Effects of Adiponectin on T2DM and Glucose Homeostasis: A Mendelian Randomization Study

Zefeng Chen,1– 5 Yulan Bai,1– 5 Xinyang Long,1– 5 Qianqian Luo,1– 5 Zheng Wen,1– 5 Yuanfan Li,1– 5 Shengzhu Huang,1– 5 Yunkun Yan,1– 5 Zengnan Mo1– 4,6 1Center for Genomic and Personalized Medicine, Guangxi Med...

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Autores principales:	Chen Z, Bai Y, Long X, Luo Q, Wen Z, Li Y, Huang S, Yan Y, Mo Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	gwass adiponectin mendelian randomization t2dm glucose homeostasis Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/ff5eca742c544c60abc09797752d46d4
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spelling	oai:doaj.org-article:ff5eca742c544c60abc09797752d46d42021-12-02T12:35:11ZEffects of Adiponectin on T2DM and Glucose Homeostasis: A Mendelian Randomization Study1178-7007https://doaj.org/article/ff5eca742c544c60abc09797752d46d42020-05-01T00:00:00Zhttps://www.dovepress.com/effects-of-adiponectin-on-t2dm-and-glucose-homeostasis-a-mendelian-ran-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Zefeng Chen,1– 5 Yulan Bai,1– 5 Xinyang Long,1– 5 Qianqian Luo,1– 5 Zheng Wen,1– 5 Yuanfan Li,1– 5 Shengzhu Huang,1– 5 Yunkun Yan,1– 5 Zengnan Mo1– 4,6 1Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning 530021, Guangxi, People’s Republic of China; 2Guangxi Key Laboratory for Genomic and Personalized Medicine, Nanning 530021, Guangxi, People’s Republic of China; 3Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Nanning 530021, Guangxi, People’s Republic of China; 4Guangxi Key Laboratory of Colleges and Universities, Nanning 530021, Guangxi, People’s Republic of China; 5School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, People’s Republic of China; 6Institute of Urology and Nephrology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, People’s Republic of ChinaCorrespondence: Zengnan MoCenter for Genomic and Personalized Medicine, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, Guangxi, People’s Republic of ChinaTel +86771-5353342Email mozengnan@gxmu.edu.cnPurpose: The associations of adiponectin with type 2 diabetes mellitus (T2DM), glucose homeostasis (including β-cell function index (HOMA-β), insulin resistance (HOMA-IR), fasting insulin (FI) and fasting glucose (FG)) have reported in epidemiological studies. However, the previous observational studies are prone to biases, such as reverse causation and residual confounding factors. Herein, a Mendelian Randomization (MR) study was conducted to determine whether causal effects exist among them.Materials and and Methods: Two-sample MR analyses and multiple sensitivity analyses were performed using the summary data from the ADIPOGen consortium, MAGIC Consortium, and a meta-analysis of GWAS with a considerable sample of T2DM (62,892 cases and 596,424 controls of European ancestry). We got eight valid genetic variants to predict the causal effect among adiponectin and T2DM and glucose homeostasis after excluding the probable invalid or pleiotropic variants.Results: Adiponectin was not associated with T2DM (odds ratio (OR) = 1.004; 95% confidence interval (CI): 0.740, 1.363) when using MR Egger after removing the invalid SNPs, and the results were consistent when using the other four methods. Similar results existed among adiponectin and HOMA-β, HOMA-IR, FI, FG.Conclusion: Our MR study revealed that adiponectin had no causal effect on T2DM and glucose homeostasis and that the associations among them in observational studies may be due to confounding factors.Keywords: GWASs, adiponectin, Mendelian randomization, T2DM, glucose homeostasisChen ZBai YLong XLuo QWen ZLi YHuang SYan YMo ZDove Medical Pressarticlegwassadiponectinmendelian randomizationt2dmglucose homeostasisSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 1771-1784 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	gwass adiponectin mendelian randomization t2dm glucose homeostasis Specialties of internal medicine RC581-951
spellingShingle	gwass adiponectin mendelian randomization t2dm glucose homeostasis Specialties of internal medicine RC581-951 Chen Z Bai Y Long X Luo Q Wen Z Li Y Huang S Yan Y Mo Z Effects of Adiponectin on T2DM and Glucose Homeostasis: A Mendelian Randomization Study
description	Zefeng Chen,1– 5 Yulan Bai,1– 5 Xinyang Long,1– 5 Qianqian Luo,1– 5 Zheng Wen,1– 5 Yuanfan Li,1– 5 Shengzhu Huang,1– 5 Yunkun Yan,1– 5 Zengnan Mo1– 4,6 1Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning 530021, Guangxi, People’s Republic of China; 2Guangxi Key Laboratory for Genomic and Personalized Medicine, Nanning 530021, Guangxi, People’s Republic of China; 3Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Nanning 530021, Guangxi, People’s Republic of China; 4Guangxi Key Laboratory of Colleges and Universities, Nanning 530021, Guangxi, People’s Republic of China; 5School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, People’s Republic of China; 6Institute of Urology and Nephrology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, People’s Republic of ChinaCorrespondence: Zengnan MoCenter for Genomic and Personalized Medicine, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, Guangxi, People’s Republic of ChinaTel +86771-5353342Email mozengnan@gxmu.edu.cnPurpose: The associations of adiponectin with type 2 diabetes mellitus (T2DM), glucose homeostasis (including β-cell function index (HOMA-β), insulin resistance (HOMA-IR), fasting insulin (FI) and fasting glucose (FG)) have reported in epidemiological studies. However, the previous observational studies are prone to biases, such as reverse causation and residual confounding factors. Herein, a Mendelian Randomization (MR) study was conducted to determine whether causal effects exist among them.Materials and and Methods: Two-sample MR analyses and multiple sensitivity analyses were performed using the summary data from the ADIPOGen consortium, MAGIC Consortium, and a meta-analysis of GWAS with a considerable sample of T2DM (62,892 cases and 596,424 controls of European ancestry). We got eight valid genetic variants to predict the causal effect among adiponectin and T2DM and glucose homeostasis after excluding the probable invalid or pleiotropic variants.Results: Adiponectin was not associated with T2DM (odds ratio (OR) = 1.004; 95% confidence interval (CI): 0.740, 1.363) when using MR Egger after removing the invalid SNPs, and the results were consistent when using the other four methods. Similar results existed among adiponectin and HOMA-β, HOMA-IR, FI, FG.Conclusion: Our MR study revealed that adiponectin had no causal effect on T2DM and glucose homeostasis and that the associations among them in observational studies may be due to confounding factors.Keywords: GWASs, adiponectin, Mendelian randomization, T2DM, glucose homeostasis
format	article
author	Chen Z Bai Y Long X Luo Q Wen Z Li Y Huang S Yan Y Mo Z
author_facet	Chen Z Bai Y Long X Luo Q Wen Z Li Y Huang S Yan Y Mo Z
author_sort	Chen Z
title	Effects of Adiponectin on T2DM and Glucose Homeostasis: A Mendelian Randomization Study
title_short	Effects of Adiponectin on T2DM and Glucose Homeostasis: A Mendelian Randomization Study
title_full	Effects of Adiponectin on T2DM and Glucose Homeostasis: A Mendelian Randomization Study
title_fullStr	Effects of Adiponectin on T2DM and Glucose Homeostasis: A Mendelian Randomization Study
title_full_unstemmed	Effects of Adiponectin on T2DM and Glucose Homeostasis: A Mendelian Randomization Study
title_sort	effects of adiponectin on t2dm and glucose homeostasis: a mendelian randomization study
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/ff5eca742c544c60abc09797752d46d4
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Effects of Adiponectin on T2DM and Glucose Homeostasis: A Mendelian Randomization Study

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