Spermatogenesis associated retrogenes are expressed in the human ovary and ovarian cancers.

<h4>Background</h4>Ovarian cancer is the second most prevalent gynecologic cancer in women. However, it is by far the most lethal. This is generally attributed to the absence of easily detectable markers specific to ovarian cancers that can be used for early diagnosis and specific therap...

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Autores principales:	Jan Rohozinski, Matthew L Anderson, Russell E Broaddus, Creighton L Edwards, Colin E Bishop
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ff51371b9fe64c29983ea1f80755080a
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spelling	oai:doaj.org-article:ff51371b9fe64c29983ea1f80755080a2021-11-25T06:16:25ZSpermatogenesis associated retrogenes are expressed in the human ovary and ovarian cancers.1932-620310.1371/journal.pone.0005064https://doaj.org/article/ff51371b9fe64c29983ea1f80755080a2009-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19333399/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Ovarian cancer is the second most prevalent gynecologic cancer in women. However, it is by far the most lethal. This is generally attributed to the absence of easily detectable markers specific to ovarian cancers that can be used for early diagnosis and specific therapeutic targets.<h4>Methodology/principal findings</h4>Using end point PCR we have found that a family of retrogenes, previously thought to be expressed only in the male testis during spermatogenesis in man, are also expressed in normal ovarian tissue and a large percentage of ovarian cancers. In man there are at least eleven such autosomal retrogenes, which are intronless copies of genes on the X chromosome, essential for normal spermatogenesis and expressed specifically in the human testis. We tested for the expression of five of the known retrogenes, UTP14C, PGK2, RPL10L, RPL39L and UBL4B in normal human ovary and ovarian cancers.<h4>Conclusions/significance</h4>We propose that the activation of the testis specific retrogenes in the ovary and ovarian cancers is of biological significance in humans. Because these retrogenes are specifically expressed in the ovary and ovarian cancers in the female they may prove useful in developing new diagnostic and/or therapeutic targets for ovarian cancer.Jan RohozinskiMatthew L AndersonRussell E BroaddusCreighton L EdwardsColin E BishopPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 3, p e5064 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jan Rohozinski Matthew L Anderson Russell E Broaddus Creighton L Edwards Colin E Bishop Spermatogenesis associated retrogenes are expressed in the human ovary and ovarian cancers.
description	<h4>Background</h4>Ovarian cancer is the second most prevalent gynecologic cancer in women. However, it is by far the most lethal. This is generally attributed to the absence of easily detectable markers specific to ovarian cancers that can be used for early diagnosis and specific therapeutic targets.<h4>Methodology/principal findings</h4>Using end point PCR we have found that a family of retrogenes, previously thought to be expressed only in the male testis during spermatogenesis in man, are also expressed in normal ovarian tissue and a large percentage of ovarian cancers. In man there are at least eleven such autosomal retrogenes, which are intronless copies of genes on the X chromosome, essential for normal spermatogenesis and expressed specifically in the human testis. We tested for the expression of five of the known retrogenes, UTP14C, PGK2, RPL10L, RPL39L and UBL4B in normal human ovary and ovarian cancers.<h4>Conclusions/significance</h4>We propose that the activation of the testis specific retrogenes in the ovary and ovarian cancers is of biological significance in humans. Because these retrogenes are specifically expressed in the ovary and ovarian cancers in the female they may prove useful in developing new diagnostic and/or therapeutic targets for ovarian cancer.
format	article
author	Jan Rohozinski Matthew L Anderson Russell E Broaddus Creighton L Edwards Colin E Bishop
author_facet	Jan Rohozinski Matthew L Anderson Russell E Broaddus Creighton L Edwards Colin E Bishop
author_sort	Jan Rohozinski
title	Spermatogenesis associated retrogenes are expressed in the human ovary and ovarian cancers.
title_short	Spermatogenesis associated retrogenes are expressed in the human ovary and ovarian cancers.
title_full	Spermatogenesis associated retrogenes are expressed in the human ovary and ovarian cancers.
title_fullStr	Spermatogenesis associated retrogenes are expressed in the human ovary and ovarian cancers.
title_full_unstemmed	Spermatogenesis associated retrogenes are expressed in the human ovary and ovarian cancers.
title_sort	spermatogenesis associated retrogenes are expressed in the human ovary and ovarian cancers.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/ff51371b9fe64c29983ea1f80755080a
work_keys_str_mv	AT janrohozinski spermatogenesisassociatedretrogenesareexpressedinthehumanovaryandovariancancers AT matthewlanderson spermatogenesisassociatedretrogenesareexpressedinthehumanovaryandovariancancers AT russellebroaddus spermatogenesisassociatedretrogenesareexpressedinthehumanovaryandovariancancers AT creightonledwards spermatogenesisassociatedretrogenesareexpressedinthehumanovaryandovariancancers AT colinebishop spermatogenesisassociatedretrogenesareexpressedinthehumanovaryandovariancancers
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Spermatogenesis associated retrogenes are expressed in the human ovary and ovarian cancers.

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