Capsular contracture by silicone breast implants: possible causes, biocompatibility, and prophylactic strategies

Andreas E Steiert, Maria Boyce, Heiko Sorg Department of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Hannover, Germany Abstract: The most common implanted material in the human body consists of silicone. Breast augmentation and breast reconstruction using silicone-based implan...

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Autores principales:	Steiert AE, Boyce M, Sorg H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/ff45716b79af49fbb0403989af10c470
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spelling	oai:doaj.org-article:ff45716b79af49fbb0403989af10c4702021-12-02T01:17:14ZCapsular contracture by silicone breast implants: possible causes, biocompatibility, and prophylactic strategies1179-1470https://doaj.org/article/ff45716b79af49fbb0403989af10c4702013-12-01T00:00:00Zhttp://www.dovepress.com/capsular-contracture-by-silicone-breast-implants-possible-causes-bioco-a15144https://doaj.org/toc/1179-1470Andreas E Steiert, Maria Boyce, Heiko Sorg Department of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Hannover, Germany Abstract: The most common implanted material in the human body consists of silicone. Breast augmentation and breast reconstruction using silicone-based implants are procedures frequently performed by reconstructive and aesthetic surgeons. A main complication of this procedure continues to be the development of capsular contracture (CC), displaying the result of a fibrotic foreign body reaction after the implantation of silicone. For many years, experimental and clinical trials have attempted to analyze the problem of its etiology, treatment, and prophylaxis. Different theories of CC formation are known; however, the reason why different individuals develop CC in days or a month, or only after years, is unknown. Therefore, we hypothesize that CC formation, might primarily be induced by immunological mechanisms along with other reasons. This article attempts to review CC formation, with special attention paid to immunological and inflammatory reasons, as well as actual prophylactic strategies. In this context, the word “biocompatibility” has been frequently used to describe the overall biological innocuousness of silicone in the respective studies, although without clear-cut definitions of this important feature. We have therefore developed a new five-point scale with distinct key points of biocompatibility. Hence, this article might provide the basis for ongoing discussion in this field to reduce single-publication definitions as well as increase the understanding of biocompatibility. Keywords: biofilm, foreign body reaction, breast augmentation, biocompatibility, fibrosisSteiert AEBoyce MSorg HDove Medical PressarticleMedical technologyR855-855.5ENMedical Devices: Evidence and Research, Vol 2013, Iss default, Pp 211-218 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medical technology R855-855.5
spellingShingle	Medical technology R855-855.5 Steiert AE Boyce M Sorg H Capsular contracture by silicone breast implants: possible causes, biocompatibility, and prophylactic strategies
description	Andreas E Steiert, Maria Boyce, Heiko Sorg Department of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Hannover, Germany Abstract: The most common implanted material in the human body consists of silicone. Breast augmentation and breast reconstruction using silicone-based implants are procedures frequently performed by reconstructive and aesthetic surgeons. A main complication of this procedure continues to be the development of capsular contracture (CC), displaying the result of a fibrotic foreign body reaction after the implantation of silicone. For many years, experimental and clinical trials have attempted to analyze the problem of its etiology, treatment, and prophylaxis. Different theories of CC formation are known; however, the reason why different individuals develop CC in days or a month, or only after years, is unknown. Therefore, we hypothesize that CC formation, might primarily be induced by immunological mechanisms along with other reasons. This article attempts to review CC formation, with special attention paid to immunological and inflammatory reasons, as well as actual prophylactic strategies. In this context, the word “biocompatibility” has been frequently used to describe the overall biological innocuousness of silicone in the respective studies, although without clear-cut definitions of this important feature. We have therefore developed a new five-point scale with distinct key points of biocompatibility. Hence, this article might provide the basis for ongoing discussion in this field to reduce single-publication definitions as well as increase the understanding of biocompatibility. Keywords: biofilm, foreign body reaction, breast augmentation, biocompatibility, fibrosis
format	article
author	Steiert AE Boyce M Sorg H
author_facet	Steiert AE Boyce M Sorg H
author_sort	Steiert AE
title	Capsular contracture by silicone breast implants: possible causes, biocompatibility, and prophylactic strategies
title_short	Capsular contracture by silicone breast implants: possible causes, biocompatibility, and prophylactic strategies
title_full	Capsular contracture by silicone breast implants: possible causes, biocompatibility, and prophylactic strategies
title_fullStr	Capsular contracture by silicone breast implants: possible causes, biocompatibility, and prophylactic strategies
title_full_unstemmed	Capsular contracture by silicone breast implants: possible causes, biocompatibility, and prophylactic strategies
title_sort	capsular contracture by silicone breast implants: possible causes, biocompatibility, and prophylactic strategies
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/ff45716b79af49fbb0403989af10c470
work_keys_str_mv	AT steiertae capsularcontracturebysiliconebreastimplantspossiblecausesbiocompatibilityandprophylacticstrategies AT boycem capsularcontracturebysiliconebreastimplantspossiblecausesbiocompatibilityandprophylacticstrategies AT sorgh capsularcontracturebysiliconebreastimplantspossiblecausesbiocompatibilityandprophylacticstrategies
_version_	1718403174087262208

Capsular contracture by silicone breast implants: possible causes, biocompatibility, and prophylactic strategies

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