Drug-induced hypersensitivity reaction: A case of simultaneous thyroiditis and fulminant type 1 diabetes

A 43-year-old incarcerated man with AIDS was hospitalized for 30 pounds weight loss and diffuse pruritic rash. Three months prior, he was started on dapsone for Pneumocystis jiroveci pneumonia prevention. Biochemical evaluation was remarkable for eosinophilia, thrombocytopenia, acute renal insuffici...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Michael Marchese, Matthew Leinung, Hassan Shawa
Formato:	article
Lenguaje:	EN
Publicado:	Thieme Medical and Scientific Publishers Pvt. Ltd. 2017
Materias:	fulminant type 1 diabetes hypersensitivity syndrome thyroiditis thyrotoxicosis Medicine R
Acceso en línea:	https://doaj.org/article/ff53e5b50cdb4dc383991284ac897edb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ff53e5b50cdb4dc383991284ac897edb
record_format	dspace
spelling	oai:doaj.org-article:ff53e5b50cdb4dc383991284ac897edb2021-12-02T16:37:41ZDrug-induced hypersensitivity reaction: A case of simultaneous thyroiditis and fulminant type 1 diabetes2231-07702249-446410.4103/ajm.AJM_124_16https://doaj.org/article/ff53e5b50cdb4dc383991284ac897edb2017-04-01T00:00:00Zhttp://www.thieme-connect.de/DOI/DOI?10.4103/ajm.AJM_124_16https://doaj.org/toc/2231-0770https://doaj.org/toc/2249-4464A 43-year-old incarcerated man with AIDS was hospitalized for 30 pounds weight loss and diffuse pruritic rash. Three months prior, he was started on dapsone for Pneumocystis jiroveci pneumonia prevention. Biochemical evaluation was remarkable for eosinophilia, thrombocytopenia, acute renal insufficiency, transaminitis, thyrotoxicosis, and significant hyperglycemia (450 mg/dl; nl, 65–99). His hemoglobin A1c level was 5.9% (nl, 4.1–5.6). Thyroid-stimulating immunoglobulin, glutamic acid decarboxylase, and islet cell autoantibodies were within the normal range. He was found to have acute interstitial nephritis based on renal biopsy. He was diagnosed with hypersensitivity reaction due to dapsone. The patient was managed with a tapering dose of corticosteroid, beta-blocker, and multiple daily injections of insulin. The symptoms and biochemical disturbances including thyrotoxicosis resolved within a few weeks. Insulin requirements decreased but diabetes did not resolve with hemoglobin A1c of 6.1% a year after hospitalization. To our knowledge, this is the first case of hypersensitivity reaction due to dapsone causing simultaneous fulminant type 1 diabetes and thyroiditis.Michael MarcheseMatthew LeinungHassan ShawaThieme Medical and Scientific Publishers Pvt. Ltd.articlefulminant type 1 diabeteshypersensitivity syndromethyroiditisthyrotoxicosisMedicineRENAvicenna Journal of Medicine, Vol 07, Iss 02, Pp 67-70 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	fulminant type 1 diabetes hypersensitivity syndrome thyroiditis thyrotoxicosis Medicine R
spellingShingle	fulminant type 1 diabetes hypersensitivity syndrome thyroiditis thyrotoxicosis Medicine R Michael Marchese Matthew Leinung Hassan Shawa Drug-induced hypersensitivity reaction: A case of simultaneous thyroiditis and fulminant type 1 diabetes
description	A 43-year-old incarcerated man with AIDS was hospitalized for 30 pounds weight loss and diffuse pruritic rash. Three months prior, he was started on dapsone for Pneumocystis jiroveci pneumonia prevention. Biochemical evaluation was remarkable for eosinophilia, thrombocytopenia, acute renal insufficiency, transaminitis, thyrotoxicosis, and significant hyperglycemia (450 mg/dl; nl, 65–99). His hemoglobin A1c level was 5.9% (nl, 4.1–5.6). Thyroid-stimulating immunoglobulin, glutamic acid decarboxylase, and islet cell autoantibodies were within the normal range. He was found to have acute interstitial nephritis based on renal biopsy. He was diagnosed with hypersensitivity reaction due to dapsone. The patient was managed with a tapering dose of corticosteroid, beta-blocker, and multiple daily injections of insulin. The symptoms and biochemical disturbances including thyrotoxicosis resolved within a few weeks. Insulin requirements decreased but diabetes did not resolve with hemoglobin A1c of 6.1% a year after hospitalization. To our knowledge, this is the first case of hypersensitivity reaction due to dapsone causing simultaneous fulminant type 1 diabetes and thyroiditis.
format	article
author	Michael Marchese Matthew Leinung Hassan Shawa
author_facet	Michael Marchese Matthew Leinung Hassan Shawa
author_sort	Michael Marchese
title	Drug-induced hypersensitivity reaction: A case of simultaneous thyroiditis and fulminant type 1 diabetes
title_short	Drug-induced hypersensitivity reaction: A case of simultaneous thyroiditis and fulminant type 1 diabetes
title_full	Drug-induced hypersensitivity reaction: A case of simultaneous thyroiditis and fulminant type 1 diabetes
title_fullStr	Drug-induced hypersensitivity reaction: A case of simultaneous thyroiditis and fulminant type 1 diabetes
title_full_unstemmed	Drug-induced hypersensitivity reaction: A case of simultaneous thyroiditis and fulminant type 1 diabetes
title_sort	drug-induced hypersensitivity reaction: a case of simultaneous thyroiditis and fulminant type 1 diabetes
publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
publishDate	2017
url	https://doaj.org/article/ff53e5b50cdb4dc383991284ac897edb
work_keys_str_mv	AT michaelmarchese druginducedhypersensitivityreactionacaseofsimultaneousthyroiditisandfulminanttype1diabetes AT matthewleinung druginducedhypersensitivityreactionacaseofsimultaneousthyroiditisandfulminanttype1diabetes AT hassanshawa druginducedhypersensitivityreactionacaseofsimultaneousthyroiditisandfulminanttype1diabetes
_version_	1718383671862362112

Drug-induced hypersensitivity reaction: A case of simultaneous thyroiditis and fulminant type 1 diabetes

Ejemplares similares