Association of Serum Kynurenine Levels and Neural Networks in Patients with First-Episode, Drug-Naïve Major Depression: A Source-Based Morphometry Study

Association of Serum Kynurenine Levels and Neural Networks in Patients with First-Episode, Drug-Naïve Major Depression: A Source-Based Morphometry Study

Naomichi Okamoto,1 Keita Watanabe,2 LeHoa Ngyuyen,1,3 Atsuko Ikenouchi,1 Taro Kishi,4 Nakao Iwata,4 Shingo Kakeda,5 Yukunori Korogi,6 Reiji Yoshimura1 1Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan; 2Open Innovation Institute, Kyoto University, Kyot...

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Autores principales: Okamoto N, Watanabe K, Ngyuyen LH, Ikenouchi A, Kishi T, Iwata N, Kakeda S, Korogi Y, Yoshimura R
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2020
Materias:
kynurenine
major depression
neural network
source-based morphometry
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/ff33dc5428f34cfe815c9fb76c2675cd
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spelling oai:doaj.org-article:ff33dc5428f34cfe815c9fb76c2675cd2021-12-02T10:22:49ZAssociation of Serum Kynurenine Levels and Neural Networks in Patients with First-Episode, Drug-Naïve Major Depression: A Source-Based Morphometry Study1178-2021https://doaj.org/article/ff33dc5428f34cfe815c9fb76c2675cd2020-10-01T00:00:00Zhttps://www.dovepress.com/association-of-serum-kynurenine-levels-and-neural-networks-in-patients-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Naomichi Okamoto,1 Keita Watanabe,2 LeHoa Ngyuyen,1,3 Atsuko Ikenouchi,1 Taro Kishi,4 Nakao Iwata,4 Shingo Kakeda,5 Yukunori Korogi,6 Reiji Yoshimura1 1Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan; 2Open Innovation Institute, Kyoto University, Kyoto, Japan; 3School of Medicine and Pharmacy, Vietnam National University, Hanoi, Vietnam; 4Department of Psychiatry, Fujita Medical University, Toyoake, Japan; 5Department of Radiology, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan; 6Department of Radiology, University of Occupational and Environmental Health, Kitakyushu, JapanCorrespondence: Reiji YoshimuraDepartment of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Fukuoka 8078555, JapanTel +81 936917253Email yoshi621@med.uoeh-u.ac.jpPurpose: The kynurenine (KYN) pathway can directly or indirectly influence cerebral volume and neural integrity in patients with major depression (MD). The aim of the present study was to investigate neural network systems and the KYN pathway in patients with first-episode, drug-naïve MD.Patients and Methods: Twenty right-handed drug-naïve patients, with MD diagnosed using the Diagnostic and Statistical Manual for Mental Disorders, Fourth Edition, Text Revision, Research Version, were included in this study. Magnetic resonance imaging scans and scores on the Hamilton Rating Scale for Depression were assessed, and serum sampling was performed prior to the start of pharmacological treatment. Image processing and data analysis were performed according to our recently published procedure. Serum metabolomes were measured in the cation and anion modes of CE-FTMS-based metabolome analysis.Results: We found that serum KYN levels were positively correlated with the Z-scores of the salience network but not with those of the central executive network or default mode network. No associations were observed between serum glutamate levels and the Z-score of any of the three networks.Conclusion: Our results indicate that serum KYN levels might affect the activity of the salience network in first-episode, drug-naïve patients with MD.Keywords: kynurenine, major depression, neural network, source-based morphometryOkamoto NWatanabe KNgyuyen LHIkenouchi AKishi TIwata NKakeda SKorogi YYoshimura RDove Medical Pressarticlekynureninemajor depressionneural networksource-based morphometryNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 2569-2577 (2020)
institution DOAJ
collection DOAJ
language EN
topic kynurenine
major depression
neural network
source-based morphometry
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle kynurenine
major depression
neural network
source-based morphometry
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Okamoto N
Watanabe K
Ngyuyen LH
Ikenouchi A
Kishi T
Iwata N
Kakeda S
Korogi Y
Yoshimura R
Association of Serum Kynurenine Levels and Neural Networks in Patients with First-Episode, Drug-Naïve Major Depression: A Source-Based Morphometry Study
description Naomichi Okamoto,1 Keita Watanabe,2 LeHoa Ngyuyen,1,3 Atsuko Ikenouchi,1 Taro Kishi,4 Nakao Iwata,4 Shingo Kakeda,5 Yukunori Korogi,6 Reiji Yoshimura1 1Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan; 2Open Innovation Institute, Kyoto University, Kyoto, Japan; 3School of Medicine and Pharmacy, Vietnam National University, Hanoi, Vietnam; 4Department of Psychiatry, Fujita Medical University, Toyoake, Japan; 5Department of Radiology, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan; 6Department of Radiology, University of Occupational and Environmental Health, Kitakyushu, JapanCorrespondence: Reiji YoshimuraDepartment of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Fukuoka 8078555, JapanTel +81 936917253Email yoshi621@med.uoeh-u.ac.jpPurpose: The kynurenine (KYN) pathway can directly or indirectly influence cerebral volume and neural integrity in patients with major depression (MD). The aim of the present study was to investigate neural network systems and the KYN pathway in patients with first-episode, drug-naïve MD.Patients and Methods: Twenty right-handed drug-naïve patients, with MD diagnosed using the Diagnostic and Statistical Manual for Mental Disorders, Fourth Edition, Text Revision, Research Version, were included in this study. Magnetic resonance imaging scans and scores on the Hamilton Rating Scale for Depression were assessed, and serum sampling was performed prior to the start of pharmacological treatment. Image processing and data analysis were performed according to our recently published procedure. Serum metabolomes were measured in the cation and anion modes of CE-FTMS-based metabolome analysis.Results: We found that serum KYN levels were positively correlated with the Z-scores of the salience network but not with those of the central executive network or default mode network. No associations were observed between serum glutamate levels and the Z-score of any of the three networks.Conclusion: Our results indicate that serum KYN levels might affect the activity of the salience network in first-episode, drug-naïve patients with MD.Keywords: kynurenine, major depression, neural network, source-based morphometry
format article
author Okamoto N
Watanabe K
Ngyuyen LH
Ikenouchi A
Kishi T
Iwata N
Kakeda S
Korogi Y
Yoshimura R
author_facet Okamoto N
Watanabe K
Ngyuyen LH
Ikenouchi A
Kishi T
Iwata N
Kakeda S
Korogi Y
Yoshimura R
author_sort Okamoto N
title Association of Serum Kynurenine Levels and Neural Networks in Patients with First-Episode, Drug-Naïve Major Depression: A Source-Based Morphometry Study
title_short Association of Serum Kynurenine Levels and Neural Networks in Patients with First-Episode, Drug-Naïve Major Depression: A Source-Based Morphometry Study
title_full Association of Serum Kynurenine Levels and Neural Networks in Patients with First-Episode, Drug-Naïve Major Depression: A Source-Based Morphometry Study
title_fullStr Association of Serum Kynurenine Levels and Neural Networks in Patients with First-Episode, Drug-Naïve Major Depression: A Source-Based Morphometry Study
title_full_unstemmed Association of Serum Kynurenine Levels and Neural Networks in Patients with First-Episode, Drug-Naïve Major Depression: A Source-Based Morphometry Study
title_sort association of serum kynurenine levels and neural networks in patients with first-episode, drug-naïve major depression: a source-based morphometry study
publisher Dove Medical Press
publishDate 2020
url https://doaj.org/article/ff33dc5428f34cfe815c9fb76c2675cd
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