Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development

The gene regulatory networks that coordinate the development of the cardiac and pulmonary systems are essential for terrestrial life but poorly understood. The T-box transcription factor Tbx5 is critical for both pulmonary specification and heart development, but how these activities are mechanistic...

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Autores principales: Scott A Rankin, Jeffrey D Steimle, Xinan H Yang, Ariel B Rydeen, Kunal Agarwal, Praneet Chaturvedi, Kohta Ikegami, Michael J Herriges, Ivan P Moskowitz, Aaron M Zorn
Formato: article
Lenguaje:EN
Publicado: eLife Sciences Publications Ltd 2021
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Acceso en línea:https://doaj.org/article/ff23278fda4f49459f92c86f5c8b7d55
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