Analysis of the genetic predisposition to develop a Myocardial Infarction in a sample of Moroccan patients

Myocardial infarction (MI) is a multifactorial coronary artery disease influenced by environmental and genetic factors. Being one of the leading causes of morbidity and mortality in developed countries, it is becoming a national health concern in developing countries such as Morocco. In the present...

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Autores principales:	Anaibar Fatima Ezzahra, Essenhagi Sana, Abeid Said Nassor, Farhane Hamid, Motrane Majida, Habbal Rachida, Ghalim Norredine, Harich Nourdin
Formato:	article
Lenguaje:	EN FR
Publicado:	EDP Sciences 2021
Materias:	myocardial infarction polymorphism alu apoa1 hyperglycemia dyslipidemia Environmental sciences GE1-350
Acceso en línea:	https://doaj.org/article/ff341498e9284633a0c4ec60f24a4583
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spelling	oai:doaj.org-article:ff341498e9284633a0c4ec60f24a45832021-11-12T11:44:08ZAnalysis of the genetic predisposition to develop a Myocardial Infarction in a sample of Moroccan patients2267-124210.1051/e3sconf/202131901013https://doaj.org/article/ff341498e9284633a0c4ec60f24a45832021-01-01T00:00:00Zhttps://www.e3s-conferences.org/articles/e3sconf/pdf/2021/95/e3sconf_vigisan_01013.pdfhttps://doaj.org/toc/2267-1242Myocardial infarction (MI) is a multifactorial coronary artery disease influenced by environmental and genetic factors. Being one of the leading causes of morbidity and mortality in developed countries, it is becoming a national health concern in developing countries such as Morocco. In the present work, we aim to study the association between 4 Alu polymorphisms (ACE, FXIII-B, TPA-25 and APOA1) genes and the risk of MI in the Moroccan population. 210 patients with a history of myocardial infarction and 203 healthy individuals were included in this study. The Alu polymorphisms were determined by the PCR technique followed by direct electrophoresis. Only the I / I_APOA1 genotype showed a significant association with the risk of MI (p˂0.001; OR = 2.171), while genotypes carrying the D allele (D / D or I / D) showed a protective effect (p <0.001; OR = 0.46). Patients presenting an association between I / I and a high level of triglycerides (p = 0.020, OR = 2.14)), as well as a significant association with a high level of LDLs (p = 0.035, OR = 2, 00). Subjects carrying the I / I_APOA1 genotype with dyslipidemia or hyperglycemia are more likely to develop MI, as are those carrying I / D_APOA1 with hyperglycemia or high cholesterol.Anaibar Fatima EzzahraEssenhagi SanaAbeid Said NassorFarhane HamidMotrane MajidaHabbal RachidaGhalim NorredineHarich NourdinEDP Sciencesarticlemyocardial infarctionpolymorphismalu apoa1hyperglycemiadyslipidemiaEnvironmental sciencesGE1-350ENFRE3S Web of Conferences, Vol 319, p 01013 (2021)
institution	DOAJ
collection	DOAJ
language	EN FR
topic	myocardial infarction polymorphism alu apoa1 hyperglycemia dyslipidemia Environmental sciences GE1-350
spellingShingle	myocardial infarction polymorphism alu apoa1 hyperglycemia dyslipidemia Environmental sciences GE1-350 Anaibar Fatima Ezzahra Essenhagi Sana Abeid Said Nassor Farhane Hamid Motrane Majida Habbal Rachida Ghalim Norredine Harich Nourdin Analysis of the genetic predisposition to develop a Myocardial Infarction in a sample of Moroccan patients
description	Myocardial infarction (MI) is a multifactorial coronary artery disease influenced by environmental and genetic factors. Being one of the leading causes of morbidity and mortality in developed countries, it is becoming a national health concern in developing countries such as Morocco. In the present work, we aim to study the association between 4 Alu polymorphisms (ACE, FXIII-B, TPA-25 and APOA1) genes and the risk of MI in the Moroccan population. 210 patients with a history of myocardial infarction and 203 healthy individuals were included in this study. The Alu polymorphisms were determined by the PCR technique followed by direct electrophoresis. Only the I / I_APOA1 genotype showed a significant association with the risk of MI (p˂0.001; OR = 2.171), while genotypes carrying the D allele (D / D or I / D) showed a protective effect (p <0.001; OR = 0.46). Patients presenting an association between I / I and a high level of triglycerides (p = 0.020, OR = 2.14)), as well as a significant association with a high level of LDLs (p = 0.035, OR = 2, 00). Subjects carrying the I / I_APOA1 genotype with dyslipidemia or hyperglycemia are more likely to develop MI, as are those carrying I / D_APOA1 with hyperglycemia or high cholesterol.
format	article
author	Anaibar Fatima Ezzahra Essenhagi Sana Abeid Said Nassor Farhane Hamid Motrane Majida Habbal Rachida Ghalim Norredine Harich Nourdin
author_facet	Anaibar Fatima Ezzahra Essenhagi Sana Abeid Said Nassor Farhane Hamid Motrane Majida Habbal Rachida Ghalim Norredine Harich Nourdin
author_sort	Anaibar Fatima Ezzahra
title	Analysis of the genetic predisposition to develop a Myocardial Infarction in a sample of Moroccan patients
title_short	Analysis of the genetic predisposition to develop a Myocardial Infarction in a sample of Moroccan patients
title_full	Analysis of the genetic predisposition to develop a Myocardial Infarction in a sample of Moroccan patients
title_fullStr	Analysis of the genetic predisposition to develop a Myocardial Infarction in a sample of Moroccan patients
title_full_unstemmed	Analysis of the genetic predisposition to develop a Myocardial Infarction in a sample of Moroccan patients
title_sort	analysis of the genetic predisposition to develop a myocardial infarction in a sample of moroccan patients
publisher	EDP Sciences
publishDate	2021
url	https://doaj.org/article/ff341498e9284633a0c4ec60f24a4583
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Analysis of the genetic predisposition to develop a Myocardial Infarction in a sample of Moroccan patients

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