AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A

Adaptor protein complex 4 (AP-4) deficiency causes a severe neurological disorder via an unknown mechanism. Here, the authors reveal cargo and machinery of the AP-4 transport pathway, and propose that AP-4 mediates spatial regulation of autophagy through peripheral delivery of ATG9A.

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Autores principales:	Alexandra K. Davies, Daniel N. Itzhak, James R. Edgar, Tara L. Archuleta, Jennifer Hirst, Lauren P. Jackson, Margaret S. Robinson, Georg H. H. Borner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ff52a2aa9d09459f8fa30ecd00dc3289
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spelling	oai:doaj.org-article:ff52a2aa9d09459f8fa30ecd00dc32892021-12-02T14:41:28ZAP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A10.1038/s41467-018-06172-72041-1723https://doaj.org/article/ff52a2aa9d09459f8fa30ecd00dc32892018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06172-7https://doaj.org/toc/2041-1723Adaptor protein complex 4 (AP-4) deficiency causes a severe neurological disorder via an unknown mechanism. Here, the authors reveal cargo and machinery of the AP-4 transport pathway, and propose that AP-4 mediates spatial regulation of autophagy through peripheral delivery of ATG9A.Alexandra K. DaviesDaniel N. ItzhakJames R. EdgarTara L. ArchuletaJennifer HirstLauren P. JacksonMargaret S. RobinsonGeorg H. H. BornerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-21 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alexandra K. Davies Daniel N. Itzhak James R. Edgar Tara L. Archuleta Jennifer Hirst Lauren P. Jackson Margaret S. Robinson Georg H. H. Borner AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A
description	Adaptor protein complex 4 (AP-4) deficiency causes a severe neurological disorder via an unknown mechanism. Here, the authors reveal cargo and machinery of the AP-4 transport pathway, and propose that AP-4 mediates spatial regulation of autophagy through peripheral delivery of ATG9A.
format	article
author	Alexandra K. Davies Daniel N. Itzhak James R. Edgar Tara L. Archuleta Jennifer Hirst Lauren P. Jackson Margaret S. Robinson Georg H. H. Borner
author_facet	Alexandra K. Davies Daniel N. Itzhak James R. Edgar Tara L. Archuleta Jennifer Hirst Lauren P. Jackson Margaret S. Robinson Georg H. H. Borner
author_sort	Alexandra K. Davies
title	AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A
title_short	AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A
title_full	AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A
title_fullStr	AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A
title_full_unstemmed	AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A
title_sort	ap-4 vesicles contribute to spatial control of autophagy via rusc-dependent peripheral delivery of atg9a
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ff52a2aa9d09459f8fa30ecd00dc3289
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AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A

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