Aerobic training increases skin perfusion by a nitric oxide mechanism in type 2 diabetes

Sheri R Colberg1, Laura C Hill2, Henri K Parson3, Kathleen S Thomas1, Aaron I Vinik31Old Dominion University, Norfolk; 2State University of New York at Cortland, New York; 3Eastern Virginia Medical School, Norfolk, VirginiaAbstract: It is well known that a number of locally released vasodilatory and...

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Autor principal:	Colberg SR
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	skin perfusion aerobic training type 2 diabetes nitric oxide prostaglandins endothelial-derived hyperpolarizing factor microdialysis Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/ff609b81603f4635b6383af1b0c9332b
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spelling	oai:doaj.org-article:ff609b81603f4635b6383af1b0c9332b2021-12-02T01:46:03ZAerobic training increases skin perfusion by a nitric oxide mechanism in type 2 diabetes1178-7007https://doaj.org/article/ff609b81603f4635b6383af1b0c9332b2010-08-01T00:00:00Zhttps://www.dovepress.com/aerobic-training-increases-skin-perfusion-by-a-nitric-oxide-mechanism--peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Sheri R Colberg1, Laura C Hill2, Henri K Parson3, Kathleen S Thomas1, Aaron I Vinik31Old Dominion University, Norfolk; 2State University of New York at Cortland, New York; 3Eastern Virginia Medical School, Norfolk, VirginiaAbstract: It is well known that a number of locally released vasodilatory and vasoconstrictive compounds can affect skin perfusion. This study investigated the effects of aerobic training on the contribution of nitric oxide (NO), prostaglandins (PG), and endothelial-derived hyperpolarizing factor (EDHF) in stimulated dorsal foot skin perfusion in individuals with type 2 diabetes (T2DM). Ten previously sedentary, older individuals with T2DM (57.0 ± 3.1 years) and nine sedentary controls (53.5 ± 3.2 years) were tested before and after undertaking six months of moderate aerobic training three times weekly in a supervised setting. All subjects underwent measurement of baseline (32°C) and heat-stimulated (40°C and 44°C) dorsal foot skin perfusion starting one hour after ingestion of a single, oral 325 mg dose of aspirin, a known inhibitor of PG synthesis. Before aspirin ingestion, a subcutaneous microdialysis probe was inserted into each foot dorsum to administer either saline (PG pathway only blocked by aspirin in the left foot) or L-NAME (N(G)-nitro-l-arginine methyl ester; thereby inhibiting both PG and NO pathways in the right foot). Normative data collected previously on subjects undergoing saline administration via microdialysis without aspirin ingestion served as a control group. Significantly lower responsiveness of maximal perfusion was found with the EDHF pathway alone unblocked compared with NO and EDHF unblocked after training. Maximal suppression attributable directly to NO, PG, and EDHF was not significantly different when examined by subject group and training status. However, contributions of NO, PG, and EDHF to maximal perfusion were significantly increased, decreased, and unchanged by aerobic training, respectively, with diabetic and control subjects combined due to nonsignificant differences between groups. Improvements in maximally stimulated dorsal foot skin perfusion resulting from six months of aerobic training appear to have primarily an NO basis, with lesser contributions from PG following training, regardless of diabetes status.Keywords: skin perfusion, aerobic training, type 2 diabetes, nitric oxide, prostaglandins, endothelial-derived hyperpolarizing factor, microdialysisColberg SRDove Medical Pressarticleskin perfusionaerobic trainingtype 2 diabetesnitric oxideprostaglandinsendothelial-derived hyperpolarizing factormicrodialysisSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 3, Pp 275-280 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	skin perfusion aerobic training type 2 diabetes nitric oxide prostaglandins endothelial-derived hyperpolarizing factor microdialysis Specialties of internal medicine RC581-951
spellingShingle	skin perfusion aerobic training type 2 diabetes nitric oxide prostaglandins endothelial-derived hyperpolarizing factor microdialysis Specialties of internal medicine RC581-951 Colberg SR Aerobic training increases skin perfusion by a nitric oxide mechanism in type 2 diabetes
description	Sheri R Colberg1, Laura C Hill2, Henri K Parson3, Kathleen S Thomas1, Aaron I Vinik31Old Dominion University, Norfolk; 2State University of New York at Cortland, New York; 3Eastern Virginia Medical School, Norfolk, VirginiaAbstract: It is well known that a number of locally released vasodilatory and vasoconstrictive compounds can affect skin perfusion. This study investigated the effects of aerobic training on the contribution of nitric oxide (NO), prostaglandins (PG), and endothelial-derived hyperpolarizing factor (EDHF) in stimulated dorsal foot skin perfusion in individuals with type 2 diabetes (T2DM). Ten previously sedentary, older individuals with T2DM (57.0 ± 3.1 years) and nine sedentary controls (53.5 ± 3.2 years) were tested before and after undertaking six months of moderate aerobic training three times weekly in a supervised setting. All subjects underwent measurement of baseline (32°C) and heat-stimulated (40°C and 44°C) dorsal foot skin perfusion starting one hour after ingestion of a single, oral 325 mg dose of aspirin, a known inhibitor of PG synthesis. Before aspirin ingestion, a subcutaneous microdialysis probe was inserted into each foot dorsum to administer either saline (PG pathway only blocked by aspirin in the left foot) or L-NAME (N(G)-nitro-l-arginine methyl ester; thereby inhibiting both PG and NO pathways in the right foot). Normative data collected previously on subjects undergoing saline administration via microdialysis without aspirin ingestion served as a control group. Significantly lower responsiveness of maximal perfusion was found with the EDHF pathway alone unblocked compared with NO and EDHF unblocked after training. Maximal suppression attributable directly to NO, PG, and EDHF was not significantly different when examined by subject group and training status. However, contributions of NO, PG, and EDHF to maximal perfusion were significantly increased, decreased, and unchanged by aerobic training, respectively, with diabetic and control subjects combined due to nonsignificant differences between groups. Improvements in maximally stimulated dorsal foot skin perfusion resulting from six months of aerobic training appear to have primarily an NO basis, with lesser contributions from PG following training, regardless of diabetes status.Keywords: skin perfusion, aerobic training, type 2 diabetes, nitric oxide, prostaglandins, endothelial-derived hyperpolarizing factor, microdialysis
format	article
author	Colberg SR
author_facet	Colberg SR
author_sort	Colberg SR
title	Aerobic training increases skin perfusion by a nitric oxide mechanism in type 2 diabetes
title_short	Aerobic training increases skin perfusion by a nitric oxide mechanism in type 2 diabetes
title_full	Aerobic training increases skin perfusion by a nitric oxide mechanism in type 2 diabetes
title_fullStr	Aerobic training increases skin perfusion by a nitric oxide mechanism in type 2 diabetes
title_full_unstemmed	Aerobic training increases skin perfusion by a nitric oxide mechanism in type 2 diabetes
title_sort	aerobic training increases skin perfusion by a nitric oxide mechanism in type 2 diabetes
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/ff609b81603f4635b6383af1b0c9332b
work_keys_str_mv	AT colbergsr aerobictrainingincreasesskinperfusionbyanitricoxidemechanismintype2diabetes
_version_	1718402936509300736

Aerobic training increases skin perfusion by a nitric oxide mechanism in type 2 diabetes

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