The ins and outs of the BCCAo model for chronic hypoperfusion: a multimodal and longitudinal MRI approach.

Cerebral hypoperfusion induced by bilateral common carotid artery occlusion (BCCAo) in rodents has been proposed as an experimental model of white matter damage and vascular dementia. However, the histopathological and behavioral alterations reported in this model are variable and a full characteriz...

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Autores principales:	Guadalupe Soria, Raúl Tudela, Ana Márquez-Martín, Lluïsa Camón, Dafnis Batalle, Emma Muñoz-Moreno, Elisenda Eixarch, Josep Puig, Salvador Pedraza, Elisabet Vila, Alberto Prats-Galino, Anna M Planas
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ff40552ac3074053828586162ab284c7
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spelling	oai:doaj.org-article:ff40552ac3074053828586162ab284c72021-11-18T08:54:43ZThe ins and outs of the BCCAo model for chronic hypoperfusion: a multimodal and longitudinal MRI approach.1932-620310.1371/journal.pone.0074631https://doaj.org/article/ff40552ac3074053828586162ab284c72013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24058609/?tool=EBIhttps://doaj.org/toc/1932-6203Cerebral hypoperfusion induced by bilateral common carotid artery occlusion (BCCAo) in rodents has been proposed as an experimental model of white matter damage and vascular dementia. However, the histopathological and behavioral alterations reported in this model are variable and a full characterization of the dynamic alterations is not available. Here we implemented a longitudinal multimodal magnetic resonance imaging (MRI) design, including time-of-flight angiography, high resolution T1-weighted images, T2 relaxometry mapping, diffusion tensor imaging, and cerebral blood flow measurements up to 12 weeks after BCCAo or sham-operation in Wistar rats. Changes in MRI were related to behavioral performance in executive function tasks and histopathological alterations in the same animals. MRI frequently (70%) showed various degrees of acute ischemic lesions, ranging from very small to large subcortical infarctions. Independently, delayed MRI changes were also apparent. The patterns of MRI alterations were related to either ischemic necrosis or gliosis. Progressive microstructural changes revealed by diffusion tensor imaging in white matter were confirmed by observation of myelinated fiber degeneration, including severe optic tract degeneration. The latter interfered with the visually cued learning paradigms used to test executive functions. Independently of brain damage, BCCAo induced progressive arteriogenesis in the vertebrobasilar tree, a process that was associated with blood flow recovery after 12 weeks. The structural alterations found in the basilar artery were compatible with compensatory adaptive changes driven by shear stress. In summary, BCCAo in rats induces specific signatures in multimodal MRI that are compatible with various types of histological lesion and with marked adaptive arteriogenesis.Guadalupe SoriaRaúl TudelaAna Márquez-MartínLluïsa CamónDafnis BatalleEmma Muñoz-MorenoElisenda EixarchJosep PuigSalvador PedrazaElisabet VilaAlberto Prats-GalinoAnna M PlanasPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e74631 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Guadalupe Soria Raúl Tudela Ana Márquez-Martín Lluïsa Camón Dafnis Batalle Emma Muñoz-Moreno Elisenda Eixarch Josep Puig Salvador Pedraza Elisabet Vila Alberto Prats-Galino Anna M Planas The ins and outs of the BCCAo model for chronic hypoperfusion: a multimodal and longitudinal MRI approach.
description	Cerebral hypoperfusion induced by bilateral common carotid artery occlusion (BCCAo) in rodents has been proposed as an experimental model of white matter damage and vascular dementia. However, the histopathological and behavioral alterations reported in this model are variable and a full characterization of the dynamic alterations is not available. Here we implemented a longitudinal multimodal magnetic resonance imaging (MRI) design, including time-of-flight angiography, high resolution T1-weighted images, T2 relaxometry mapping, diffusion tensor imaging, and cerebral blood flow measurements up to 12 weeks after BCCAo or sham-operation in Wistar rats. Changes in MRI were related to behavioral performance in executive function tasks and histopathological alterations in the same animals. MRI frequently (70%) showed various degrees of acute ischemic lesions, ranging from very small to large subcortical infarctions. Independently, delayed MRI changes were also apparent. The patterns of MRI alterations were related to either ischemic necrosis or gliosis. Progressive microstructural changes revealed by diffusion tensor imaging in white matter were confirmed by observation of myelinated fiber degeneration, including severe optic tract degeneration. The latter interfered with the visually cued learning paradigms used to test executive functions. Independently of brain damage, BCCAo induced progressive arteriogenesis in the vertebrobasilar tree, a process that was associated with blood flow recovery after 12 weeks. The structural alterations found in the basilar artery were compatible with compensatory adaptive changes driven by shear stress. In summary, BCCAo in rats induces specific signatures in multimodal MRI that are compatible with various types of histological lesion and with marked adaptive arteriogenesis.
format	article
author	Guadalupe Soria Raúl Tudela Ana Márquez-Martín Lluïsa Camón Dafnis Batalle Emma Muñoz-Moreno Elisenda Eixarch Josep Puig Salvador Pedraza Elisabet Vila Alberto Prats-Galino Anna M Planas
author_facet	Guadalupe Soria Raúl Tudela Ana Márquez-Martín Lluïsa Camón Dafnis Batalle Emma Muñoz-Moreno Elisenda Eixarch Josep Puig Salvador Pedraza Elisabet Vila Alberto Prats-Galino Anna M Planas
author_sort	Guadalupe Soria
title	The ins and outs of the BCCAo model for chronic hypoperfusion: a multimodal and longitudinal MRI approach.
title_short	The ins and outs of the BCCAo model for chronic hypoperfusion: a multimodal and longitudinal MRI approach.
title_full	The ins and outs of the BCCAo model for chronic hypoperfusion: a multimodal and longitudinal MRI approach.
title_fullStr	The ins and outs of the BCCAo model for chronic hypoperfusion: a multimodal and longitudinal MRI approach.
title_full_unstemmed	The ins and outs of the BCCAo model for chronic hypoperfusion: a multimodal and longitudinal MRI approach.
title_sort	ins and outs of the bccao model for chronic hypoperfusion: a multimodal and longitudinal mri approach.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/ff40552ac3074053828586162ab284c7
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The ins and outs of the BCCAo model for chronic hypoperfusion: a multimodal and longitudinal MRI approach.

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