Saturated Fatty Acids in Obesity-Associated Inflammation

Heping Zhou, CJ Urso, Viren Jadeja Department of Biological Sciences, Seton Hall University, South Orange, NJ 07079, USACorrespondence: Heping Zhou Email heping.zhou@shu.eduAbstract: Obesity is a major risk factor for the development of various pathological conditions including insulin resistance, d...

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Autores principales:	Zhou H, Urso CJ, Jadeja V
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	saturated fatty acids obesity inflammation toll-like receptor reactive oxygen species lipid rafts protein kinase c Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/ff34f5f534cb4724834efc445d859148
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spelling	oai:doaj.org-article:ff34f5f534cb4724834efc445d8591482021-12-02T09:10:06ZSaturated Fatty Acids in Obesity-Associated Inflammation1178-7031https://doaj.org/article/ff34f5f534cb4724834efc445d8591482020-01-01T00:00:00Zhttps://www.dovepress.com/saturated-fatty-acids-in-obesity-associated-inflammation-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Heping Zhou, CJ Urso, Viren Jadeja Department of Biological Sciences, Seton Hall University, South Orange, NJ 07079, USACorrespondence: Heping Zhou Email heping.zhou@shu.eduAbstract: Obesity is a major risk factor for the development of various pathological conditions including insulin resistance, diabetes, cardiovascular diseases, and non-alcoholic fatty liver disease (NAFLD). Central to these conditions is obesity-associated chronic low-grade inflammation in many tissues including adipose, liver, muscle, kidney, pancreas, and brain. There is increasing evidence that saturated fatty acids (SFAs) increase the phosphorylation of MAPKs, enhance the activation of transcription factors such as nuclear factor (NF)-κB, and elevate the expression of inflammatory genes. This paper focuses on the mechanisms by which SFAs induce inflammation. SFAs may induce the expression inflammatory genes via different pathways including toll-like receptor (TLR), protein kinase C (PKC), reactive oxygen species (ROS), NOD-like receptors (NLRs), and endoplasmic reticulum (ER) stress. These findings suggest that SFAs act as an important link between obesity and inflammation.Keywords: saturated fatty acids, obesity, inflammation, Toll-like receptor, reactive oxygen species, lipid rafts, protein kinase CZhou HUrso CJJadeja VDove Medical Pressarticlesaturated fatty acidsobesityinflammationtoll-like receptorreactive oxygen specieslipid raftsprotein kinase cPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 13, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	saturated fatty acids obesity inflammation toll-like receptor reactive oxygen species lipid rafts protein kinase c Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	saturated fatty acids obesity inflammation toll-like receptor reactive oxygen species lipid rafts protein kinase c Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Zhou H Urso CJ Jadeja V Saturated Fatty Acids in Obesity-Associated Inflammation
description	Heping Zhou, CJ Urso, Viren Jadeja Department of Biological Sciences, Seton Hall University, South Orange, NJ 07079, USACorrespondence: Heping Zhou Email heping.zhou@shu.eduAbstract: Obesity is a major risk factor for the development of various pathological conditions including insulin resistance, diabetes, cardiovascular diseases, and non-alcoholic fatty liver disease (NAFLD). Central to these conditions is obesity-associated chronic low-grade inflammation in many tissues including adipose, liver, muscle, kidney, pancreas, and brain. There is increasing evidence that saturated fatty acids (SFAs) increase the phosphorylation of MAPKs, enhance the activation of transcription factors such as nuclear factor (NF)-κB, and elevate the expression of inflammatory genes. This paper focuses on the mechanisms by which SFAs induce inflammation. SFAs may induce the expression inflammatory genes via different pathways including toll-like receptor (TLR), protein kinase C (PKC), reactive oxygen species (ROS), NOD-like receptors (NLRs), and endoplasmic reticulum (ER) stress. These findings suggest that SFAs act as an important link between obesity and inflammation.Keywords: saturated fatty acids, obesity, inflammation, Toll-like receptor, reactive oxygen species, lipid rafts, protein kinase C
format	article
author	Zhou H Urso CJ Jadeja V
author_facet	Zhou H Urso CJ Jadeja V
author_sort	Zhou H
title	Saturated Fatty Acids in Obesity-Associated Inflammation
title_short	Saturated Fatty Acids in Obesity-Associated Inflammation
title_full	Saturated Fatty Acids in Obesity-Associated Inflammation
title_fullStr	Saturated Fatty Acids in Obesity-Associated Inflammation
title_full_unstemmed	Saturated Fatty Acids in Obesity-Associated Inflammation
title_sort	saturated fatty acids in obesity-associated inflammation
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/ff34f5f534cb4724834efc445d859148
work_keys_str_mv	AT zhouh saturatedfattyacidsinobesityassociatedinflammation AT ursocj saturatedfattyacidsinobesityassociatedinflammation AT jadejav saturatedfattyacidsinobesityassociatedinflammation
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Saturated Fatty Acids in Obesity-Associated Inflammation

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