UCP2 induced by natural birth regulates neuronal differentiation of the hippocampus and related adult behavior.

Mitochondrial uncoupling protein 2 (UCP2) is induced by cellular stress and is involved in regulation of fuel utilization, mitochondrial bioenergetics, cell proliferation, neuroprotection and synaptogenesis in the adult brain. Here we show that natural birth in mice triggers UCP2 expression in hippo...

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Autores principales: Julia Simon-Areces, Marcelo O Dietrich, Gretchen Hermes, Luis Miguel Garcia-Segura, Maria-Angeles Arevalo, Tamas L Horvath
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Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/ff46dbcf26eb496183f1921a9adedcc6
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spelling oai:doaj.org-article:ff46dbcf26eb496183f1921a9adedcc62021-11-18T07:09:17ZUCP2 induced by natural birth regulates neuronal differentiation of the hippocampus and related adult behavior.1932-620310.1371/journal.pone.0042911https://doaj.org/article/ff46dbcf26eb496183f1921a9adedcc62012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22905184/?tool=EBIhttps://doaj.org/toc/1932-6203Mitochondrial uncoupling protein 2 (UCP2) is induced by cellular stress and is involved in regulation of fuel utilization, mitochondrial bioenergetics, cell proliferation, neuroprotection and synaptogenesis in the adult brain. Here we show that natural birth in mice triggers UCP2 expression in hippocampal neurons. Chemical inhibition or genetic ablation of UCP2 lead to diminished neuronal number and size, dendritic growth and synaptogenezis in vitro and impaired complex behaviors in the adult. These data reveal a critical role for Ucp2 expression in the development of hippocampal neurons and circuits and hippocampus-related adult behaviors.Julia Simon-ArecesMarcelo O DietrichGretchen HermesLuis Miguel Garcia-SeguraMaria-Angeles ArevaloTamas L HorvathPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 8, p e42911 (2012)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Julia Simon-Areces
Marcelo O Dietrich
Gretchen Hermes
Luis Miguel Garcia-Segura
Maria-Angeles Arevalo
Tamas L Horvath
UCP2 induced by natural birth regulates neuronal differentiation of the hippocampus and related adult behavior.
description Mitochondrial uncoupling protein 2 (UCP2) is induced by cellular stress and is involved in regulation of fuel utilization, mitochondrial bioenergetics, cell proliferation, neuroprotection and synaptogenesis in the adult brain. Here we show that natural birth in mice triggers UCP2 expression in hippocampal neurons. Chemical inhibition or genetic ablation of UCP2 lead to diminished neuronal number and size, dendritic growth and synaptogenezis in vitro and impaired complex behaviors in the adult. These data reveal a critical role for Ucp2 expression in the development of hippocampal neurons and circuits and hippocampus-related adult behaviors.
format article
author Julia Simon-Areces
Marcelo O Dietrich
Gretchen Hermes
Luis Miguel Garcia-Segura
Maria-Angeles Arevalo
Tamas L Horvath
author_facet Julia Simon-Areces
Marcelo O Dietrich
Gretchen Hermes
Luis Miguel Garcia-Segura
Maria-Angeles Arevalo
Tamas L Horvath
author_sort Julia Simon-Areces
title UCP2 induced by natural birth regulates neuronal differentiation of the hippocampus and related adult behavior.
title_short UCP2 induced by natural birth regulates neuronal differentiation of the hippocampus and related adult behavior.
title_full UCP2 induced by natural birth regulates neuronal differentiation of the hippocampus and related adult behavior.
title_fullStr UCP2 induced by natural birth regulates neuronal differentiation of the hippocampus and related adult behavior.
title_full_unstemmed UCP2 induced by natural birth regulates neuronal differentiation of the hippocampus and related adult behavior.
title_sort ucp2 induced by natural birth regulates neuronal differentiation of the hippocampus and related adult behavior.
publisher Public Library of Science (PLoS)
publishDate 2012
url https://doaj.org/article/ff46dbcf26eb496183f1921a9adedcc6
work_keys_str_mv AT juliasimonareces ucp2inducedbynaturalbirthregulatesneuronaldifferentiationofthehippocampusandrelatedadultbehavior
AT marceloodietrich ucp2inducedbynaturalbirthregulatesneuronaldifferentiationofthehippocampusandrelatedadultbehavior
AT gretchenhermes ucp2inducedbynaturalbirthregulatesneuronaldifferentiationofthehippocampusandrelatedadultbehavior
AT luismiguelgarciasegura ucp2inducedbynaturalbirthregulatesneuronaldifferentiationofthehippocampusandrelatedadultbehavior
AT mariaangelesarevalo ucp2inducedbynaturalbirthregulatesneuronaldifferentiationofthehippocampusandrelatedadultbehavior
AT tamaslhorvath ucp2inducedbynaturalbirthregulatesneuronaldifferentiationofthehippocampusandrelatedadultbehavior
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