Nicotinic acetylcholine receptor agonist attenuates ILC2-dependent airway hyperreactivity

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Nicotinic acetylcholine receptor agonist attenuates ILC2-dependent airway hyperreactivity

Airway hyperreactivity is driven by type 2 cytokines produced by ILC2 and Th2 cells. Here the authors show that an α7-nicotinic receptor agonist (GTS-21) inhibits ILC2 responses and is therapeutic against Alternaria-induced airway hyperreactivity in a humanized mouse model.

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Detalles Bibliográficos
Autores principales:	Lauriane Galle-Treger, Yuzo Suzuki, Nisheel Patel, Ishwarya Sankaranarayanan, Jennifer L. Aron, Hadi Maazi, Lin Chen, Omid Akbari
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ff5c4e95d75c451a9fe780c3cf581b33
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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