Molecular basis of IRGB10 oligomerization and membrane association for pathogen membrane disruption

Ha et al. present a crystal structure of mouse IRGB10, a mouse interferon-inducible GTPase that mediates bacteriolysis in cell autonomous immunity. With further mutagenesis studies, they show that IRGB10 bound to GDP forms an inactive head-to-head dimer, which changes its conformation to activate it...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hyun Ji Ha, Hye Lin Chun, So Yeon Lee, Jae-Hee Jeong, Yeon-Gil Kim, Hyun Ho Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ff265e0c1fcd4646bb457b6220dcd6a4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ff265e0c1fcd4646bb457b6220dcd6a4
record_format	dspace
spelling	oai:doaj.org-article:ff265e0c1fcd4646bb457b6220dcd6a42021-12-02T10:49:10ZMolecular basis of IRGB10 oligomerization and membrane association for pathogen membrane disruption10.1038/s42003-020-01640-72399-3642https://doaj.org/article/ff265e0c1fcd4646bb457b6220dcd6a42021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01640-7https://doaj.org/toc/2399-3642Ha et al. present a crystal structure of mouse IRGB10, a mouse interferon-inducible GTPase that mediates bacteriolysis in cell autonomous immunity. With further mutagenesis studies, they show that IRGB10 bound to GDP forms an inactive head-to-head dimer, which changes its conformation to activate its membrane-binding and disruptive functions.Hyun Ji HaHye Lin ChunSo Yeon LeeJae-Hee JeongYeon-Gil KimHyun Ho ParkNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Hyun Ji Ha Hye Lin Chun So Yeon Lee Jae-Hee Jeong Yeon-Gil Kim Hyun Ho Park Molecular basis of IRGB10 oligomerization and membrane association for pathogen membrane disruption
description	Ha et al. present a crystal structure of mouse IRGB10, a mouse interferon-inducible GTPase that mediates bacteriolysis in cell autonomous immunity. With further mutagenesis studies, they show that IRGB10 bound to GDP forms an inactive head-to-head dimer, which changes its conformation to activate its membrane-binding and disruptive functions.
format	article
author	Hyun Ji Ha Hye Lin Chun So Yeon Lee Jae-Hee Jeong Yeon-Gil Kim Hyun Ho Park
author_facet	Hyun Ji Ha Hye Lin Chun So Yeon Lee Jae-Hee Jeong Yeon-Gil Kim Hyun Ho Park
author_sort	Hyun Ji Ha
title	Molecular basis of IRGB10 oligomerization and membrane association for pathogen membrane disruption
title_short	Molecular basis of IRGB10 oligomerization and membrane association for pathogen membrane disruption
title_full	Molecular basis of IRGB10 oligomerization and membrane association for pathogen membrane disruption
title_fullStr	Molecular basis of IRGB10 oligomerization and membrane association for pathogen membrane disruption
title_full_unstemmed	Molecular basis of IRGB10 oligomerization and membrane association for pathogen membrane disruption
title_sort	molecular basis of irgb10 oligomerization and membrane association for pathogen membrane disruption
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ff265e0c1fcd4646bb457b6220dcd6a4
work_keys_str_mv	AT hyunjiha molecularbasisofirgb10oligomerizationandmembraneassociationforpathogenmembranedisruption AT hyelinchun molecularbasisofirgb10oligomerizationandmembraneassociationforpathogenmembranedisruption AT soyeonlee molecularbasisofirgb10oligomerizationandmembraneassociationforpathogenmembranedisruption AT jaeheejeong molecularbasisofirgb10oligomerizationandmembraneassociationforpathogenmembranedisruption AT yeongilkim molecularbasisofirgb10oligomerizationandmembraneassociationforpathogenmembranedisruption AT hyunhopark molecularbasisofirgb10oligomerizationandmembraneassociationforpathogenmembranedisruption
_version_	1718396626875187200

Molecular basis of IRGB10 oligomerization and membrane association for pathogen membrane disruption

Ejemplares similares