Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response

Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response

The Nemo-like kinase (NLK) plays a regulatory role in immune responses. Here, the authors show that NLK inhibits antiviral IFN responses by phosphorylating the mitochondrial antiviral-signaling protein MAVS and describe a MAVS-derived peptide that exhibits antiviral effects both in vitro and in mice...

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Autores principales: Shang-Ze Li, Qi-Peng Shu, Yang Song, Hui-Hui Zhang, Yi Liu, Bing-Xue Jin, Tian-Zi Liuyu, Chao Li, Xi-Chen Huang, Run-Lei Du, Wei Song, Bo Zhong, Xiao-Dong Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/ff479f2686d243949b20b20a1875edd4
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spelling oai:doaj.org-article:ff479f2686d243949b20b20a1875edd42021-12-02T17:33:11ZPhosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response10.1038/s41467-019-11258-x2041-1723https://doaj.org/article/ff479f2686d243949b20b20a1875edd42019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11258-xhttps://doaj.org/toc/2041-1723The Nemo-like kinase (NLK) plays a regulatory role in immune responses. Here, the authors show that NLK inhibits antiviral IFN responses by phosphorylating the mitochondrial antiviral-signaling protein MAVS and describe a MAVS-derived peptide that exhibits antiviral effects both in vitro and in mice.Shang-Ze LiQi-Peng ShuYang SongHui-Hui ZhangYi LiuBing-Xue JinTian-Zi LiuyuChao LiXi-Chen HuangRun-Lei DuWei SongBo ZhongXiao-Dong ZhangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Shang-Ze Li
Qi-Peng Shu
Yang Song
Hui-Hui Zhang
Yi Liu
Bing-Xue Jin
Tian-Zi Liuyu
Chao Li
Xi-Chen Huang
Run-Lei Du
Wei Song
Bo Zhong
Xiao-Dong Zhang
Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response
description The Nemo-like kinase (NLK) plays a regulatory role in immune responses. Here, the authors show that NLK inhibits antiviral IFN responses by phosphorylating the mitochondrial antiviral-signaling protein MAVS and describe a MAVS-derived peptide that exhibits antiviral effects both in vitro and in mice.
format article
author Shang-Ze Li
Qi-Peng Shu
Yang Song
Hui-Hui Zhang
Yi Liu
Bing-Xue Jin
Tian-Zi Liuyu
Chao Li
Xi-Chen Huang
Run-Lei Du
Wei Song
Bo Zhong
Xiao-Dong Zhang
author_facet Shang-Ze Li
Qi-Peng Shu
Yang Song
Hui-Hui Zhang
Yi Liu
Bing-Xue Jin
Tian-Zi Liuyu
Chao Li
Xi-Chen Huang
Run-Lei Du
Wei Song
Bo Zhong
Xiao-Dong Zhang
author_sort Shang-Ze Li
title Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response
title_short Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response
title_full Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response
title_fullStr Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response
title_full_unstemmed Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response
title_sort phosphorylation of mavs/visa by nemo-like kinase (nlk) for degradation regulates the antiviral innate immune response
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/ff479f2686d243949b20b20a1875edd4
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