Analysis of the genetic predisposition to develop a Myocardial Infarction in a sample of Moroccan patients
Myocardial infarction (MI) is a multifactorial coronary artery disease influenced by environmental and genetic factors. Being one of the leading causes of morbidity and mortality in developed countries, it is becoming a national health concern in developing countries such as Morocco. In the present...
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| Autores principales: | , , , , , , , |
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| Formato: | article |
| Lenguaje: | EN FR |
| Publicado: |
EDP Sciences
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/ff341498e9284633a0c4ec60f24a4583 |
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| Sumario: | Myocardial infarction (MI) is a multifactorial coronary artery disease influenced by environmental and genetic factors. Being one of the leading causes of morbidity and mortality in developed countries, it is becoming a national health concern in developing countries such as Morocco. In the present work, we aim to study the association between 4 Alu polymorphisms (ACE, FXIII-B, TPA-25 and APOA1) genes and the risk of MI in the Moroccan population.
210 patients with a history of myocardial infarction and 203 healthy individuals were included in this study. The Alu polymorphisms were determined by the PCR technique followed by direct electrophoresis.
Only the I / I_APOA1 genotype showed a significant association with the risk of MI (p˂0.001; OR = 2.171), while genotypes carrying the D allele (D / D or I / D) showed a protective effect (p <0.001; OR = 0.46). Patients presenting an association between I / I and a high level of triglycerides (p = 0.020, OR = 2.14)), as well as a significant association with a high level of LDLs (p = 0.035, OR = 2, 00). Subjects carrying the I / I_APOA1 genotype with dyslipidemia or hyperglycemia are more likely to develop MI, as are those carrying I / D_APOA1 with hyperglycemia or high cholesterol. |
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