UCP2 induced by natural birth regulates neuronal differentiation of the hippocampus and related adult behavior.
Mitochondrial uncoupling protein 2 (UCP2) is induced by cellular stress and is involved in regulation of fuel utilization, mitochondrial bioenergetics, cell proliferation, neuroprotection and synaptogenesis in the adult brain. Here we show that natural birth in mice triggers UCP2 expression in hippo...
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Public Library of Science (PLoS)
2012
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oai:doaj.org-article:ff46dbcf26eb496183f1921a9adedcc62021-11-18T07:09:17ZUCP2 induced by natural birth regulates neuronal differentiation of the hippocampus and related adult behavior.1932-620310.1371/journal.pone.0042911https://doaj.org/article/ff46dbcf26eb496183f1921a9adedcc62012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22905184/?tool=EBIhttps://doaj.org/toc/1932-6203Mitochondrial uncoupling protein 2 (UCP2) is induced by cellular stress and is involved in regulation of fuel utilization, mitochondrial bioenergetics, cell proliferation, neuroprotection and synaptogenesis in the adult brain. Here we show that natural birth in mice triggers UCP2 expression in hippocampal neurons. Chemical inhibition or genetic ablation of UCP2 lead to diminished neuronal number and size, dendritic growth and synaptogenezis in vitro and impaired complex behaviors in the adult. These data reveal a critical role for Ucp2 expression in the development of hippocampal neurons and circuits and hippocampus-related adult behaviors.Julia Simon-ArecesMarcelo O DietrichGretchen HermesLuis Miguel Garcia-SeguraMaria-Angeles ArevaloTamas L HorvathPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 8, p e42911 (2012) |
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Medicine R Science Q Julia Simon-Areces Marcelo O Dietrich Gretchen Hermes Luis Miguel Garcia-Segura Maria-Angeles Arevalo Tamas L Horvath UCP2 induced by natural birth regulates neuronal differentiation of the hippocampus and related adult behavior. |
description |
Mitochondrial uncoupling protein 2 (UCP2) is induced by cellular stress and is involved in regulation of fuel utilization, mitochondrial bioenergetics, cell proliferation, neuroprotection and synaptogenesis in the adult brain. Here we show that natural birth in mice triggers UCP2 expression in hippocampal neurons. Chemical inhibition or genetic ablation of UCP2 lead to diminished neuronal number and size, dendritic growth and synaptogenezis in vitro and impaired complex behaviors in the adult. These data reveal a critical role for Ucp2 expression in the development of hippocampal neurons and circuits and hippocampus-related adult behaviors. |
format |
article |
author |
Julia Simon-Areces Marcelo O Dietrich Gretchen Hermes Luis Miguel Garcia-Segura Maria-Angeles Arevalo Tamas L Horvath |
author_facet |
Julia Simon-Areces Marcelo O Dietrich Gretchen Hermes Luis Miguel Garcia-Segura Maria-Angeles Arevalo Tamas L Horvath |
author_sort |
Julia Simon-Areces |
title |
UCP2 induced by natural birth regulates neuronal differentiation of the hippocampus and related adult behavior. |
title_short |
UCP2 induced by natural birth regulates neuronal differentiation of the hippocampus and related adult behavior. |
title_full |
UCP2 induced by natural birth regulates neuronal differentiation of the hippocampus and related adult behavior. |
title_fullStr |
UCP2 induced by natural birth regulates neuronal differentiation of the hippocampus and related adult behavior. |
title_full_unstemmed |
UCP2 induced by natural birth regulates neuronal differentiation of the hippocampus and related adult behavior. |
title_sort |
ucp2 induced by natural birth regulates neuronal differentiation of the hippocampus and related adult behavior. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2012 |
url |
https://doaj.org/article/ff46dbcf26eb496183f1921a9adedcc6 |
work_keys_str_mv |
AT juliasimonareces ucp2inducedbynaturalbirthregulatesneuronaldifferentiationofthehippocampusandrelatedadultbehavior AT marceloodietrich ucp2inducedbynaturalbirthregulatesneuronaldifferentiationofthehippocampusandrelatedadultbehavior AT gretchenhermes ucp2inducedbynaturalbirthregulatesneuronaldifferentiationofthehippocampusandrelatedadultbehavior AT luismiguelgarciasegura ucp2inducedbynaturalbirthregulatesneuronaldifferentiationofthehippocampusandrelatedadultbehavior AT mariaangelesarevalo ucp2inducedbynaturalbirthregulatesneuronaldifferentiationofthehippocampusandrelatedadultbehavior AT tamaslhorvath ucp2inducedbynaturalbirthregulatesneuronaldifferentiationofthehippocampusandrelatedadultbehavior |
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1718423893611380736 |