Post-acute COVID-19 syndrome after reinfection and vaccine breakthrough by the SARS-CoV-2 Gamma variant in Brazil

Post-acute COVID-19 syndrome after reinfection and vaccine breakthrough by the SARS-CoV-2 Gamma variant in Brazil

We describe a case of prolonged COVID-19 caused by the SARS-CoV-2 Gamma variant in a fully vaccinated healthcare worker, 387 days after an infection caused by lineage B.1.1.33. Infections were confirmed by whole-genome sequencing and corroborated by the detection of neutralizing antibodies in conval...

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Autores principales: Stephanie L.S. Penetra, Michele F.B. da Silva, Paola Resende, Anielle Pina-Costa, Heloisa F.P. Santos, Lusiele Guaraldo, Guilherme A. Calvet, Maria Ogrzewalska, Ighor Arantes, Ketiuce Zukeram, Mia F. de Araújo, Ana Beatriz Machado Lima, Renata Serrano Lopes, Larissa R. Lira-Silva, Isabella V. Moraes, Mayumi D. Wakimoto, Trevon L. Fuller, Claudia Raja Gabaglia, Otávio M. Espíndola, Myrna C. Bonaldo, Cláudio Tadeu Daniel-Ribeiro, Jimmy Whitworth, Chris Smith, Karin Nielsen-Saines, Alex Pauvolid-Correa, Marilda M. Siqueira, Patricia Brasil
Formato: article
Lenguaje:EN
Publicado: Elsevier 2022
Materias:
SARS-CoV-2 variants
whole-genome sequencing
reinfection
post-acute COVID-19 syndrome
COVID-19 breakthrough infection
health personnel
Infectious and parasitic diseases
RC109-216
Acceso en línea:https://doaj.org/article/ff5fa8534a6e4f7fbf344394547fa7a5
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Sumario:We describe a case of prolonged COVID-19 caused by the SARS-CoV-2 Gamma variant in a fully vaccinated healthcare worker, 387 days after an infection caused by lineage B.1.1.33. Infections were confirmed by whole-genome sequencing and corroborated by the detection of neutralizing antibodies in convalescent serum samples. Considering the permanent exposure of this healthcare worker to SARS-CoV-2, the waning immunity after the first infection, the low efficacy of the inactivated vaccine at preventing COVID-19, the immune escape of the Gamma variant (VOC), and the burden of post-COVID syndrome, this individual would have benefited from an additional dose of a heterologous vaccine.

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