Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1

The tumor microenviroment can influence cancer progression and response to therapy. In this study, the authors show that miR21 is transferred through exosomes from cancer-associated fibroblasts and adipocytes to ovarian cancer cells where it modulates drug resistance by its direct target APAF1.

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Autores principales:	Chi Lam Au Yeung, Ngai-Na Co, Tetsushi Tsuruga, Tsz-Lun Yeung, Suet-Ying Kwan, Cecilia S. Leung, Yong Li, Edward S. Lu, Kenny Kwan, Kwong-Kwok Wong, Rosemarie Schmandt, Karen H. Lu, Samuel C. Mok
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ff39043eef974cb8bf3b0f0a415eb6b1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:ff39043eef974cb8bf3b0f0a415eb6b12021-12-02T15:34:55ZExosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF110.1038/ncomms111502041-1723https://doaj.org/article/ff39043eef974cb8bf3b0f0a415eb6b12016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms11150https://doaj.org/toc/2041-1723The tumor microenviroment can influence cancer progression and response to therapy. In this study, the authors show that miR21 is transferred through exosomes from cancer-associated fibroblasts and adipocytes to ovarian cancer cells where it modulates drug resistance by its direct target APAF1.Chi Lam Au YeungNgai-Na CoTetsushi TsurugaTsz-Lun YeungSuet-Ying KwanCecilia S. LeungYong LiEdward S. LuKenny KwanKwong-Kwok WongRosemarie SchmandtKaren H. LuSamuel C. MokNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chi Lam Au Yeung Ngai-Na Co Tetsushi Tsuruga Tsz-Lun Yeung Suet-Ying Kwan Cecilia S. Leung Yong Li Edward S. Lu Kenny Kwan Kwong-Kwok Wong Rosemarie Schmandt Karen H. Lu Samuel C. Mok Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1
description	The tumor microenviroment can influence cancer progression and response to therapy. In this study, the authors show that miR21 is transferred through exosomes from cancer-associated fibroblasts and adipocytes to ovarian cancer cells where it modulates drug resistance by its direct target APAF1.
format	article
author	Chi Lam Au Yeung Ngai-Na Co Tetsushi Tsuruga Tsz-Lun Yeung Suet-Ying Kwan Cecilia S. Leung Yong Li Edward S. Lu Kenny Kwan Kwong-Kwok Wong Rosemarie Schmandt Karen H. Lu Samuel C. Mok
author_facet	Chi Lam Au Yeung Ngai-Na Co Tetsushi Tsuruga Tsz-Lun Yeung Suet-Ying Kwan Cecilia S. Leung Yong Li Edward S. Lu Kenny Kwan Kwong-Kwok Wong Rosemarie Schmandt Karen H. Lu Samuel C. Mok
author_sort	Chi Lam Au Yeung
title	Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1
title_short	Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1
title_full	Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1
title_fullStr	Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1
title_full_unstemmed	Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1
title_sort	exosomal transfer of stroma-derived mir21 confers paclitaxel resistance in ovarian cancer cells through targeting apaf1
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/ff39043eef974cb8bf3b0f0a415eb6b1
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Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1

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