification up to the centimeter scale using drop dripping. The polymer layer exhibits unique self-healing and pH-responsive properties. The membrane is viscoelastic at pH = 3, softens as pH is progressively raised, and eventually dissolves above pH = 6 to release the oil phase. This one-step method of preparation paves the way to the production of large quantities of functional capsules.
format	article
author	Julien Dupré de Baubigny Corentin Trégouët Thomas Salez Nadège Pantoustier Patrick Perrin Mathilde Reyssat Cécile Monteux
author_facet	Julien Dupré de Baubigny Corentin Trégouët Thomas Salez Nadège Pantoustier Patrick Perrin Mathilde Reyssat Cécile Monteux
author_sort	Julien Dupré de Baubigny
title	One-Step Fabrication of pH-Responsive Membranes and Microcapsules through Interfacial H-Bond Polymer Complexation
title_short	One-Step Fabrication of pH-Responsive Membranes and Microcapsules through Interfacial H-Bond Polymer Complexation
title_full	One-Step Fabrication of pH-Responsive Membranes and Microcapsules through Interfacial H-Bond Polymer Complexation
title_fullStr	One-Step Fabrication of pH-Responsive Membranes and Microcapsules through Interfacial H-Bond Polymer Complexation
title_full_unstemmed	One-Step Fabrication of pH-Responsive Membranes and Microcapsules through Interfacial H-Bond Polymer Complexation
title_sort	one-step fabrication of ph-responsive membranes and microcapsules through interfacial h-bond polymer complexation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ff22ad3161f6442297375ea1571a8581
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One-Step Fabrication of pH-Responsive Membranes and Microcapsules through Interfacial H-Bond Polymer Complexation

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