Virulent Bacteria as Inflammatory and Immune Co-Factor in Colon Carcinogenesis: Evidence From Two Monozygotic Patients and Validation in CRC Patient and Healthy Cohorts

Colorectal carcinoma (CRC) is a common disease, the incidence of which is increasing according to Western lifestyle; it remains to have a poor prognosis. Western nutriments are presumed to induce mild inflammation within the colonic mucosa, resulting in the accumulation of DNA alterations in colonoc...

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Autores principales:	Iradj Sobhani, Emma Bergsten, Cecile Charpy, Mathias Chamaillard, Denis Mestivier
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	cancer colon microbiota immune cells virulent bacteria Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/ff295b4b5fd04330924279b5584afca0
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spelling	oai:doaj.org-article:ff295b4b5fd04330924279b5584afca02021-11-04T11:09:24ZVirulent Bacteria as Inflammatory and Immune Co-Factor in Colon Carcinogenesis: Evidence From Two Monozygotic Patients and Validation in CRC Patient and Healthy Cohorts2235-298810.3389/fcimb.2021.749750https://doaj.org/article/ff295b4b5fd04330924279b5584afca02021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcimb.2021.749750/fullhttps://doaj.org/toc/2235-2988Colorectal carcinoma (CRC) is a common disease, the incidence of which is increasing according to Western lifestyle; it remains to have a poor prognosis. Western nutriments are presumed to induce mild inflammation within the colonic mucosa, resulting in the accumulation of DNA alterations in colonocytes through a multistage carcinogenesis process. This suggests that most CRCs are related to the environment. Of interest, fecal microbiota composition has been shown yielding a novel approach regarding how environment changes may impact health and disease. Here, we compare whole shotgun metagenomic gut microbiota of two monozygotic twin sisters, one of whom is suffering from an advance colorectal tumor with a profound disequilibrium of the composition of the gut microbiota due to the overexpression of virulent bacteria such as E. coli, Shigella, and Clostridium species in the colon cancer patient’s feces contrasting with low levels of bacterial species such as Faecalibacterium and Akkermansia usually enriched in the healthy adults’ microbial flora. The disequilibrium in microbiota of the CRC patient’s feces as compared to her monozygotic twin sister is linked to inflammatory and immune cell infiltrates in the patient’s colonic tissue. We speculate on the role of microbiota disequilibrium on the immune-tolerant cell infiltrate within CRCs.Iradj SobhaniIradj SobhaniIradj SobhaniEmma BergstenCecile CharpyMathias ChamaillardDenis MestivierDenis MestivierFrontiers Media S.A.articlecancercolonmicrobiotaimmune cellsvirulent bacteriaMicrobiologyQR1-502ENFrontiers in Cellular and Infection Microbiology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cancer colon microbiota immune cells virulent bacteria Microbiology QR1-502
spellingShingle	cancer colon microbiota immune cells virulent bacteria Microbiology QR1-502 Iradj Sobhani Iradj Sobhani Iradj Sobhani Emma Bergsten Cecile Charpy Mathias Chamaillard Denis Mestivier Denis Mestivier Virulent Bacteria as Inflammatory and Immune Co-Factor in Colon Carcinogenesis: Evidence From Two Monozygotic Patients and Validation in CRC Patient and Healthy Cohorts
description	Colorectal carcinoma (CRC) is a common disease, the incidence of which is increasing according to Western lifestyle; it remains to have a poor prognosis. Western nutriments are presumed to induce mild inflammation within the colonic mucosa, resulting in the accumulation of DNA alterations in colonocytes through a multistage carcinogenesis process. This suggests that most CRCs are related to the environment. Of interest, fecal microbiota composition has been shown yielding a novel approach regarding how environment changes may impact health and disease. Here, we compare whole shotgun metagenomic gut microbiota of two monozygotic twin sisters, one of whom is suffering from an advance colorectal tumor with a profound disequilibrium of the composition of the gut microbiota due to the overexpression of virulent bacteria such as E. coli, Shigella, and Clostridium species in the colon cancer patient’s feces contrasting with low levels of bacterial species such as Faecalibacterium and Akkermansia usually enriched in the healthy adults’ microbial flora. The disequilibrium in microbiota of the CRC patient’s feces as compared to her monozygotic twin sister is linked to inflammatory and immune cell infiltrates in the patient’s colonic tissue. We speculate on the role of microbiota disequilibrium on the immune-tolerant cell infiltrate within CRCs.
format	article
author	Iradj Sobhani Iradj Sobhani Iradj Sobhani Emma Bergsten Cecile Charpy Mathias Chamaillard Denis Mestivier Denis Mestivier
author_facet	Iradj Sobhani Iradj Sobhani Iradj Sobhani Emma Bergsten Cecile Charpy Mathias Chamaillard Denis Mestivier Denis Mestivier
author_sort	Iradj Sobhani
title	Virulent Bacteria as Inflammatory and Immune Co-Factor in Colon Carcinogenesis: Evidence From Two Monozygotic Patients and Validation in CRC Patient and Healthy Cohorts
title_short	Virulent Bacteria as Inflammatory and Immune Co-Factor in Colon Carcinogenesis: Evidence From Two Monozygotic Patients and Validation in CRC Patient and Healthy Cohorts
title_full	Virulent Bacteria as Inflammatory and Immune Co-Factor in Colon Carcinogenesis: Evidence From Two Monozygotic Patients and Validation in CRC Patient and Healthy Cohorts
title_fullStr	Virulent Bacteria as Inflammatory and Immune Co-Factor in Colon Carcinogenesis: Evidence From Two Monozygotic Patients and Validation in CRC Patient and Healthy Cohorts
title_full_unstemmed	Virulent Bacteria as Inflammatory and Immune Co-Factor in Colon Carcinogenesis: Evidence From Two Monozygotic Patients and Validation in CRC Patient and Healthy Cohorts
title_sort	virulent bacteria as inflammatory and immune co-factor in colon carcinogenesis: evidence from two monozygotic patients and validation in crc patient and healthy cohorts
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/ff295b4b5fd04330924279b5584afca0
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Virulent Bacteria as Inflammatory and Immune Co-Factor in Colon Carcinogenesis: Evidence From Two Monozygotic Patients and Validation in CRC Patient and Healthy Cohorts

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