Trauma-induced regulation of VHP-1 modulates the cellular response to mechanical stress
The nervous system utilizes adaptive strategies to mitigate trauma-induced neurodegeneration. Here, the authors report that a MAPK phosphatase VHP-1 is induced by trauma and regulates transcriptional responses to mechanical stress in a C. elegans model.
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Nature Portfolio
2021
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oai:doaj.org-article:ff44cb20fe82453182d0e975c52b4f952021-12-02T13:14:53ZTrauma-induced regulation of VHP-1 modulates the cellular response to mechanical stress10.1038/s41467-021-21611-82041-1723https://doaj.org/article/ff44cb20fe82453182d0e975c52b4f952021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21611-8https://doaj.org/toc/2041-1723The nervous system utilizes adaptive strategies to mitigate trauma-induced neurodegeneration. Here, the authors report that a MAPK phosphatase VHP-1 is induced by trauma and regulates transcriptional responses to mechanical stress in a C. elegans model.Nathan EggeSonja L. B. ArneaudRene Solano FonsecaKielen R. ZuurbierJacob McClendonPeter M. DouglasNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021) |
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Science Q Nathan Egge Sonja L. B. Arneaud Rene Solano Fonseca Kielen R. Zuurbier Jacob McClendon Peter M. Douglas Trauma-induced regulation of VHP-1 modulates the cellular response to mechanical stress |
description |
The nervous system utilizes adaptive strategies to mitigate trauma-induced neurodegeneration. Here, the authors report that a MAPK phosphatase VHP-1 is induced by trauma and regulates transcriptional responses to mechanical stress in a C. elegans model. |
format |
article |
author |
Nathan Egge Sonja L. B. Arneaud Rene Solano Fonseca Kielen R. Zuurbier Jacob McClendon Peter M. Douglas |
author_facet |
Nathan Egge Sonja L. B. Arneaud Rene Solano Fonseca Kielen R. Zuurbier Jacob McClendon Peter M. Douglas |
author_sort |
Nathan Egge |
title |
Trauma-induced regulation of VHP-1 modulates the cellular response to mechanical stress |
title_short |
Trauma-induced regulation of VHP-1 modulates the cellular response to mechanical stress |
title_full |
Trauma-induced regulation of VHP-1 modulates the cellular response to mechanical stress |
title_fullStr |
Trauma-induced regulation of VHP-1 modulates the cellular response to mechanical stress |
title_full_unstemmed |
Trauma-induced regulation of VHP-1 modulates the cellular response to mechanical stress |
title_sort |
trauma-induced regulation of vhp-1 modulates the cellular response to mechanical stress |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/ff44cb20fe82453182d0e975c52b4f95 |
work_keys_str_mv |
AT nathanegge traumainducedregulationofvhp1modulatesthecellularresponsetomechanicalstress AT sonjalbarneaud traumainducedregulationofvhp1modulatesthecellularresponsetomechanicalstress AT renesolanofonseca traumainducedregulationofvhp1modulatesthecellularresponsetomechanicalstress AT kielenrzuurbier traumainducedregulationofvhp1modulatesthecellularresponsetomechanicalstress AT jacobmcclendon traumainducedregulationofvhp1modulatesthecellularresponsetomechanicalstress AT petermdouglas traumainducedregulationofvhp1modulatesthecellularresponsetomechanicalstress |
_version_ |
1718393428088193024 |