Habitual coffee consumption and cognitive function: a Mendelian randomization meta-analysis in up to 415,530 participants

Abstract Coffee’s long-term effect on cognitive function remains unclear with studies suggesting both benefits and adverse effects. We used Mendelian randomization to investigate the causal relationship between habitual coffee consumption and cognitive function in mid- to later life. This included u...

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Autores principales:	Ang Zhou, Amy E. Taylor, Ville Karhunen, Yiqiang Zhan, Suvi P. Rovio, Jari Lahti, Per Sjögren, Liisa Byberg, Donald M. Lyall, Juha Auvinen, Terho Lehtimäki, Mika Kähönen, Nina Hutri-Kähönen, Mia Maria Perälä, Karl Michaëlsson, Anubha Mahajan, Lars Lind, Chris Power, Johan G. Eriksson, Olli T. Raitakari, Sara Hägg, Nancy L. Pedersen, Juha Veijola, Marjo-Riitta Järvelin, Marcus R. Munafò, Erik Ingelsson, David J. Llewellyn, Elina Hyppönen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ff35a6f4555646e3874ce66b66fa2ef7
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spelling	oai:doaj.org-article:ff35a6f4555646e3874ce66b66fa2ef72021-12-02T16:08:01ZHabitual coffee consumption and cognitive function: a Mendelian randomization meta-analysis in up to 415,530 participants10.1038/s41598-018-25919-22045-2322https://doaj.org/article/ff35a6f4555646e3874ce66b66fa2ef72018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25919-2https://doaj.org/toc/2045-2322Abstract Coffee’s long-term effect on cognitive function remains unclear with studies suggesting both benefits and adverse effects. We used Mendelian randomization to investigate the causal relationship between habitual coffee consumption and cognitive function in mid- to later life. This included up to 415,530 participants and 300,760 coffee drinkers from 10 meta-analysed European ancestry cohorts. In each cohort, composite cognitive scores that capture global cognition and memory were computed using available tests. A genetic score derived using CYP1A1/2 (rs2472297) and AHR (rs6968865) was chosen as a proxy for habitual coffee consumption. Null associations were observed when examining the associations of the genetic score with global and memory cognition (β = −0.0007, 95% C.I. −0.009 to 0.008, P = 0.87; β = −0.001, 95% C.I. −0.005 to 0.002, P = 0.51, respectively), with high consistency between studies (Pheterogeneity > 0.4 for both). Domain specific analyses using available cognitive measures in the UK Biobank also did not support effects by habitual coffee intake for reaction time, pairs matching, reasoning or prospective memory (P ≥ 0.05 for all). Despite the power to detect very small effects, our meta-analysis provided no evidence for causal long-term effects of habitual coffee consumption on global cognition or memory.Ang ZhouAmy E. TaylorVille KarhunenYiqiang ZhanSuvi P. RovioJari LahtiPer SjögrenLiisa BybergDonald M. LyallJuha AuvinenTerho LehtimäkiMika KähönenNina Hutri-KähönenMia Maria PeräläKarl MichaëlssonAnubha MahajanLars LindChris PowerJohan G. ErikssonOlli T. RaitakariSara HäggNancy L. PedersenJuha VeijolaMarjo-Riitta JärvelinMarcus R. MunafòErik IngelssonDavid J. LlewellynElina HyppönenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ang Zhou Amy E. Taylor Ville Karhunen Yiqiang Zhan Suvi P. Rovio Jari Lahti Per Sjögren Liisa Byberg Donald M. Lyall Juha Auvinen Terho Lehtimäki Mika Kähönen Nina Hutri-Kähönen Mia Maria Perälä Karl Michaëlsson Anubha Mahajan Lars Lind Chris Power Johan G. Eriksson Olli T. Raitakari Sara Hägg Nancy L. Pedersen Juha Veijola Marjo-Riitta Järvelin Marcus R. Munafò Erik Ingelsson David J. Llewellyn Elina Hyppönen Habitual coffee consumption and cognitive function: a Mendelian randomization meta-analysis in up to 415,530 participants
description	Abstract Coffee’s long-term effect on cognitive function remains unclear with studies suggesting both benefits and adverse effects. We used Mendelian randomization to investigate the causal relationship between habitual coffee consumption and cognitive function in mid- to later life. This included up to 415,530 participants and 300,760 coffee drinkers from 10 meta-analysed European ancestry cohorts. In each cohort, composite cognitive scores that capture global cognition and memory were computed using available tests. A genetic score derived using CYP1A1/2 (rs2472297) and AHR (rs6968865) was chosen as a proxy for habitual coffee consumption. Null associations were observed when examining the associations of the genetic score with global and memory cognition (β = −0.0007, 95% C.I. −0.009 to 0.008, P = 0.87; β = −0.001, 95% C.I. −0.005 to 0.002, P = 0.51, respectively), with high consistency between studies (Pheterogeneity > 0.4 for both). Domain specific analyses using available cognitive measures in the UK Biobank also did not support effects by habitual coffee intake for reaction time, pairs matching, reasoning or prospective memory (P ≥ 0.05 for all). Despite the power to detect very small effects, our meta-analysis provided no evidence for causal long-term effects of habitual coffee consumption on global cognition or memory.
format	article
author	Ang Zhou Amy E. Taylor Ville Karhunen Yiqiang Zhan Suvi P. Rovio Jari Lahti Per Sjögren Liisa Byberg Donald M. Lyall Juha Auvinen Terho Lehtimäki Mika Kähönen Nina Hutri-Kähönen Mia Maria Perälä Karl Michaëlsson Anubha Mahajan Lars Lind Chris Power Johan G. Eriksson Olli T. Raitakari Sara Hägg Nancy L. Pedersen Juha Veijola Marjo-Riitta Järvelin Marcus R. Munafò Erik Ingelsson David J. Llewellyn Elina Hyppönen
author_facet	Ang Zhou Amy E. Taylor Ville Karhunen Yiqiang Zhan Suvi P. Rovio Jari Lahti Per Sjögren Liisa Byberg Donald M. Lyall Juha Auvinen Terho Lehtimäki Mika Kähönen Nina Hutri-Kähönen Mia Maria Perälä Karl Michaëlsson Anubha Mahajan Lars Lind Chris Power Johan G. Eriksson Olli T. Raitakari Sara Hägg Nancy L. Pedersen Juha Veijola Marjo-Riitta Järvelin Marcus R. Munafò Erik Ingelsson David J. Llewellyn Elina Hyppönen
author_sort	Ang Zhou
title	Habitual coffee consumption and cognitive function: a Mendelian randomization meta-analysis in up to 415,530 participants
title_short	Habitual coffee consumption and cognitive function: a Mendelian randomization meta-analysis in up to 415,530 participants
title_full	Habitual coffee consumption and cognitive function: a Mendelian randomization meta-analysis in up to 415,530 participants
title_fullStr	Habitual coffee consumption and cognitive function: a Mendelian randomization meta-analysis in up to 415,530 participants
title_full_unstemmed	Habitual coffee consumption and cognitive function: a Mendelian randomization meta-analysis in up to 415,530 participants
title_sort	habitual coffee consumption and cognitive function: a mendelian randomization meta-analysis in up to 415,530 participants
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ff35a6f4555646e3874ce66b66fa2ef7
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Habitual coffee consumption and cognitive function: a Mendelian randomization meta-analysis in up to 415,530 participants

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