Effective Doses of Nalbuphine Combined With Propofol for Painless Gastroscopy in Adults: A Randomized Controlled Trial

Objective: This prospective study evaluated the 50% effective dose (ED50) and 95% effective dose (ED95) of nalbuphine combined with propofol during painless gastroscopy.Methods: Seventy-five patients who underwent painless gastroscopy were randomly divided into five groups (group N0, N0.05, N0.1, N0...

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Autores principales:	Shuangfeng Li, Ying Wang, Xiaojian Chen, Tingwan Huang, Na Li
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	nalbuphine propofol gastroscopy dose–effect relationship ED50 ED95 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/ff50c08ffd2f468ea082145024199162
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spelling	oai:doaj.org-article:ff50c08ffd2f468ea0821450241991622021-12-02T00:36:03ZEffective Doses of Nalbuphine Combined With Propofol for Painless Gastroscopy in Adults: A Randomized Controlled Trial1663-981210.3389/fphar.2021.673550https://doaj.org/article/ff50c08ffd2f468ea0821450241991622021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.673550/fullhttps://doaj.org/toc/1663-9812Objective: This prospective study evaluated the 50% effective dose (ED50) and 95% effective dose (ED95) of nalbuphine combined with propofol during painless gastroscopy.Methods: Seventy-five patients who underwent painless gastroscopy were randomly divided into five groups (group N0, N0.05, N0.1, N0.15, and N0.2), with doses of 0, 0.05, 0.1, 0.15, or 0.2 mg/kg nalbuphine in each group. Propofol was given to all groups as the sedative. The bispectral index (BIS) value, propofol dose, examination time, and awakening time were recorded. The number of patients with intolerance indexes (coughing, retching, swallowing, or limb movement) was recorded in each group. The ED50/ED95 of nalbuphine combined with propofol for gastroscopy were calculated.Results: Compared with those of groups N0, N0.05, or N0.1, the propofol dose and awakening time were significantly reduced in group N0.15 or N0.2 (p < 0.05). The successful rate of painless gastroscopy in group N0.15 or N0.2 significantly increased compared to that of group N0 or N0.05 (p < 0.05). When combined with propofol, nalbuphine had an ED50 and ED95 for painless gastroscopy of 0.078 mg/kg (95% CI, 0.056–0.098 mg/kg) and 0.162 mg/kg (95% CI, 0.134–0.217 mg/kg), respectively.Conclusion: The ED50/ED95 of nalbuphine combined with propofol are 0.078 and 0.162 mg/kg, respectively, for painless gastroscopy. Nalbuphine at 0.162 mg/kg combined with propofol is effective and safe for painless gastroscopy in adults.Shuangfeng LiYing WangXiaojian ChenTingwan HuangNa LiFrontiers Media S.A.articlenalbuphinepropofolgastroscopydose–effect relationshipED50ED95Therapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	nalbuphine propofol gastroscopy dose–effect relationship ED50 ED95 Therapeutics. Pharmacology RM1-950
spellingShingle	nalbuphine propofol gastroscopy dose–effect relationship ED50 ED95 Therapeutics. Pharmacology RM1-950 Shuangfeng Li Ying Wang Xiaojian Chen Tingwan Huang Na Li Effective Doses of Nalbuphine Combined With Propofol for Painless Gastroscopy in Adults: A Randomized Controlled Trial
description	Objective: This prospective study evaluated the 50% effective dose (ED50) and 95% effective dose (ED95) of nalbuphine combined with propofol during painless gastroscopy.Methods: Seventy-five patients who underwent painless gastroscopy were randomly divided into five groups (group N0, N0.05, N0.1, N0.15, and N0.2), with doses of 0, 0.05, 0.1, 0.15, or 0.2 mg/kg nalbuphine in each group. Propofol was given to all groups as the sedative. The bispectral index (BIS) value, propofol dose, examination time, and awakening time were recorded. The number of patients with intolerance indexes (coughing, retching, swallowing, or limb movement) was recorded in each group. The ED50/ED95 of nalbuphine combined with propofol for gastroscopy were calculated.Results: Compared with those of groups N0, N0.05, or N0.1, the propofol dose and awakening time were significantly reduced in group N0.15 or N0.2 (p < 0.05). The successful rate of painless gastroscopy in group N0.15 or N0.2 significantly increased compared to that of group N0 or N0.05 (p < 0.05). When combined with propofol, nalbuphine had an ED50 and ED95 for painless gastroscopy of 0.078 mg/kg (95% CI, 0.056–0.098 mg/kg) and 0.162 mg/kg (95% CI, 0.134–0.217 mg/kg), respectively.Conclusion: The ED50/ED95 of nalbuphine combined with propofol are 0.078 and 0.162 mg/kg, respectively, for painless gastroscopy. Nalbuphine at 0.162 mg/kg combined with propofol is effective and safe for painless gastroscopy in adults.
format	article
author	Shuangfeng Li Ying Wang Xiaojian Chen Tingwan Huang Na Li
author_facet	Shuangfeng Li Ying Wang Xiaojian Chen Tingwan Huang Na Li
author_sort	Shuangfeng Li
title	Effective Doses of Nalbuphine Combined With Propofol for Painless Gastroscopy in Adults: A Randomized Controlled Trial
title_short	Effective Doses of Nalbuphine Combined With Propofol for Painless Gastroscopy in Adults: A Randomized Controlled Trial
title_full	Effective Doses of Nalbuphine Combined With Propofol for Painless Gastroscopy in Adults: A Randomized Controlled Trial
title_fullStr	Effective Doses of Nalbuphine Combined With Propofol for Painless Gastroscopy in Adults: A Randomized Controlled Trial
title_full_unstemmed	Effective Doses of Nalbuphine Combined With Propofol for Painless Gastroscopy in Adults: A Randomized Controlled Trial
title_sort	effective doses of nalbuphine combined with propofol for painless gastroscopy in adults: a randomized controlled trial
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/ff50c08ffd2f468ea082145024199162
work_keys_str_mv	AT shuangfengli effectivedosesofnalbuphinecombinedwithpropofolforpainlessgastroscopyinadultsarandomizedcontrolledtrial AT yingwang effectivedosesofnalbuphinecombinedwithpropofolforpainlessgastroscopyinadultsarandomizedcontrolledtrial AT xiaojianchen effectivedosesofnalbuphinecombinedwithpropofolforpainlessgastroscopyinadultsarandomizedcontrolledtrial AT tingwanhuang effectivedosesofnalbuphinecombinedwithpropofolforpainlessgastroscopyinadultsarandomizedcontrolledtrial AT nali effectivedosesofnalbuphinecombinedwithpropofolforpainlessgastroscopyinadultsarandomizedcontrolledtrial
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Effective Doses of Nalbuphine Combined With Propofol for Painless Gastroscopy in Adults: A Randomized Controlled Trial

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