Dietary mastic oil extracted from Pistacia lentiscus var. chia suppresses tumor growth in experimental colon cancer models

Abstract Plant-derived bioactive compounds attract considerable interest as potential chemopreventive anticancer agents. We analyzed the volatile dietary phytochemicals (terpenes) present in mastic oil extracted from the resin of Pistacia lentiscus var. chia and comparatively investigated their effe...

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Autores principales:	Katerina Spyridopoulou, Angeliki Tiptiri-Kourpeti, Evangeli Lampri, Eleni Fitsiou, Stavros Vasileiadis, Manolis Vamvakias, Haido Bardouki, Anna Goussia, Vasiliki Malamou-Mitsi, Mihalis I. Panayiotidis, Alex Galanis, Aglaia Pappa, Katerina Chlichlia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ff47ae027dd249998d4f8bc1d866e2a3
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spelling	oai:doaj.org-article:ff47ae027dd249998d4f8bc1d866e2a32021-12-02T12:30:18ZDietary mastic oil extracted from Pistacia lentiscus var. chia suppresses tumor growth in experimental colon cancer models10.1038/s41598-017-03971-82045-2322https://doaj.org/article/ff47ae027dd249998d4f8bc1d866e2a32017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03971-8https://doaj.org/toc/2045-2322Abstract Plant-derived bioactive compounds attract considerable interest as potential chemopreventive anticancer agents. We analyzed the volatile dietary phytochemicals (terpenes) present in mastic oil extracted from the resin of Pistacia lentiscus var. chia and comparatively investigated their effects on colon carcinoma proliferation, a) in vitro against colon cancer cell lines and b) in vivo on tumor growth in mice following oral administration. Mastic oil inhibited - more effectively than its major constituents- proliferation of colon cancer cells in vitro, attenuated migration and downregulated transcriptional expression of survivin (BIRC5a). When administered orally, mastic oil inhibited the growth of colon carcinoma tumors in mice. A reduced expression of Ki-67 and survivin in tumor tissues accompanied the observed effects. Notably, only mastic oil -which is comprised of 67.7% α-pinene and 18.8% myrcene- induced a statistically significant anti-tumor effect in mice but not α-pinene, myrcene or a combination thereof. Thus, mastic oil, as a combination of terpenes, exerts growth inhibitory effects against colon carcinoma, suggesting a nutraceutical potential in the fight against colon cancer. To our knowledge, this is the first report showing that orally administered mastic oil induces tumor-suppressing effects against experimental colon cancer.Katerina SpyridopoulouAngeliki Tiptiri-KourpetiEvangeli LampriEleni FitsiouStavros VasileiadisManolis VamvakiasHaido BardoukiAnna GoussiaVasiliki Malamou-MitsiMihalis I. PanayiotidisAlex GalanisAglaia PappaKaterina ChlichliaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Katerina Spyridopoulou Angeliki Tiptiri-Kourpeti Evangeli Lampri Eleni Fitsiou Stavros Vasileiadis Manolis Vamvakias Haido Bardouki Anna Goussia Vasiliki Malamou-Mitsi Mihalis I. Panayiotidis Alex Galanis Aglaia Pappa Katerina Chlichlia Dietary mastic oil extracted from Pistacia lentiscus var. chia suppresses tumor growth in experimental colon cancer models
description	Abstract Plant-derived bioactive compounds attract considerable interest as potential chemopreventive anticancer agents. We analyzed the volatile dietary phytochemicals (terpenes) present in mastic oil extracted from the resin of Pistacia lentiscus var. chia and comparatively investigated their effects on colon carcinoma proliferation, a) in vitro against colon cancer cell lines and b) in vivo on tumor growth in mice following oral administration. Mastic oil inhibited - more effectively than its major constituents- proliferation of colon cancer cells in vitro, attenuated migration and downregulated transcriptional expression of survivin (BIRC5a). When administered orally, mastic oil inhibited the growth of colon carcinoma tumors in mice. A reduced expression of Ki-67 and survivin in tumor tissues accompanied the observed effects. Notably, only mastic oil -which is comprised of 67.7% α-pinene and 18.8% myrcene- induced a statistically significant anti-tumor effect in mice but not α-pinene, myrcene or a combination thereof. Thus, mastic oil, as a combination of terpenes, exerts growth inhibitory effects against colon carcinoma, suggesting a nutraceutical potential in the fight against colon cancer. To our knowledge, this is the first report showing that orally administered mastic oil induces tumor-suppressing effects against experimental colon cancer.
format	article
author	Katerina Spyridopoulou Angeliki Tiptiri-Kourpeti Evangeli Lampri Eleni Fitsiou Stavros Vasileiadis Manolis Vamvakias Haido Bardouki Anna Goussia Vasiliki Malamou-Mitsi Mihalis I. Panayiotidis Alex Galanis Aglaia Pappa Katerina Chlichlia
author_facet	Katerina Spyridopoulou Angeliki Tiptiri-Kourpeti Evangeli Lampri Eleni Fitsiou Stavros Vasileiadis Manolis Vamvakias Haido Bardouki Anna Goussia Vasiliki Malamou-Mitsi Mihalis I. Panayiotidis Alex Galanis Aglaia Pappa Katerina Chlichlia
author_sort	Katerina Spyridopoulou
title	Dietary mastic oil extracted from Pistacia lentiscus var. chia suppresses tumor growth in experimental colon cancer models
title_short	Dietary mastic oil extracted from Pistacia lentiscus var. chia suppresses tumor growth in experimental colon cancer models
title_full	Dietary mastic oil extracted from Pistacia lentiscus var. chia suppresses tumor growth in experimental colon cancer models
title_fullStr	Dietary mastic oil extracted from Pistacia lentiscus var. chia suppresses tumor growth in experimental colon cancer models
title_full_unstemmed	Dietary mastic oil extracted from Pistacia lentiscus var. chia suppresses tumor growth in experimental colon cancer models
title_sort	dietary mastic oil extracted from pistacia lentiscus var. chia suppresses tumor growth in experimental colon cancer models
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ff47ae027dd249998d4f8bc1d866e2a3
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Dietary mastic oil extracted from Pistacia lentiscus var. chia suppresses tumor growth in experimental colon cancer models

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