Nicotinic acetylcholine receptor agonist attenuates ILC2-dependent airway hyperreactivity

Airway hyperreactivity is driven by type 2 cytokines produced by ILC2 and Th2 cells. Here the authors show that an α7-nicotinic receptor agonist (GTS-21) inhibits ILC2 responses and is therapeutic against Alternaria-induced airway hyperreactivity in a humanized mouse model.

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Autores principales:	Lauriane Galle-Treger, Yuzo Suzuki, Nisheel Patel, Ishwarya Sankaranarayanan, Jennifer L. Aron, Hadi Maazi, Lin Chen, Omid Akbari
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ff5c4e95d75c451a9fe780c3cf581b33
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spelling	oai:doaj.org-article:ff5c4e95d75c451a9fe780c3cf581b332021-12-02T14:39:34ZNicotinic acetylcholine receptor agonist attenuates ILC2-dependent airway hyperreactivity10.1038/ncomms132022041-1723https://doaj.org/article/ff5c4e95d75c451a9fe780c3cf581b332016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13202https://doaj.org/toc/2041-1723Airway hyperreactivity is driven by type 2 cytokines produced by ILC2 and Th2 cells. Here the authors show that an α7-nicotinic receptor agonist (GTS-21) inhibits ILC2 responses and is therapeutic against Alternaria-induced airway hyperreactivity in a humanized mouse model.Lauriane Galle-TregerYuzo SuzukiNisheel PatelIshwarya SankaranarayananJennifer L. AronHadi MaaziLin ChenOmid AkbariNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lauriane Galle-Treger Yuzo Suzuki Nisheel Patel Ishwarya Sankaranarayanan Jennifer L. Aron Hadi Maazi Lin Chen Omid Akbari Nicotinic acetylcholine receptor agonist attenuates ILC2-dependent airway hyperreactivity
description	Airway hyperreactivity is driven by type 2 cytokines produced by ILC2 and Th2 cells. Here the authors show that an α7-nicotinic receptor agonist (GTS-21) inhibits ILC2 responses and is therapeutic against Alternaria-induced airway hyperreactivity in a humanized mouse model.
format	article
author	Lauriane Galle-Treger Yuzo Suzuki Nisheel Patel Ishwarya Sankaranarayanan Jennifer L. Aron Hadi Maazi Lin Chen Omid Akbari
author_facet	Lauriane Galle-Treger Yuzo Suzuki Nisheel Patel Ishwarya Sankaranarayanan Jennifer L. Aron Hadi Maazi Lin Chen Omid Akbari
author_sort	Lauriane Galle-Treger
title	Nicotinic acetylcholine receptor agonist attenuates ILC2-dependent airway hyperreactivity
title_short	Nicotinic acetylcholine receptor agonist attenuates ILC2-dependent airway hyperreactivity
title_full	Nicotinic acetylcholine receptor agonist attenuates ILC2-dependent airway hyperreactivity
title_fullStr	Nicotinic acetylcholine receptor agonist attenuates ILC2-dependent airway hyperreactivity
title_full_unstemmed	Nicotinic acetylcholine receptor agonist attenuates ILC2-dependent airway hyperreactivity
title_sort	nicotinic acetylcholine receptor agonist attenuates ilc2-dependent airway hyperreactivity
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/ff5c4e95d75c451a9fe780c3cf581b33
work_keys_str_mv	AT laurianegalletreger nicotinicacetylcholinereceptoragonistattenuatesilc2dependentairwayhyperreactivity AT yuzosuzuki nicotinicacetylcholinereceptoragonistattenuatesilc2dependentairwayhyperreactivity AT nisheelpatel nicotinicacetylcholinereceptoragonistattenuatesilc2dependentairwayhyperreactivity AT ishwaryasankaranarayanan nicotinicacetylcholinereceptoragonistattenuatesilc2dependentairwayhyperreactivity AT jenniferlaron nicotinicacetylcholinereceptoragonistattenuatesilc2dependentairwayhyperreactivity AT hadimaazi nicotinicacetylcholinereceptoragonistattenuatesilc2dependentairwayhyperreactivity AT linchen nicotinicacetylcholinereceptoragonistattenuatesilc2dependentairwayhyperreactivity AT omidakbari nicotinicacetylcholinereceptoragonistattenuatesilc2dependentairwayhyperreactivity
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Nicotinic acetylcholine receptor agonist attenuates ILC2-dependent airway hyperreactivity

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