Short term and Long term Survival Rate and Risk Factors of Graft Rejection after Deceased Donor Kidney Transplantation: A Systematic Review and Meta-Analysis

Introduction: The purpose of the current meta-analysis was to determine the short-term and long-term graft survival and patient survival from the deceased donors, and determine the prognostic factors. Methods: PubMed, Scopus, and Google Scholar databases were searched in March 2019 to obtain articl...

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Autores principales:	Behzad Narouie, Mohammad Saatchi
Formato:	article
Lenguaje:	EN
Publicado:	Urology Research Center 2021
Materias:	graft survival patient survival deceased donor systematic review and meta-analysis Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/ff39a733f07a4d6fa0b72c49f802e116
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spelling	oai:doaj.org-article:ff39a733f07a4d6fa0b72c49f802e1162021-11-30T07:57:36ZShort term and Long term Survival Rate and Risk Factors of Graft Rejection after Deceased Donor Kidney Transplantation: A Systematic Review and Meta-Analysis10.22034/TRU.2021.284800.10662717-042Xhttps://doaj.org/article/ff39a733f07a4d6fa0b72c49f802e1162021-08-01T00:00:00Zhttps://www.transresurology.com/article_134376.htmlhttps://doaj.org/toc/2717-042XIntroduction: The purpose of the current meta-analysis was to determine the short-term and long-term graft survival and patient survival from the deceased donors, and determine the prognostic factors. Methods: PubMed, Scopus, and Google Scholar databases were searched in March 2019 to obtain articles that report short-term and/or long-term graft and patient survival. The study also includes articles that analyzed the hazard ratio (HR) of graft rejection or patient death for deceased donor risk-related factors. The measures in this study could be summarized as the survival rate and the HR of graft rejection and patient death. Results: In the final analysis, 75 articles were included. The 1- and 5-year graft survival were 90% and 76%, and for patient survival were 95% and 85% respectively. The 1- and 5-year graft survival in transplant donation after brain death (DBD) recipients were 92% and 79% and for patient survival were 94% and 90% respectively. The 1- year graft and patient survival in donation after circulatory death (DCD) recipients were 87% and 95%, respectively. Also, the 1- and 5-year graft survival in patient expanded-criteria donors (ECDs) were 88% and 68%, and for patient survival were 93% and 87%, respectively. The 1-year graft survival in standard-criteria donors (SCDs) recipients was 93%, and 1- and 5-year patient survivals were 96% and 92%. Age of deceased donor, ECD kidney, and male sex were the significant prognostic factors for graft rejection. Conclusions: The findings of the first comprehensive meta-analysis of graft and patient survival of the deceased donor showed that the overall short-term and long-term graft and patient survival are desirable and confirm that ECD and DCD recipients have a poorer graft survival chance than standard donors.Behzad Narouie Mohammad SaatchiUrology Research Centerarticlegraft survivalpatient survivaldeceased donorsystematic review and meta-analysisDiseases of the genitourinary system. UrologyRC870-923ENTranslational Research in Urology, Vol 3, Iss 3, Pp 95-114 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	graft survival patient survival deceased donor systematic review and meta-analysis Diseases of the genitourinary system. Urology RC870-923
spellingShingle	graft survival patient survival deceased donor systematic review and meta-analysis Diseases of the genitourinary system. Urology RC870-923 Behzad Narouie Mohammad Saatchi Short term and Long term Survival Rate and Risk Factors of Graft Rejection after Deceased Donor Kidney Transplantation: A Systematic Review and Meta-Analysis
description	Introduction: The purpose of the current meta-analysis was to determine the short-term and long-term graft survival and patient survival from the deceased donors, and determine the prognostic factors. Methods: PubMed, Scopus, and Google Scholar databases were searched in March 2019 to obtain articles that report short-term and/or long-term graft and patient survival. The study also includes articles that analyzed the hazard ratio (HR) of graft rejection or patient death for deceased donor risk-related factors. The measures in this study could be summarized as the survival rate and the HR of graft rejection and patient death. Results: In the final analysis, 75 articles were included. The 1- and 5-year graft survival were 90% and 76%, and for patient survival were 95% and 85% respectively. The 1- and 5-year graft survival in transplant donation after brain death (DBD) recipients were 92% and 79% and for patient survival were 94% and 90% respectively. The 1- year graft and patient survival in donation after circulatory death (DCD) recipients were 87% and 95%, respectively. Also, the 1- and 5-year graft survival in patient expanded-criteria donors (ECDs) were 88% and 68%, and for patient survival were 93% and 87%, respectively. The 1-year graft survival in standard-criteria donors (SCDs) recipients was 93%, and 1- and 5-year patient survivals were 96% and 92%. Age of deceased donor, ECD kidney, and male sex were the significant prognostic factors for graft rejection. Conclusions: The findings of the first comprehensive meta-analysis of graft and patient survival of the deceased donor showed that the overall short-term and long-term graft and patient survival are desirable and confirm that ECD and DCD recipients have a poorer graft survival chance than standard donors.
format	article
author	Behzad Narouie Mohammad Saatchi
author_facet	Behzad Narouie Mohammad Saatchi
author_sort	Behzad Narouie
title	Short term and Long term Survival Rate and Risk Factors of Graft Rejection after Deceased Donor Kidney Transplantation: A Systematic Review and Meta-Analysis
title_short	Short term and Long term Survival Rate and Risk Factors of Graft Rejection after Deceased Donor Kidney Transplantation: A Systematic Review and Meta-Analysis
title_full	Short term and Long term Survival Rate and Risk Factors of Graft Rejection after Deceased Donor Kidney Transplantation: A Systematic Review and Meta-Analysis
title_fullStr	Short term and Long term Survival Rate and Risk Factors of Graft Rejection after Deceased Donor Kidney Transplantation: A Systematic Review and Meta-Analysis
title_full_unstemmed	Short term and Long term Survival Rate and Risk Factors of Graft Rejection after Deceased Donor Kidney Transplantation: A Systematic Review and Meta-Analysis
title_sort	short term and long term survival rate and risk factors of graft rejection after deceased donor kidney transplantation: a systematic review and meta-analysis
publisher	Urology Research Center
publishDate	2021
url	https://doaj.org/article/ff39a733f07a4d6fa0b72c49f802e116
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Short term and Long term Survival Rate and Risk Factors of Graft Rejection after Deceased Donor Kidney Transplantation: A Systematic Review and Meta-Analysis

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