Supramolecular peptide nanostructures: Self-assembly and biomedical applications

To mimic proteins, artificial designed self-assembling peptides (SAPs) that form diverse ordered nanostructures have been developed and served in biomedicine fields. In this review, we focus on four types of readily synthesized SAPs, including short aromatic peptides, peptide amphiphiles, amphipathi...

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Autores principales:	Zhen Du, Baoer Fan, Qiuju Dai, Lan Wang, Jia Guo, Zushan Ye, Naifu Cui, Jie Chen, Kun Tan, Ruixin Li, Wen Tang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Peptides Self-assembly Morphology Anticancer treatment Tumor imaging Antimicrobial Science (General) Q1-390
Acceso en línea:	https://doaj.org/article/ff541feddcc448c0affa81fbecd34bc8
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spelling	oai:doaj.org-article:ff541feddcc448c0affa81fbecd34bc82021-11-10T04:42:00ZSupramolecular peptide nanostructures: Self-assembly and biomedical applications2666-542510.1016/j.giant.2021.100082https://doaj.org/article/ff541feddcc448c0affa81fbecd34bc82022-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2666542521000370https://doaj.org/toc/2666-5425To mimic proteins, artificial designed self-assembling peptides (SAPs) that form diverse ordered nanostructures have been developed and served in biomedicine fields. In this review, we focus on four types of readily synthesized SAPs, including short aromatic peptides, peptide amphiphiles, amphipathic peptides, and surfactant-like peptides. Governed by multiple non-covalent interactions, sequence-coded and condition-altered self-organization of SAPs are presented, leading to the formation of versatile morphologies. The assembly of SAPs is an adaptable platform to incorporate with multiple bioactive motifs by chemical conjugation and physical encapsulation. These multifunctional SAPs-based nano-systems have demonstrated great potential to realize (i) combination therapies for synergetic anticancer effect, (ii) multimodal tumor imaging, (iii) antimicrobial materials that alleviate the drug-resistance problem, (iv) targeting and responsive hemostasis, and (v) active tissue regeneration. Future endeavor is encouraged to focus on the interactions between assemblies and cells, and the development of multi-component assemblies to facilitate the clinical translation of SAPs.Zhen DuBaoer FanQiuju DaiLan WangJia GuoZushan YeNaifu CuiJie ChenKun TanRuixin LiWen TangElsevierarticlePeptidesSelf-assemblyMorphologyAnticancer treatmentTumor imagingAntimicrobialScience (General)Q1-390ENGiant, Vol 9, Iss , Pp 100082- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Peptides Self-assembly Morphology Anticancer treatment Tumor imaging Antimicrobial Science (General) Q1-390
spellingShingle	Peptides Self-assembly Morphology Anticancer treatment Tumor imaging Antimicrobial Science (General) Q1-390 Zhen Du Baoer Fan Qiuju Dai Lan Wang Jia Guo Zushan Ye Naifu Cui Jie Chen Kun Tan Ruixin Li Wen Tang Supramolecular peptide nanostructures: Self-assembly and biomedical applications
description	To mimic proteins, artificial designed self-assembling peptides (SAPs) that form diverse ordered nanostructures have been developed and served in biomedicine fields. In this review, we focus on four types of readily synthesized SAPs, including short aromatic peptides, peptide amphiphiles, amphipathic peptides, and surfactant-like peptides. Governed by multiple non-covalent interactions, sequence-coded and condition-altered self-organization of SAPs are presented, leading to the formation of versatile morphologies. The assembly of SAPs is an adaptable platform to incorporate with multiple bioactive motifs by chemical conjugation and physical encapsulation. These multifunctional SAPs-based nano-systems have demonstrated great potential to realize (i) combination therapies for synergetic anticancer effect, (ii) multimodal tumor imaging, (iii) antimicrobial materials that alleviate the drug-resistance problem, (iv) targeting and responsive hemostasis, and (v) active tissue regeneration. Future endeavor is encouraged to focus on the interactions between assemblies and cells, and the development of multi-component assemblies to facilitate the clinical translation of SAPs.
format	article
author	Zhen Du Baoer Fan Qiuju Dai Lan Wang Jia Guo Zushan Ye Naifu Cui Jie Chen Kun Tan Ruixin Li Wen Tang
author_facet	Zhen Du Baoer Fan Qiuju Dai Lan Wang Jia Guo Zushan Ye Naifu Cui Jie Chen Kun Tan Ruixin Li Wen Tang
author_sort	Zhen Du
title	Supramolecular peptide nanostructures: Self-assembly and biomedical applications
title_short	Supramolecular peptide nanostructures: Self-assembly and biomedical applications
title_full	Supramolecular peptide nanostructures: Self-assembly and biomedical applications
title_fullStr	Supramolecular peptide nanostructures: Self-assembly and biomedical applications
title_full_unstemmed	Supramolecular peptide nanostructures: Self-assembly and biomedical applications
title_sort	supramolecular peptide nanostructures: self-assembly and biomedical applications
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/ff541feddcc448c0affa81fbecd34bc8
work_keys_str_mv	AT zhendu supramolecularpeptidenanostructuresselfassemblyandbiomedicalapplications AT baoerfan supramolecularpeptidenanostructuresselfassemblyandbiomedicalapplications AT qiujudai supramolecularpeptidenanostructuresselfassemblyandbiomedicalapplications AT lanwang supramolecularpeptidenanostructuresselfassemblyandbiomedicalapplications AT jiaguo supramolecularpeptidenanostructuresselfassemblyandbiomedicalapplications AT zushanye supramolecularpeptidenanostructuresselfassemblyandbiomedicalapplications AT naifucui supramolecularpeptidenanostructuresselfassemblyandbiomedicalapplications AT jiechen supramolecularpeptidenanostructuresselfassemblyandbiomedicalapplications AT kuntan supramolecularpeptidenanostructuresselfassemblyandbiomedicalapplications AT ruixinli supramolecularpeptidenanostructuresselfassemblyandbiomedicalapplications AT wentang supramolecularpeptidenanostructuresselfassemblyandbiomedicalapplications
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Supramolecular peptide nanostructures: Self-assembly and biomedical applications

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