Zinc status in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis of observational studies

Abstract Previous studies regarding the zinc status in attention-deficit/hyperactivity disorder (ADHD) yielded inconsistent results. Thus, the present meta-analysis was aimed to estimate the association between hair and serum/plasma zinc levels and ADHD. Online databases of Medline, EMBASE, and Scop...

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Autores principales:	Seyed Mojtaba Ghoreishy, Sara Ebrahimi Mousavi, Farzaneh Asoudeh, Hamed Mohammadi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ff409869e4564300a90527ca1439136a
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spelling	oai:doaj.org-article:ff409869e4564300a90527ca1439136a2021-12-02T15:33:01ZZinc status in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis of observational studies10.1038/s41598-021-94124-52045-2322https://doaj.org/article/ff409869e4564300a90527ca1439136a2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94124-5https://doaj.org/toc/2045-2322Abstract Previous studies regarding the zinc status in attention-deficit/hyperactivity disorder (ADHD) yielded inconsistent results. Thus, the present meta-analysis was aimed to estimate the association between hair and serum/plasma zinc levels and ADHD. Online databases of Medline, EMBASE, and Scopus were searched up to October 2020 with no limitation in time and language. Weighted mean differences (WMDs) of hair and serum/plasma zinc levels were calculated using a random-effects model. Overall, 22 articles with 1280 subjects with ADHD and 1200 controls were included. The pooled effect size indicated that serum/plasma zinc levels in subjects with ADHD were not statistically different than their controls (WMD = − 1.26 µmol/L; 95% CI − 3.72, 1.20). Interestingly, the exclusion of one study from the analysis showed that people with ADHD significantly have lower circulating levels of zinc compared to their controls (WMD: − 2.49 µmol/L; 95% CI − 4.29, − 0.69). Also, the pooled effect size indicated that hair zinc levels in cases with ADHD were not statistically different than their controls (WMD = − 24.19 μg/g; 95% CI − 61.80, 13.42). Present meta-analysis raises the possibility that subjects with ADHD are prone to have declined levels of zinc levels. Based on current findings, screening the zinc levels in subjects with ADHD could be reasonable. Further well-designed studies are needed to clarify the role of zinc in the etiology of ADHD.Seyed Mojtaba GhoreishySara Ebrahimi MousaviFarzaneh AsoudehHamed MohammadiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Seyed Mojtaba Ghoreishy Sara Ebrahimi Mousavi Farzaneh Asoudeh Hamed Mohammadi Zinc status in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis of observational studies
description	Abstract Previous studies regarding the zinc status in attention-deficit/hyperactivity disorder (ADHD) yielded inconsistent results. Thus, the present meta-analysis was aimed to estimate the association between hair and serum/plasma zinc levels and ADHD. Online databases of Medline, EMBASE, and Scopus were searched up to October 2020 with no limitation in time and language. Weighted mean differences (WMDs) of hair and serum/plasma zinc levels were calculated using a random-effects model. Overall, 22 articles with 1280 subjects with ADHD and 1200 controls were included. The pooled effect size indicated that serum/plasma zinc levels in subjects with ADHD were not statistically different than their controls (WMD = − 1.26 µmol/L; 95% CI − 3.72, 1.20). Interestingly, the exclusion of one study from the analysis showed that people with ADHD significantly have lower circulating levels of zinc compared to their controls (WMD: − 2.49 µmol/L; 95% CI − 4.29, − 0.69). Also, the pooled effect size indicated that hair zinc levels in cases with ADHD were not statistically different than their controls (WMD = − 24.19 μg/g; 95% CI − 61.80, 13.42). Present meta-analysis raises the possibility that subjects with ADHD are prone to have declined levels of zinc levels. Based on current findings, screening the zinc levels in subjects with ADHD could be reasonable. Further well-designed studies are needed to clarify the role of zinc in the etiology of ADHD.
format	article
author	Seyed Mojtaba Ghoreishy Sara Ebrahimi Mousavi Farzaneh Asoudeh Hamed Mohammadi
author_facet	Seyed Mojtaba Ghoreishy Sara Ebrahimi Mousavi Farzaneh Asoudeh Hamed Mohammadi
author_sort	Seyed Mojtaba Ghoreishy
title	Zinc status in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis of observational studies
title_short	Zinc status in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis of observational studies
title_full	Zinc status in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis of observational studies
title_fullStr	Zinc status in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis of observational studies
title_full_unstemmed	Zinc status in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis of observational studies
title_sort	zinc status in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis of observational studies
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ff409869e4564300a90527ca1439136a
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Zinc status in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis of observational studies

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